Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

(2017) Srinath Kasturirangan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact

(2016) Guiliana Soraya Victoria et al.   Scientific Reports

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models

(2014) D. Games et al.   JOURNAL OF NEUROSCIENCE

ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo

(2014) Brian Spencer et al.   MOLECULAR THERAPY

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

(2014) Veronica Lindström et al.   NEUROBIOLOGY OF DISEASE

Why are Astrocytes Important?

(2014) Alexei Verkhratsky et al.   NEUROCHEMICAL RESEARCH

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Impact of Immune Complex Size and Glycosylation on IgG Binding to Human Fc Rs

(2013) A. Lux et al.   JOURNAL OF IMMUNOLOGY

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

(2013) Won-Suk Chung et al.   NATURE

α-Synuclein and Mitochondria: Partners in Crime?

(2013) Ken Nakamura   Neurotherapeutics

Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death

(2013) A Faroni et al.   Cell Death & Disease

Neurological Diseases as Primary Gliopathies: A Reassessment of Neurocentrism

(2012) Alexei Verkhratsky et al.   ASN Neuro

Astrocytic regulation of glutamate homeostasis in epilepsy

(2012) Douglas A. Coulter et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE

(2012) Raasay S. Jones et al.   Journal of Neuroimmune Pharmacology

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury

(2012) Camilla Lööv et al.   PLoS One

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells

(2011) Thomas Näsström et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor

(2010) Jennifer D. Sokolowski et al.   BRAIN BEHAVIOR AND IMMUNITY

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

(2010) Thomas Näsström et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Potency and Fate Specification in CNS Stem Cell Populations In Vitro

(2008) Rea Ravin et al.   Cell Stem Cell