Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels

Natural and synthetic modulators of SK (Kca2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7

(2012) V Chubanov et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPM7 Is Required for Breast Tumor Cell Metastasis

(2012) Jeroen Middelbeek et al.   CANCER RESEARCH

Molecular Targets of FTY720 (Fingolimod)

(2012) M.R. Pitman et al.   CURRENT MOLECULAR MEDICINE

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels

(2011) Susanna Zierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPM7 Is Required within Zebrafish Sensory Neurons for the Activation of Touch-Evoked Escape Behaviors

(2011) S. E. Low et al.   JOURNAL OF NEUROSCIENCE

The channel kinase, TRPM7, is required for early embryonic development

(2011) J. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity

(2011) Jia Xie et al.   Scientific Reports

The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations

(2011) Xuanmao Chen et al.   Molecular Brain

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes

(2010) Jaya Sahni et al.   CELL CYCLE

TRPM7-Mediated Ca 2+ Signals Confer Fibrogenesis in Human Atrial Fibrillation

(2010) Jianyang Du et al.   CIRCULATION RESEARCH

TRPM6 and TRPM7: A Mul-TRP-PLIK-Cation of Channel Functions

(2010) Loren W. Runnels   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

TRPM7 regulates gastrulation during vertebrate embryogenesis

(2010) Wei Liu et al.   DEVELOPMENTAL BIOLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of TRPM7 Channel Activity and Cell Death by Inhibitors of 5-Lipoxygenase

(2010) Hsiang-Chin Chen et al.   PLoS One

TRPM7 is essential for Mg2+ homeostasis in mammals

(2010) Lillia V. Ryazanova et al.   Nature Communications

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

(2009) Moshe Parnas et al.   CELL CALCIUM

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity

(2009) Jianyang Du et al.   JOURNAL OF GENERAL PHYSIOLOGY

Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia

(2009) Hong-Shuo Sun et al.   NATURE NEUROSCIENCE

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells

(2008) Yasuo Nagaoka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress

(2008) Trung H.M. Pham et al.   IMMUNITY

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis

(2008) J. Jin et al.   SCIENCE