Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

(2013) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure and Evolution of Human Sirtuins

(2013) Domenico Bordo   CURRENT DRUG TARGETS

The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury

(2013) Hong Fan et al.   KIDNEY INTERNATIONAL

SIRT1 Expression Is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC

(2013) Tao Zhang et al.   PLoS One

Increased ectodomain shedding of lung epithelial cell adhesion molecule 1 as a cause of increased alveolar cell apoptosis in emphysema

(2013) Takahiro Mimae et al.   THORAX

Alveolar Epithelial Stem and Progenitor Cells: Emerging Evidence for their Role in Lung Regeneration

(2012) A. M. Hoffman et al.   CURRENT MEDICINAL CHEMISTRY

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma

(2012) TOMOMI ICHIKAWA et al.   RESPIROLOGY

Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A

(2012) Shyamala Ganesan et al.   THORAX

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice

(2011) Laszlo Farkas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Involvement of Creatine Kinase B in Cigarette Smoke–Induced Bronchial Epithelial Cell Senescence

(2011) Hiromichi Hara et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

(2011) Irfan Rahman et al.   PREVENTIVE MEDICINE

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Activation of hypoxia-inducible factor-1  via nuclear factor- B in rats with chronic obstructive pulmonary disease

(2010) H. Jiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Isolation of alveolar epithelial type II progenitor cells from adult human lungs

(2010) Naoya Fujino et al.   LABORATORY INVESTIGATION

Involvement of type II pneumocytes in the pathogenesis of chronic obstructive pulmonary disease

(2010) Chun-zhen Zhao et al.   RESPIRATORY MEDICINE

Pulmonary Emphysema Induced by Cigarette Smoke Solution and Lipopolysaccharide in Guinea Pigs

(2009) Nobuaki Mizutani et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Pathogénie de la bronchopneumopathie chronique obstructive

(2009) Pierre-Régis Burgel   PRESSE MEDICALE

Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smoke

(2009) Hongao Zheng et al.   TOXICOLOGY LETTERS

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia

(2008) Cyprian V. Weaver et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY