B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury

A phosphokinome-based screen uncovers new drug synergies for cancer driven by liver-specific gain of nononcogenic receptor tyrosine kinases

(2017) Yannan Fan et al.   HEPATOLOGY

Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development

(2016) Jessica Endig et al.   CANCER CELL

Hepatocellular Carcinoma Regression After Cessation of Immunosuppressive Therapy

(2016) Abhijeet Kumar et al.   JOURNAL OF CLINICAL ONCOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

Immunological landscape and immunotherapy of hepatocellular carcinoma

(2015) Jesús Prieto et al.   Nature Reviews Gastroenterology & Hepatology

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Clinical Aspects of Tumor Necrosis Factor-α Signaling in Hepatocellular Carcinoma

(2014) Myoung-Kuk Jang et al.   CURRENT PHARMACEUTICAL DESIGN

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Characterization of animal models for primary sclerosing cholangitis (PSC)

(2014) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury

(2013) Silke Marhenke et al.   GUT

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Incidence and long-term risk of de novo malignancies after liver transplantation with implications for prevention and detection

(2013) Harald Schrem et al.   LIVER TRANSPLANTATION

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Inflammation- and stress-related signaling pathways in hepatocarcinogenesis

(2012) Hayato Nakagawa   WORLD JOURNAL OF GASTROENTEROLOGY

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia

(2008) Hila Barash et al.   HEPATOLOGY