Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence

Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2014, an Activator of Silent Information Regulator 2 Ortholog 1

(2020) Nobuaki Miyaji et al.   Cartilage

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cellular Senescence: The Trojan Horse in Chronic Lung Diseases

(2019) Shruthi Hamsanathan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Catalpol Alleviates Adriamycin‐Induced Nephropathy by Activating the SIRT1 Signalling Pathway In Vivo and In Vitro

(2019) Jiangnan Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition

(2019) Zhen-Hua Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice

(2019) Chun-Mei Duan et al.   BEHAVIOURAL BRAIN RESEARCH

Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema

(2018) Isaac K Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

SRT2104 attenuates diabetes-induced aortic endothelial dysfunction via inhibition of P53

(2018) Hao Wu et al.   JOURNAL OF ENDOCRINOLOGY

MicroRNA-570 is a novel regulator of cellular senescence and inflammaging

(2018) Jonathan R. Baker et al.   FASEB JOURNAL

Acute Lung Injury in Response to Intratracheal Instillation of Lipopolysaccharide in an Animal Model of Emphysema Induced by Elastase

(2017) Maria Aparecida Esteves Rabelo et al.   INFLAMMATION

LncRNA-mediated SIRT1/FoxO3a and SIRT1/p53 signaling pathways regulate type II alveolar epithelial cell senescence in patients with chronic obstructive pulmonary disease

(2017) Chao Gu et al.   Molecular Medicine Reports

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

(2015) V. Conti et al.   Analytical Cellular Pathology

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

(2015) James G. Krueger et al.   PLoS One

Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells

(2014) Amit R. Agarwal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema

(2014) Chao Gu et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Differentiation of human amniotic fluid-derived mesenchymal stem cells into type II alveolar epithelial cells in vitro

(2014) YAQING LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Structure and Evolution of Human Sirtuins

(2013) Domenico Bordo   CURRENT DRUG TARGETS

Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway

(2013) Fernanda Augusta de Lima Barbosa Guterres et al.   EXPERIMENTAL CELL RESEARCH

Alveolar epithelial cells: Master regulators of lung homeostasis

(2013) Loïc Guillot et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alveolar Epithelial Stem and Progenitor Cells: Emerging Evidence for their Role in Lung Regeneration

(2012) A. M. Hoffman et al.   CURRENT MEDICINAL CHEMISTRY

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A

(2012) Shyamala Ganesan et al.   THORAX

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Isolation of alveolar epithelial type II progenitor cells from adult human lungs

(2010) Naoya Fujino et al.   LABORATORY INVESTIGATION

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke

(2009) Hongao Zheng et al.   TOXICOLOGY LETTERS