Mast Cell Tryptase Promotes Inflammatory Bowel Disease–Induced Intestinal Fibrosis

Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis

(2019) Chiko Shimbori et al.   THORAX

Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148

(2018) Konstantin Tsoyi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The controversial role of mast cells in fibrosis

(2018) Peter Bradding et al.   IMMUNOLOGICAL REVIEWS

BCL2 Regulates Differentiation of Intestinal Fibroblasts

(2018) Bruce Weder et al.   INFLAMMATORY BOWEL DISEASES

Inhibition of Fibroblast Activation Protein Restores a Balanced Extracellular Matrix and Reduces Fibrosis in Crohn’s Disease Strictures Ex Vivo

(2018) Marta Truffi et al.   INFLAMMATORY BOWEL DISEASES

Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

(2018) Liwen Wei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2

(2018) Mariam Bagher et al.   Cell Communication and Signaling

Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis

(2018) A. Hünerwadel et al.   Scientific Reports

Tryptase Promotes the Profibrotic Phenotype Transfer of Atrial Fibroblasts by PAR2 and PPARγ Pathway

(2018) Hongwei Tan et al.   ARCHIVES OF MEDICAL RESEARCH

Degranulation of gastrointestinal mast cells contributes to hepatic ischemia–reperfusion injury in mice

(2018) Zhigang He et al.   CLINICAL SCIENCE

Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

(2018) Do-Kyun Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons

(2018) Zhigang He et al.   Cell Death & Disease

Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor

(2017) Tom Holvoet et al.   GASTROENTEROLOGY

Bile duct ligation-induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell-deficient KitW-sh mice

(2017) Laura Hargrove et al.   HEPATOLOGY

Early Phase Mast Cell Activation Determines the Chronic Outcome of Renal Ischemia–Reperfusion Injury

(2017) Luca Danelli et al.   JOURNAL OF IMMUNOLOGY

ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice

(2017) Quan Sun et al.   Scientific Reports

Fibroblasts and myofibroblasts of the intestinal lamina propria in physiology and disease

(2016) Manolis Roulis et al.   DIFFERENTIATION

P4H9-detected molecule expression on spindle-shaped fibroblasts indicates malignant phenotype of colorectal cancer

(2015) Shozo Yokoyama et al.   BRITISH JOURNAL OF CANCER

NADPH Oxidase 4 Induces Cardiac Fibrosis and Hypertrophy Through Activating Akt/mTOR and NF B Signaling Pathways

(2015) Q. D. Zhao et al.   CIRCULATION

ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model

(2014) Yifeng Wang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cells

(2014) Jing Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mast Cells and Fibroblasts Work in Concert to Aggravate Pulmonary Fibrosis

(2013) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

(2012) Florian Rieder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal myofibroblasts: targets for stem cell therapy

(2011) R. C. Mifflin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mesenchymal Cells of the Intestinal Lamina Propria

(2011) D.W. Powell et al.   Annual Review of Physiology

Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain

(2011) E. J. Meuillet   CURRENT MEDICINAL CHEMISTRY

Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top-Down” approach to intestinal fibrosis in mice

(2011) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

Substance P Modulates Colitis-Asscociated Fibrosis

(2010) Hon Wai Koon et al.   AMERICAN JOURNAL OF PATHOLOGY

S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration

(2010) Michael F. Cunningham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Risk Factors Associated With Progression to Intestinal Complications of Crohn's Disease in a Population-Based Cohort

(2010) Kelvin T. Thia et al.   GASTROENTEROLOGY

Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/−) mice

(2010) Sunila Mahavadi et al.   INFLAMMATORY BOWEL DISEASES

Targeting TGF-β1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis

(2009) Yanbing Ma et al.   INFLAMMATORY BOWEL DISEASES

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment

(2008) Hiroyuki Koga et al.   SURGERY

Recent trends in the surgical management of inflammatory bowel disease

(2008) Robert E Roses et al.   WORLD JOURNAL OF GASTROENTEROLOGY