MHC class I transactivator NLRC5 in host immunity, cancer and beyond

Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity

(2020) Lauren K. Zebertavage et al.   Scientific Reports

NLRC5 deficiency has a moderate impact on immunodominant CD 8 + T‐cell responses during rotavirus infection of adult mice

(2019) Tian Sun et al.   IMMUNOLOGY AND CELL BIOLOGY

Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance

(2019) Saptha Vijayan et al.   IMMUNOGENETICS

NLRC5 negatively regulates LTA‐induced inflammation via TLR2/NF‐κB and participates in TLR2‐mediated allergic airway inflammation

(2019) Muzi Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer

(2018) Calogerina Catalano et al.   PLoS One

Regulatory NLRs Control the RLR-Mediated Type I Interferon and Inflammatory Responses in Human Dendritic Cells

(2018) Tünde Fekete et al.   Frontiers in Immunology

High Expression of NLRC5 is associated with prognosis of gastric cancer

(2018) Yuemei Li et al.   Open Medicine

NLRC5 mediates cell proliferation, migration, and invasion by regulating the Wnt/β-catenin signalling pathway in clear cell renal cell carcinoma

(2018) Qin Wang et al.   CANCER LETTERS

Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 + T Cell Function and Impaired Viral Clearance

(2017) Christopher R. Lupfer et al.   JOURNAL OF VIROLOGY

NLRC5 silencing ameliorates cardiac fibrosis by inhibiting the TGF-β1/Smad3 signaling pathway

(2017) Hongtao Zhou et al.   Molecular Medicine Reports

CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression

(2016) Isaac Downs et al.   BIOFACTORS

NLRC5 regulates cell proliferation, migration and invasion in hepatocellular carcinoma by targeting the Wnt/β-catenin signaling pathway

(2016) Yun-yun Peng et al.   CANCER LETTERS

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

NLRC5 regulates TGF-β1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis

(2016) Tao Xu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

(2016) Sayuri Yoshihama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma

(2016) Ying-hua He et al.   TOXICOLOGY

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8+ T lymphocytes

(2016) Galaxia M. Rodriguez et al.   OncoImmunology

NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients

(2015) XIAOYU LI et al.   Oncology Letters

NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

(2015) Kristina Ludigs et al.   PLoS Genetics

Unusual Structural Features Revealed by the Solution NMR Structure of the NLRC5 Caspase Recruitment Domain

(2014) Petrus G. M. Gutte et al.   BIOCHEMISTRY

NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection

(2014) Priya Ranjan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NLRC5 Mediates Cytokine Secretion in RAW264.7 Macrophages and Modulated by the JAK2/STAT3 Pathway

(2014) Lin Li et al.   INFLAMMATION

The N-Terminal Domain of NLRC5 Confers Transcriptional Activity for MHC Class I and II Gene Expression

(2014) Andreas Neerincx et al.   JOURNAL OF IMMUNOLOGY

Gliomas and the vascular fragility of the blood brain barrier

(2014) Luiz Gustavo Dubois et al.   Frontiers in Cellular Neuroscience

A molecular model of the full-length human NOD-like receptor family CARD domain containing 5 (NLRC5) protein

(2013) János Mótyán et al.   BMC BIOINFORMATICS

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

MHC Class I Antigen Processing and Presenting Machinery: Organization, Function, and Defects in Tumor Cells

(2013) P. Leone et al.   JNCI-Journal of the National Cancer Institute

The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity

(2012) Torsten B. Meissner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

(2012) Yikun Yao et al.   CELL RESEARCH

Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice

(2012) Yanzheng Tong et al.   CELL RESEARCH

Regulation of Class I Major Histocompatibility Complex (MHC) by Nucleotide-binding Domain, Leucine-rich Repeat-containing (NLR) Proteins

(2012) Gregory R. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Controls Basal MHC Class I Gene Expression in an MHC Enhanceosome-Dependent Manner

(2012) A. Neerincx et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells

(2012) F. Staehli et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Impaired MHC Class I Expression in Mice Deficient for Nlrc5/Class I Transactivator

(2012) A. Biswas et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Cooperates with the RFX Transcription Factor Complex To Induce MHC Class I Gene Expression

(2012) T. B. Meissner et al.   JOURNAL OF IMMUNOLOGY

Novel insights into the molecular mechanisms of HLA class I abnormalities

(2011) Barbara Seliger   CANCER IMMUNOLOGY IMMUNOTHERAPY

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: Implications for immunotherapy

(2010) Federico Garrido et al.   INTERNATIONAL JOURNAL OF CANCER

A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses

(2010) Andreas Neerincx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

The Nucleotide-Binding Oligomerization Domain-Like Receptor NLRC5 Is Involved in IFN-Dependent Antiviral Immune Responses

(2010) Sven Kuenzel et al.   JOURNAL OF IMMUNOLOGY

NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections

(2010) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE