Priming of microglia with IFN ‐γ impairs adult hippocampal neurogenesis and leads to depression‐like behaviors and cognitive defects

Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice

(2020) Lifen Liu et al.   BRAIN RESEARCH BULLETIN

The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2‐deficient leukoencephalopathy

(2020) Noémie Hamilton et al.   GLIA

Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice

(2020) Peili Hu et al.   NEUROPHARMACOLOGY

Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ

(2019) Thuy-Truc Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emotion Regulation of Hippocampus Using Real-Time fMRI Neurofeedback in Healthy Human

(2019) Yashuo Zhu et al.   Frontiers in Human Neuroscience

Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability

(2019) Yue Zhang et al.   BIOLOGICAL PSYCHIATRY

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

(2019) Vandana Deora et al.   GLIA

Microglial cell‐derived interleukin‐6 influences behavior and inflammatory response in the brain following traumatic brain injury

(2019) Paula Sanchis et al.   GLIA

The role of the cerebellum for feedback processing and behavioral switching in a reversal-learning task

(2018) Jutta Peterburs et al.   BRAIN AND COGNITION

Running exercise protects against myelin breakdown in the absence of neurogenesis in the hippocampus of AD mice

(2018) Feng-lei Chao et al.   BRAIN RESEARCH

The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis

(2018) A. M. Overstreet et al.   Mucosal Immunology

Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

(2018) Pedro Baptista et al.   Frontiers in Neuroanatomy

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus

(2018) Christoph Anacker et al.   NATURE

Microglial activation occurs late during preclinical Alzheimer's disease

(2018) Wolfgang J. Streit et al.   GLIA

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

IFN-γ Producing Th1 Cells Induce Different Transcriptional Profiles in Microglia and Astrocytes

(2018) Chittappen K. Prajeeth et al.   Frontiers in Cellular Neuroscience

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

(2018) Lijuan Zhang et al.   Frontiers in Cellular Neuroscience

Pre-aging of the Olfactory Bulb in Major Depression With High Comorbidity of Mental Disorders

(2018) Fabian Rottstaedt et al.   Frontiers in Aging Neuroscience

IFN-γ promotes transendothelial migration of CD4+ T cells across the blood-brain barrier

(2017) Sandip Ashok Sonar et al.   IMMUNOLOGY AND CELL BIOLOGY

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer’s Disease

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia-dependent synapse loss in type I interferon-mediated lupus

(2017) Allison R. Bialas et al.   NATURE

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

The role of the immunoproteasome in interferon-γ-mediated microglial activation

(2017) Kasey E. Moritz et al.   Scientific Reports

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

(2016) Jin-qiang Zhang et al.   ACTA PHARMACOLOGICA SINICA

Microglial dysfunction connects depression and Alzheimer’s disease

(2016) Luís Eduardo Santos et al.   BRAIN BEHAVIOR AND IMMUNITY

P2Y12receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases

(2016) Alexander Mildner et al.   GLIA

Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1

(2016) Jianguo Xu et al.   GLIA

Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production

(2016) Nicholas G. Spencer et al.   PLoS One

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

(2016) S Monteiro et al.   Translational Psychiatry

Roles of microglia in brain development, tissue maintenance and repair

(2015) Mackenzie A. Michell-Robinson et al.   BRAIN

Dissociable contributions of amygdala and hippocampus to emotion and memory in patients with Alzheimer's disease

(2015) Edmarie Guzmán-Vélez et al.   HIPPOCAMPUS

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

(2015) Ismini E. Papageorgiou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Minocycline treatment ameliorates interferon-alpha- induced neurogenic defects and depression-like behaviors in mice

(2015) Lian-Shun Zheng et al.   Frontiers in Cellular Neuroscience

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

(2015) J Guadagno et al.   Cell Death & Disease

The subpopulation of microglia sensitive to neurotransmitters/neurohormones is modulated by stimulation with LPS, interferon-γ, and IL-4

(2014) Maria Pannell et al.   GLIA

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

(2013) Antoine Lampron et al.   NEURON

Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases

(2013) L. Steinman   Science Signaling

Immune-neural connections: how the immune system's response to infectious agents influences behavior

(2012) R. H. McCusker et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS

(2012) Carsten Minten et al.   PLoS One

Depression and Hippocampal Neurogenesis: A Road to Remission?

(2012) A. J. Eisch et al.   SCIENCE

CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis

(2011) Emanuele Tirotta et al.   GLIA

The Multifaceted Profile of Activated Microglia

(2009) Marina A. Lynch   MOLECULAR NEUROBIOLOGY

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Orchestrating brain-cell renewal: the role of immune cells in adult neurogenesis in health and disease

(2008) Yaniv Ziv et al.   TRENDS IN MOLECULAR MEDICINE

Immune-based regulation of adult neurogenesis: Implications for learning and memory

(2007) Yaniv Ziv et al.   BRAIN BEHAVIOR AND IMMUNITY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE