Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 14, Pages 5117
Publisher
MDPI AG
Online
2020-07-20
DOI
10.3390/ijms21145117
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Carotid body chemosensitivity: early biomarker of dysmetabolism in humans
- (2020) João P Cunha-Guimaraes et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- P2X3 receptor antagonism reduces the occurrence of apnoeas in newborn rats
- (2020) Pedro Lourenço Katayama et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Obesity: global epidemiology and pathogenesis
- (2019) Matthias Blüher Nature Reviews Endocrinology
- Carotid body enlargement in hypertension and other comorbidities evaluated by ultrasonography
- (2019) Jie Tan et al. JOURNAL OF HYPERTENSION
- Leptin Induces Hypertension Acting on Transient Receptor Potential Melastatin 7 Channel in the Carotid Body
- (2019) Mi-Kyung Shin et al. CIRCULATION RESEARCH
- Physiology of the Carotid Body: From Molecules to Disease
- (2019) Patricia Ortega-Sáenz et al. Annual Review of Physiology
- Decoding Neural Metabolic Markers From the Carotid Sinus Nerve in a Type 2 Diabetes Model
- (2019) Marina Cracchiolo et al. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
- Effects of intravenous low-dose dopamine infusion on glucose regulation during prolonged aerobic exercise
- (2018) Blair D. Johnson et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Purinergic plasticity within petrosal neurons in hypertension
- (2018) Davi J.A. Moraes et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia
- (2018) Nanduri R. Prabhakar et al. CELL AND TISSUE RESEARCH
- The Global Epidemic of the Metabolic Syndrome
- (2018) Mohammad G. Saklayen CURRENT HYPERTENSION REPORTS
- Role of the carotid body chemoreceptors in glucose homeostasis and thermoregulation in humans
- (2018) Michael J. Joyner et al. JOURNAL OF PHYSIOLOGY-LONDON
- High fat diet blunts the effects of leptin on ventilation and on carotid body activity
- (2018) Maria J. Ribeiro et al. JOURNAL OF PHYSIOLOGY-LONDON
- The role of hypoxia-inducible factors in carotid body (patho) physiology
- (2018) Gregg L. Semenza et al. JOURNAL OF PHYSIOLOGY-LONDON
- The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes
- (2018) Sofie Hædersdal et al. MAYO CLINIC PROCEEDINGS
- Carotid body: a metabolic sensor implicated in insulin resistance
- (2018) Silvia V. Conde et al. PHYSIOLOGICAL GENOMICS
- Glucose, insulin, and the carotid body chemoreceptors in humans
- (2018) Jacqueline K. Limberg PHYSIOLOGICAL GENOMICS
- Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity
- (2018) Thomaz Fleury Curado et al. SLEEP
- Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response Through Altering TASK Channel Expression
- (2018) Fang Yuan et al. Frontiers in Physiology
- Sleep-disordered breathing in C57BL/6J mice with diet-induced obesity
- (2018) Thomaz Fleury Curado et al. SLEEP
- Intranasal Leptin Relieves Sleep Disordered Breathing in Mice with Diet Induced Obesity
- (2018) Slava Berger et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Leptin acts in the carotid bodies to increase minute ventilation during wakefulness and sleep and augment the hypoxic ventilatory response
- (2018) Candela Caballero-Eraso et al. JOURNAL OF PHYSIOLOGY-LONDON
- Effect of adrenal medullectomy on metabolic responses to chronic intermittent hypoxia in the frequently sampled intravenous glucose tolerance test
- (2017) Mi-Kyung Shin et al. JOURNAL OF APPLIED PHYSIOLOGY
- Insulin action and resistance in obesity and type 2 diabetes
- (2017) Michael P Czech NATURE MEDICINE
- Complementary roles of gasotransmitters CO and H2S in sleep apnea
- (2017) Ying-Jie Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE)
- (2017) Abir Bhattacharjee et al. ACS Medicinal Chemistry Letters
- Metabolic Syndrome Prevalence by Race/Ethnicity and Sex in the United States, National Health and Nutrition Examination Survey, 1988–2012
- (2017) Justin Xavier Moore et al. Preventing Chronic Disease
- Inflammation mediates the association between visceral adiposity and obstructive sleep apnea in adolescents
- (2016) Jordan Gaines et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver
- (2016) Joana F. Sacramento et al. DIABETOLOGIA
- Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea
- (2016) Nanduri R. Prabhakar EXPERIMENTAL PHYSIOLOGY
- Carotid Body Ablation Abrogates Hypertension and Autonomic Alterations Induced by Intermittent Hypoxia in RatsNovelty and Significance
- (2016) Rodrigo Del Rio et al. HYPERTENSION
- The effect of leptin replacement on sleep-disordered breathing in the leptin-deficient ob/ob mouse
- (2016) H. Pho et al. JOURNAL OF APPLIED PHYSIOLOGY
- Insulin resistance: a new consequence of altered carotid body chemoreflex?
- (2016) Silvia V. Conde et al. JOURNAL OF PHYSIOLOGY-LONDON
- Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2sensitivity during hypoglycaemia: a role for the carotid body
- (2016) Emma L. Thompson et al. JOURNAL OF PHYSIOLOGY-LONDON
- Single cell transcriptome analysis of mouse carotid body glomus cells
- (2016) Ting Zhou et al. JOURNAL OF PHYSIOLOGY-LONDON
- Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical translation
- (2016) José López-Barneo et al. MOLECULAR ASPECTS OF MEDICINE
- Purinergic receptors in the carotid body as a new drug target for controlling hypertension
- (2016) Wioletta Pijacka et al. NATURE MEDICINE
- H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
- (2016) Guoxiang Yuan et al. Science Signaling
- Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep
- (2016) Qiaoling Yao et al. SLEEP
- H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea
- (2016) Guoxiang Yuan et al. Science Signaling
- Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep
- (2016) Qiaoling Yao et al. SLEEP
- Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling
- (2015) M. Carmen Fernández-Agüera et al. Cell Metabolism
- Effect of Bilateral Carotid Body Resection on Cardiac Baroreflex Control of Blood Pressure During HypoglycemiaNovelty and Significance
- (2015) Jacqueline K. Limberg et al. HYPERTENSION
- Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea
- (2015) Gregg L. Semenza et al. JOURNAL OF APPLIED PHYSIOLOGY
- Effects of carotid body tumor resection on the blood pressure of essential hypertensive patients
- (2015) Marat Fudim et al. Journal of the American Society of Hypertension
- P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
- (2015) Rayid Abdulqawi et al. LANCET
- Oxygen regulation of breathing through an olfactory receptor activated by lactate
- (2015) Andy J. Chang et al. NATURE
- Regulation of carotid body oxygen sensing by hypoxia-inducible factors
- (2015) Nanduri R. Prabhakar et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Tasting arterial blood: what do the carotid chemoreceptors sense?
- (2015) Nanduri R. Prabhakhar et al. Frontiers in Physiology
- Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice
- (2014) M. Bassi et al. Acta Physiologica
- Intermittent hypoxia-induced glucose intolerance is abolished by α-adrenergic blockade or adrenal medullectomy
- (2014) Jonathan C. Jun et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- An O2-Sensitive Glomus Cell-Stem Cell Synapse Induces Carotid Body Growth in Chronic Hypoxia
- (2014) Aida Platero-Luengo et al. CELL
- Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans
- (2014) Jacqueline K. Limberg et al. EXPERIMENTAL PHYSIOLOGY
- Effect of bilateral carotid body resection on the counterregulatory response to hypoglycaemia in humans
- (2014) Erica A. Wehrwein et al. EXPERIMENTAL PHYSIOLOGY
- Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia
- (2014) Mi-Kyung Shin et al. JOURNAL OF APPLIED PHYSIOLOGY
- Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation
- (2014) Andrew P. Holmes et al. JOURNAL OF PHYSIOLOGY-LONDON
- Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors
- (2014) Colin A. Nurse JOURNAL OF PHYSIOLOGY-LONDON
- Regulation of hypoxia-inducible factor-α isoforms and redox state by carotid body neural activity in rats
- (2014) Ying-Jie Peng et al. JOURNAL OF PHYSIOLOGY-LONDON
- Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema
- (2014) Y.-J. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Carotid body, insulin, and metabolic diseases: unraveling the links
- (2014) SÃlvia V. Conde et al. Frontiers in Physiology
- Glucose sensing by carotid body glomus cells: potential implications in disease
- (2014) Lin Gao et al. Frontiers in Physiology
- Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
- (2013) Luciano F. Drager et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications
