Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis

Chlorpyrifos Suppresses Neutrophil Extracellular Traps in Carp by Promoting Necroptosis and Inhibiting Respiratory Burst Caused by the PKC/MAPK Pathway

(2019) Qiaojian Zhang et al.   Oxidative Medicine and Cellular Longevity

Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis

(2019) Cristina Florean et al.   FREE RADICAL BIOLOGY AND MEDICINE

Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway

(2019) Huiying Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

(2019) Yuping Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPK/NF-κB Pathway in Broiler Spleen

(2019) Qianru Chi et al.   Oxidative Medicine and Cellular Longevity

Neurotoxicity induced by microcystins and cylindrospermopsin: A review

(2019) M.G. Hinojosa et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Zinc oxide nanoparticles induce necroptosis and inhibit autophagy in MCF-7 human breast cancer cells

(2019) Maryam Farasat et al.   BIOLOGIA

Immunoengineering in glioblastoma imaging and therapy

(2019) Steven Zanganeh et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats

(2019) Reihaneh Ebrahimi et al.   DARU-Journal of Pharmaceutical Sciences

Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway

(2018) Liping Zhang et al.   Cardiovascular Toxicology

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis Contributes to Urban Particulate Matter-Induced Airway Epithelial Injury

(2018) Feng Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine

(2018) Hainan Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Necrosis in human neuronal cells exposed to paraquat

(2018) Naho Hirayama et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

(2018) Xianbo Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Characterizing of fine particulate matter (PM1) on the platforms and outdoor areas of underground and surface subway stations

(2017) Ferdos Kord Mostafapour et al.   HUMAN AND ECOLOGICAL RISK ASSESSMENT

Vaccinia virus evasion of regulated cell death

(2017) David L. Veyer et al.   IMMUNOLOGY LETTERS

NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation

(2017) Xiao-Ming Meng et al.   LABORATORY INVESTIGATION

Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation

(2017) Nima Sanadgol et al.   METABOLIC BRAIN DISEASE

Exploitation of necroptosis for treatment of caspase-compromised cancers

(2017) Young Sik Cho et al.   Oncology Letters

Biogenic selenium nanoparticles induce ROS-mediated necroptosis in PC-3 cancer cells through TNF activation

(2017) Praveen Sonkusre et al.   JOURNAL OF NANOBIOTECHNOLOGY

Regulation of necroptosis signaling and cell death by reactive oxygen species

(2016) Simone Fulda   BIOLOGICAL CHEMISTRY

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells

(2016) Lianshuang Zhang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Synthesis and evaluation of alendronate-modified gelatin biopolymer as a novel osteotropic nanocarrier for gene therapy

(2016) George M Mekhail et al.   Nanomedicine

Nano-ZnO leads to tubulin macrotube assembly and actin bundling, triggering cytoskeletal catastrophe and cell necrosis

(2016) Lorena García-Hevia et al.   Nanoscale

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

(2016) Anurag R. Mishra et al.   TOXICOLOGICAL SCIENCES

Organelles and chromatin fragmentation of human umbilical vein endothelial cell influence by the effects of zeta potential and size of silver nanoparticles in different manners

(2016) Shima Tavakol et al.   Artificial Cells Nanomedicine and Biotechnology

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

The role of necroptosis in neurosurgical diseases

(2015) T. Liu et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Cationic nanocarriers induce cell necrosis through impairment of Na+/K+-ATPase and cause subsequent inflammatory response

(2015) Xiawei Wei et al.   CELL RESEARCH

Necrotic cell death induced by the protein-mediated intercellular uptake of CdTe quantum dots

(2015) Lu Lai et al.   CHEMOSPHERE

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury

(2015) H. Fan et al.   NEUROSCIENCE

The molecular relationships between apoptosis, autophagy and necroptosis

(2015) Najoua Lalaoui et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Necroptosis: The Trojan horse in cell autonomous antiviral host defense

(2015) Edward S. Mocarski et al.   VIROLOGY

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

(2015) S Saveljeva et al.   Cell Death & Disease

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage

(2014) S Hassani et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Toxicity of ZnO Nanoparticles to Macrophages Due to Cell Uptake and Intracellular Release of Zinc Ions

(2014) Bing Wang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Staying Alive: Cell Death in Antiviral Immunity

(2014) Jason W. Upton et al.   MOLECULAR CELL

Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury

(2014) Y. Wang et al.   NEUROSCIENCE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct activation of RIP3/MLKL-dependent necrosis by herpes simplex virus 1 (HSV-1) protein ICP6 triggers host antiviral defense

(2014) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice

(2014) Ye-Fa Zhang et al.   TOXICOLOGY LETTERS

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation

(2013) Ryodai Shindo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluation of reactive Epstein–Barr Virus (EBV) in Iranian patient with different subtypes of multiple sclerosis (MS)

(2013) Nourollah Ramroodi et al.   Brazilian Journal of Infectious Diseases

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes

(2013) F Basit et al.   CELL DEATH AND DIFFERENTIATION

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

(2013) Y Murakami et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gold nanoparticles trigger apoptosis and necrosis in lung cancer cells with low intracellular glutathione

(2013) Min Liu et al.   JOURNAL OF NANOPARTICLE RESEARCH

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

(2013) David M. Moquin et al.   PLoS One

Silver nanoparticles: cytotoxic, apoptotic, and necrotic effects on MCF-7 cells

(2013) Hakan ÇİFTÇİ et al.   TURKISH JOURNAL OF BIOLOGY

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy

(2012) Yuan-Chao Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

(2012) Yao-Qi Wang et al.   NEUROCHEMICAL RESEARCH

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells

(2011) Alexander T. Bauer et al.   BIOMATERIALS

Controllable synthesis of monodispersed silver nanoparticles as standards for quantitative assessment of their cytotoxicity

(2011) Lun Li et al.   BIOMATERIALS

24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

(2011) Kazunori Yamanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shape-Dependent Cytotoxicity of Polyaniline Nanomaterials in Human Fibroblast Cells

(2011) Wan-Kyu Oh et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Surface charge of gold nanoparticles mediates mechanism of toxicity

(2011) Nicole M. Schaeublin et al.   Nanoscale

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

(2011) J. V. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway

(2011) Yu-Hsin Ma et al.   TOXICOLOGY LETTERS

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

(2011) S Zhu et al.   Cell Death & Disease

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium

(2010) Gerhard Krumschnabel et al.   AQUATIC TOXICOLOGY

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

Multiple roles of cadmium in cell death and survival

(2010) Douglas M. Templeton et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Anti-proliferative activity of silver nanoparticles

(2009) PV AshaRani et al.   BMC CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

(2009) Benjamin Yazdanpanah et al.   NATURE

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆

(2009) M.F. Rahman et al.   TOXICOLOGY LETTERS

Crystal structure mediates mode of cell death in TiO2 nanotoxicity

(2008) Laura K. Braydich-Stolle et al.   JOURNAL OF NANOPARTICLE RESEARCH

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

(2008) C. Carlson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

IAP-targeted therapies for cancer

(2008) E C LaCasse et al.   ONCOGENE