Mesenchymal Stem Cell‐Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

(2020) Han Young Kim et al.   BIOMATERIALS

Recent Clinical Trials in Adipose-derived Stem Cell Mediated Osteoarthritis Treatment

(2020) Hyeran Cho et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

(2019) Shipin Zhang et al.   BIOMATERIALS

The Pros and Cons of Mesenchymal Stem Cell-Based Therapies

(2019) Aleksandra Musiał-Wysocka et al.   CELL TRANSPLANTATION

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Exosome manufacturing status

(2019) William Whitford et al.   Future Medicinal Chemistry

Exosome-mediated Bidirectional Signaling between Mesenchymal Stem Cells and Chondrocytes for Enhanced Chondrogenesis

(2019) Young Guk Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

LncRNAs as Chromatin Regulators in Cancer: From Molecular Function to Clinical Potential

(2019) Rodiola Begolli et al.   Cancers

Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs

(2018) Christopher R. Rowland et al.   BIOMATERIALS

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Engineered Co-culture Strategies Using Stem Cells for Facilitated Chondrogenic Differentiation and Cartilage Repair

(2018) Hyeran Cho et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy

(2018) Yu-Hsun Chang et al.   CELL TRANSPLANTATION

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes

(2018) Miguel Tofiño-Vian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cartilage diseases

(2018) Yamini Krishnan et al.   MATRIX BIOLOGY

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

(2018) Lucienne A. Vonk et al.   Theranostics

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

(2018) Edwin E. Reza-Zaldivar et al.   Frontiers in Cellular Neuroscience

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

(2018) Yubao Liu et al.   BIOCHEMICAL JOURNAL

TGF-β1 promoted chondrocyte proliferation by regulating Sp1 through MSC-exosomes derived miR-135b

(2018) Rui Wang et al.   CELL CYCLE

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

(2017) Jose C. Contreras-Naranjo et al.   LAB ON A CHIP

Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration

(2017) Xiaolin Liu et al.   Nanoscale

MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation

(2017) G. Mao et al.   OSTEOARTHRITIS AND CARTILAGE

Definition of a Critical Size Osteochondral Knee Defect and its Negative Effect on the Surrounding Articular Cartilage in the Rat

(2017) H. Katagiri et al.   OSTEOARTHRITIS AND CARTILAGE

Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal stem cells and hyaluronic acid hydrogel composite

(2017) Y.B. Park et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Histopathologic comparison of condylar hyperplasia and condylar osteochondroma by using different staining methods

(2017) Huanzhong Ji et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis

(2017) Lei Chen et al.   PLoS One

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

(2017) Sheng Zhou et al.   Scientific Reports

Tissue-Integratable and Biocompatible Photogelation by the Imine Crosslinking Reaction

(2016) Yunlong Yang et al.   ADVANCED MATERIALS

PKCδnull mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth

(2016) Ranjan Kc et al.   ANNALS OF THE RHEUMATIC DISEASES

Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model

(2016) Jang Won Park et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

(2016) S. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

(2016) Jieyuan Zhang et al.   Stem Cell Research & Therapy

Animal models of osteoarthritis: classification, update, and measurement of outcomes

(2016) Emmanuel L. Kuyinu et al.   Journal of Orthopaedic Surgery and Research

An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair

(2016) Jieyuan Zhang et al.   Journal of Materials Chemistry B

Sp1 upregulates the proximal promoter activity of the mouse collagen α1(XI) gene (Col11a1) in chondrocytes

(2015) Keijirou Watanabe et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Pore orientation mediated control of mechanical behavior of scaffolds and its application in cartilage-mimetic scaffold design

(2015) Aditya Arora et al.   Journal of the Mechanical Behavior of Biomedical Materials

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

(2015) Jieyuan Zhang et al.   Journal of Translational Medicine

In Vivo Evaluation of a Novel Oriented Scaffold-BMSC Construct for Enhancing Full-Thickness Articular Cartilage Repair in a Rabbit Model

(2015) Shuaijun Jia et al.   PLoS One

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal Models of Osteoarthritis

(2015) A. M. McCoy   VETERINARY PATHOLOGY

The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology

(2014) John K. C. Chan   INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Neutrophil-Derived Cytokines: Facts Beyond Expression

(2014) Cristina Tecchio et al.   Frontiers in Immunology

Dual functions for WNT5A during cartilage development and in disease

(2013) Sara Hosseini-Farahabadi et al.   MATRIX BIOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular matrix as an inductive scaffold for functional tissue reconstruction

(2013) Bryan N. Brown et al.   Translational Research

Familial Occurrence of Pulmonary Embolism after Intravenous, Adipose Tissue-Derived Stem Cell Therapy

(2013) Jae Woo Jung et al.   YONSEI MEDICAL JOURNAL

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Emerging Frontiers in cartilage and chondrocyte biology

(2012) Amanda J. Fosang et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The impact of PLGA scaffold orientation on in vitro cartilage regeneration

(2012) Yingying Zhang et al.   BIOMATERIALS

Etiology of osteoarthritis: genetics and synovial joint development

(2012) Linda J. Sandell   Nature Reviews Rheumatology

Histopathology of naturally occurring and surgically induced osteoarthritis in mice

(2012) M.A. McNulty et al.   OSTEOARTHRITIS AND CARTILAGE

Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in knee joints of mouse models of OA

(2012) Y. Li et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells

(2011) Kyobum Kim et al.   BIOMATERIALS

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

MiR-140 is co-expressed withWwp2-Ctranscript and activated by Sox9 to targetSp1in maintaining the chondrocyte proliferation

(2011) Jun Yang et al.   FEBS LETTERS

A proposed model of naturally occurring osteoarthritis in the domestic rabbit

(2011) Boaz Arzi et al.   LAB ANIMAL

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

(2010) Frank Beier et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Basic methods in histopathology of joint tissues

(2010) N. Schmitz et al.   OSTEOARTHRITIS AND CARTILAGE

Mouse Bone Marrow-Derived Mesenchymal Stromal Cells Turn Activated Macrophages into a Regulatory-Like Profile

(2010) Julian Maggini et al.   PLoS One

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Microfracture

(2010) J. Richard Steadman et al.   Cartilage

Prostaglandin E2and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis

(2009) Xin Li et al.   ARTHRITIS AND RHEUMATISM

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage

(2009) M. Rutgers et al.   OSTEOARTHRITIS AND CARTILAGE