Purinergic receptors in the carotid body as a new drug target for controlling hypertension

P2X3 receptors and sensitization of autonomic reflexes

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Sensory input to the central nervous system from the lungs and airways: A prominent role for purinergic signalling via P2X2/3 receptors

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Mechanisms of carotid body chemoreflex dysfunction during heart failure

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P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

(2015) Rayid Abdulqawi et al.   LANCET

Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension (the ROX CONTROL HTN study): a randomised controlled trial

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Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators

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TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing

(2015) Keith J. Buckler   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Protein kinase G–regulated production of H2S governs oxygen sensing

(2015) Guoxiang Yuan et al.   Science Signaling

Protein kinase G–regulated production of H2S governs oxygen sensing

(2015) Guoxiang Yuan et al.   Science Signaling

P2X3 Receptors Mediate Visceral Hypersensitivity during Acute Chemically-Induced Colitis and in the Post-Inflammatory Phase via Different Mechanisms of Sensitization

(2015) Annemie Deiteren et al.   PLoS One

Executive Summary: Heart Disease and Stroke Statistics—2014 Update

(2014) Alan S. Go et al.   CIRCULATION

The human carotid body releases acetylcholine, ATP and cytokines during hypoxia

(2014) Jessica Kåhlin et al.   EXPERIMENTAL PHYSIOLOGY

Specific Respiratory Neuron Types Have Increased Excitability That Drive Presympathetic Neurones in Neurogenic Hypertension

(2014) Davi J. A. Moraes et al.   HYPERTENSION

Arteriovenous Anastomosis

(2014) Amy E. Burchell et al.   HYPERTENSION

Synaptic and paracrine mechanisms at carotid body arterial chemoreceptors

(2014) Colin A. Nurse   JOURNAL OF PHYSIOLOGY-LONDON

Resistant Hypertension

(2013) Robert M. Carey   HYPERTENSION

Electrophysiological Properties of Rostral Ventrolateral Medulla Presympathetic Neurons Modulated by the Respiratory Network in Rats

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Age-related changes in afferent pathways and urothelial function in the male mouse bladder

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Purinergic signalling in the gastrointestinal tract and related organs in health and disease

(2013) Geoffrey Burnstock   Purinergic Signalling

Petrosal ganglion responses to acetylcholine and ATP are enhanced by chronic normobaric hypoxia in the rabbit

(2013) Gabriel Icekson et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension

(2013) Fiona D. McBryde et al.   Nature Communications

Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice

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The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases

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Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat

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Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension

(2011) Maciej Siński et al.   HYPERTENSION RESEARCH

Carotid chemoreceptor modulation of blood flow during exercise in healthy humans

(2011) Michael K. Stickland et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deep brain stimulation relieves refractory hypertension

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AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

(2010) Joel R Gever et al.   BRITISH JOURNAL OF PHARMACOLOGY

Carotid Baroreceptor Stimulation, Sympathetic Activity, Baroreflex Function, and Blood Pressure in Hypertensive Patients

(2010) Karsten Heusser et al.   HYPERTENSION

Accelerating the pulse of cardiovascular R&D

(2010) Andrew Plump   NATURE REVIEWS DRUG DISCOVERY

Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR

(2009) Zhi-Yong Tan et al.   CIRCULATION RESEARCH

Interleukin-6 increases intracellular Ca2+concentration and induces catecholamine secretion in rat carotid body glomus cells

(2009) Juan Fan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study

(2009) Henry Krum et al.   LANCET

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

Aliskiren

(2008) Morris J. Brown   CIRCULATION

Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity

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