Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease

Age-related changes in tissue macrophages precede cardiac functional impairment

(2016) Alexander R. Pinto et al.   Aging-US

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

(2015) Zhu Xu et al.   CELL CYCLE

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

(2015) Coen H. Wiegman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MARK-AGE biomarkers of ageing

(2015) Alexander Bürkle et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Effect of Spirulina Intervention on Oxidative Stress, Antioxidant Status, and Lipid Profile in Chronic Obstructive Pulmonary Disease Patients

(2015) Md. Ismail et al.   Biomed Research International

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

(2014) Christina M. Warboys et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression

(2014) Paula Frizera Vassallo et al.   BLOOD

SnapShot: Mammalian Sirtuins

(2014) Kristin A. Anderson et al.   CELL

Signaling pathway cross talk in Alzheimer’s disease

(2014) Juan A Godoy et al.   Cell Communication and Signaling

Benefits of High-Dose N-Acetylcysteine to Exacerbation-Prone Patients With COPD

(2014) Hoi Nam Tse et al.   CHEST

Regulation of Akt Signaling by Sirtuins

(2014) Vinodkumar B. Pillai et al.   CIRCULATION RESEARCH

Telomerase mutations in smokers with severe emphysema

(2014) Susan E. Stanley et al.   JOURNAL OF CLINICAL INVESTIGATION

Feasibility of 8-OHdG formation and hOGG1 induction in PBMCs for assessing oxidative DNA damage in the lung of COPD patients

(2014) Shifang Yang et al.   RESPIROLOGY

COPD: maximization of bronchodilation

(2014) Stefano Nardini et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Application of Proteomics and Peptidomics to COPD

(2014) Girolamo Pelaia et al.   Biomed Research International

Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

(2014) Rong Liu et al.   Biomed Research International

Cytokine inhibition in the treatment of COPD

(2014) Kian Fan Chung et al.   International Journal of Chronic Obstructive Pulmonary Disease

Current overview of functions of FoxO proteins, with special regards to cellular homeostasis, cell response to stress, as well as inflammation and aging

(2013) M Wątroba et al.   Advances in Medical Sciences

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

Can We Delay the Accelerated Lung Aging in COPD? Anti-Aging Molecules and Interventions

(2013) Andriana I. Papaioannou et al.   CURRENT DRUG TARGETS

Histone deacetylases and their inhibitors

(2013) Simon G. Royce et al.   Current Opinion in Allergy and Clinical Immunology

Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins

(2013) Graziamaria Corbi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress and antioxidant enzyme activity in South Indian male smokers with Chronic Obstructive Pulmonary Disease

(2013) Arja Cholendra et al.   RESPIROLOGY

Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde

(2013) Balazs Antus et al.   RESPIROLOGY

Adrenergic signaling and oxidative stress: a role for sirtuins?

(2013) Graziamaria Corbi et al.   Frontiers in Physiology

Targeted Deletion of Jun/AP-1 in Alveolar Epithelial Cells Causes Progressive Emphysema and Worsens Cigarette Smoke–Induced Lung Inflammation

(2012) Narsa M. Reddy et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts

(2012) Hisatoshi Sugiura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Antioxidant pharmacological therapies for COPD

(2012) Irfan Rahman et al.   CURRENT OPINION IN PHARMACOLOGY

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Properties of Sirtuin 6 in Human Umbilical Vein Endothelial Cells

(2012) Martha Lappas   MEDIATORS OF INFLAMMATION

Is Physical Activity Able to Modify Oxidative Damage in Cardiovascular Aging?

(2012) Graziamaria Corbi et al.   Oxidative Medicine and Cellular Longevity

The ARGA study with general practitioners: Impact of medical education on asthma/rhinitis management

(2012) Sandra Baldacci et al.   RESPIRATORY MEDICINE

Suppressed Expression of T-Box Transcription Factors Is Involved in Senescence in Chronic Obstructive Pulmonary Disease

(2012) George K. Acquaah-Mensah et al.   PLoS Computational Biology

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease

(2012) Kazuhiro Ito et al.   International Journal of Chronic Obstructive Pulmonary Disease

Telomere Length Is a Determinant of Emphysema Susceptibility

(2011) Jonathan K. Alder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

(2011) Deepti Malhotra et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

(2011) Ivana Stanojkovic et al.   RESPIRATORY MEDICINE

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway

(2010) Shin Makabe et al.   ATHEROSCLEROSIS

MMP9 modulates tight junction integrity and cell viability in human airway epithelia

(2009) Paola D. Vermeer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2009) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Peroxynitrite Elevation in Exhaled Breath Condensate of COPD and Its Inhibition by Fudosteine

(2009) Grace O. Osoata et al.   CHEST

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Nrf2 protects against airway disorders

(2009) Hye-Youn Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease

(2008) M. Bradley Drummond et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

(2008) Zhi-Hua Chen et al.   PLoS One

Aging and induced senescence as factors in the pathogenesis of lung emphysema

(2008) Stefan Karrasch et al.   RESPIRATORY MEDICINE

Exercise Training Promotes SIRT1 Activity in Aged Rats

(2007) Nicola Ferrara et al.   REJUVENATION RESEARCH