Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

Linking mitochondrial dysfunction to organismal and population health in context of environmental pollutants: Progress and considerations for mitochondrial adverse outcome pathways

(2019) David A. Dreier et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

(2019) Johannes Delp et al.   ARCHIVES OF TOXICOLOGY

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

(2019) Steven Hiemstra et al.   ARCHIVES OF TOXICOLOGY

In vitro screening of cell bioenergetics to assess mitochondrial dysfunction in drug development

(2018) K. Tilmant et al.   TOXICOLOGY IN VITRO

The catechol- O -methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells

(2017) David Grünig et al.   TOXICOLOGY IN VITRO

A combined in vitro approach to improve the prediction of mitochondrial toxicants

(2016) Julie Eakins et al.   TOXICOLOGY IN VITRO

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

(2015) K Kluckova et al.   Cell Death & Disease

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

(2015) J Pfleger et al.   Cell Death & Disease

The Split-Apply-Combine Strategy for Data Analysis

(2015) Hadley Wickham   Journal of Statistical Software

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

(2014) Sreenivasa C. Ramaiahgari et al.   ARCHIVES OF TOXICOLOGY

Structural Basis of Resistance to Anti-Cytochrome bc1 Complex Inhibitors: Implication for Drug Improvement

(2014) Lothar Esser et al.   CURRENT PHARMACEUTICAL DESIGN

Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis

(2014) Joshua K Salabei et al.   Nature Protocols

Comparative Kinetics ofQiSite Inhibitors of Cytochromebc1Complex: Picomolar Antimycin and Micromolar Cyazofamid

(2013) Hui Li et al.   Chemical Biology & Drug Design

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation

(2013) L. Aschauer et al.   MOLECULAR AND CELLULAR BIOLOGY

A Review of Current Knowledge of Resistance Aspects for the Next-Generation Succinate Dehydrogenase Inhibitor Fungicides

(2013) Helge Sierotzki et al.   PHYTOPATHOLOGY

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening

(2012) Zi Di et al.   PLoS One

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

(2011) Alice Limonciel et al.   TOXICOLOGY IN VITRO

Quinone binding and reduction by respiratory complex I

(2010) Maja A. Tocilescu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of Escherichia coli Succinate:Quinone Oxidoreductase with an Occupied and Empty Quinone-binding Site

(2009) Jonathan Ruprecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subnanomolar Inhibitor of Cytochromebc1Complex Designed by Optimizing Interaction with Conformationally Flexible Residues

(2009) Pei-Liang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Simultaneous Inference in General Parametric Models

(2008) Torsten Hothorn et al.   BIOMETRICAL JOURNAL