- (2013) Theodore Kelesidis ANNALS OF INTERNAL MEDICINE
- Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
- (2013) Julian F. R. Paton et al. CURRENT HYPERTENSION REPORTS
- Carotid Body Denervation Prevents the Development of Insulin Resistance and Hypertension Induced by Hypercaloric Diets
- (2013) Maria J. Ribeiro et al. DIABETES
- Role of the Carotid Body in Obesity-Related Sympathoactivation
- (2013) Andrea Porzionato et al. HYPERTENSION
- Metabolic Consequences of Sleep-Disordered Breathing
- (2013) J. Jun et al. ILAR JOURNAL
- Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues
- (2013) Qiaoling Yao et al. JOURNAL OF LIPID RESEARCH
- Electrophysiological Properties of Rostral Ventrolateral Medulla Presympathetic Neurons Modulated by the Respiratory Network in Rats
- (2013) D. J. A. Moraes et al. JOURNAL OF NEUROSCIENCE
- Sensing hypoxia: physiology, genetics and epigenetics
- (2013) Nanduri R. Prabhakar JOURNAL OF PHYSIOLOGY-LONDON
- Obstructive Sleep Apnea
- (2013) Luciano F. Drager et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Prevalence and Trends of Metabolic Syndrome in the Adult U.S. Population, 1999–2010
- (2013) Hiram Beltrán-Sánchez et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mutual antagonism between hypoxia-inducible factors 1 and 2 regulates oxygen sensing and cardio-respiratory homeostasis
- (2013) G. Yuan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Obstructive Sleep Apnea is Associated with Increased Chemoreflex Sensitivity in Patients with Metabolic Syndrome
- (2013) Ivani C. Trombetta et al. SLEEP
- The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension
- (2013) Fiona D. McBryde et al. Nature Communications
- Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice
- (2012) Jonathan C. Jun et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Cardiorespiratory variability following repeat acute hypoxia in the conscious SHR versus two normotensive rat strains
- (2012) L.F. Hayward et al. AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
- Intermittent hypoxia and systemic leptin administration induces pSTAT3 and Fos/Fra-1 in the carotid body
- (2012) Scott A. Messenger et al. BRAIN RESEARCH
- Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7
- (2012) V Chubanov et al. BRITISH JOURNAL OF PHARMACOLOGY
- Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels
- (2012) Xin Qin et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases
- (2012) Julian F.R. Paton et al. HYPERTENSION
- Sympatho-adrenal activation by chronic intermittent hypoxia
- (2012) Nanduri R. Prabhakar et al. JOURNAL OF APPLIED PHYSIOLOGY
- Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat
- (2012) J. Ciriello et al. NEUROSCIENCE
- Effects of intermittent hypoxia on leptin signalling in the carotid body
- (2012) S.A. Messenger et al. NEUROSCIENCE
- Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
- (2012) Nanduri R. Prabhakar et al. PHYSIOLOGICAL REVIEWS
- Signal processing at mammalian carotid body chemoreceptors
- (2012) Colin A. Nurse et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Effects of low glucose on carotid body chemoreceptor cell activity studied in cultures of intact organs and in dissociated cells
- (2011) Teresa Gallego-Martin et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats
- (2011) João H. Costa-Silva et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Expression of leptin and leptin receptor isoforms in the rat and human carotid body
- (2011) Andrea Porzionato et al. BRAIN RESEARCH
- Angiotensin and carotid body chemoreception in heart failure
- (2011) Harold D Schultz CURRENT OPINION IN PHARMACOLOGY
- Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea
- (2011) L. F. Drager et al. EUROPEAN HEART JOURNAL
- Leptin receptor signaling: pathways to leptin resistance
- (2011) Joris Wauman Frontiers in Bioscience-Landmark
- Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension
- (2011) Maciej Siński et al. HYPERTENSION RESEARCH
- Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse
- (2011) A. B. Hernandez et al. JOURNAL OF APPLIED PHYSIOLOGY
- Lack of Association Between Impaired Glucose Tolerance and Appetite Regulating Hormones in Patients with Obstructive Sleep Apnea
- (2011) Ioannis Papaioannou et al. Journal of Clinical Sleep Medicine
- Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia
- (2011) Ana Q. Silva et al. JOURNAL OF PHYSIOLOGY-LONDON
- Intermittent Hypoxia Exacerbates Metabolic Effects of Diet-Induced Obesity
- (2011) Luciano F. Drager et al. Obesity
- Hypoxia-inducible factor 2 (HIF-2 ) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
- (2011) Y.-J. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Obesity Hypoventilation Syndrome
- (2010) Amanda J. Piper et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia
- (2010) David G. Gerst et al. JOURNAL OF APPLIED PHYSIOLOGY
- Carotid body function and ventilatory responses in intermittent hypoxia. evidence for anomalous brainstem integration of arterial chemoreceptor input
- (2010) M.C. Gonzalez-Martín et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Carotid body chemosensory responses in mice deficient of TASK channels
- (2010) Patricia Ortega-Sáenz et al. JOURNAL OF GENERAL PHYSIOLOGY
- Hyperoxia blunts counterregulation during hypoglycaemia in humans: possible role for the carotid bodies?
- (2010) Erica A. Wehrwein et al. JOURNAL OF PHYSIOLOGY-LONDON
- Role of blood flow in carotid body chemoreflex function in heart failure
- (2010) Y. Ding et al. JOURNAL OF PHYSIOLOGY-LONDON
- Sympathetic nervous activation in obesity and the metabolic syndrome—Causes, consequences and therapeutic implications
- (2010) Gavin W. Lambert et al. PHARMACOLOGY & THERAPEUTICS
- Pathophysiology of Sleep Apnea
- (2010) Jerome A. Dempsey et al. PHYSIOLOGICAL REVIEWS
- H2S mediates O2 sensing in the carotid body
- (2010) Y.-J. Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leptin at 14 y of age: an ongoing story
- (2009) Jeffrey M Friedman AMERICAN JOURNAL OF CLINICAL NUTRITION
- Recent advances in understanding leptin signaling and leptin resistance
- (2009) David L. Morris et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
- (2009) Jonathan Jun et al. ATHEROSCLEROSIS
- Breathing at high altitude
- (2009) Vincent Joseph et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR
- (2009) Zhi-Yong Tan et al. CIRCULATION RESEARCH
- NADPH Oxidase Is Required for the Sensory Plasticity of the Carotid Body by Chronic Intermittent Hypoxia
- (2009) Y.- J. Peng et al. JOURNAL OF NEUROSCIENCE
- Intermittent hypoxia degrades HIF-2 via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities
- (2009) J. Nanduri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sympathetic response to chemostimulation in conscious rats exposed to chronic intermittent hypoxia
- (2009) Jianhua Huang et al. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
- Leptin resistance: a prediposing factor for diet-induced obesity
- (2008) Philip J. Scarpace et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
- (2008) Vladimir Savransky et al. CIRCULATION RESEARCH
- Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier
- (2008) Akihiko Urayama et al. ENDOCRINOLOGY
- Induction of HIF-1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+signaling, prolyl hydroxylases, and mTOR
- (2008) Guoxiang Yuan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A Role for TASK-1 (KCNK3) Channels in the Chemosensory Control of Breathing
- (2008) S. Trapp et al. JOURNAL OF NEUROSCIENCE
- Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity
- (2008) Daniel B. Zoccal et al. JOURNAL OF PHYSIOLOGY-LONDON
- Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension?
- (2008) Annabel E. Simms et al. JOURNAL OF PHYSIOLOGY-LONDON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation