TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation

Spatial and temporal control of NODAL signaling

(2018) Caroline S Hill   CURRENT OPINION IN CELL BIOLOGY

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

(2018) Anassuya Ramachandran et al.   eLife

The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery

(2018) Daniel S.J. Miller et al.   Cell Reports

TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment

(2017) Michael W. Pickup et al.   Cold Spring Harbor Perspectives in Biology

Systems biology derived source-sink mechanism of BMP gradient formation

(2017) Joseph Zinski et al.   eLife

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling

(2017) Davide M Coda et al.   eLife

Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

(2017) Autumn P Pomreinke et al.   eLife

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

The Discovery and Early Days of TGF-β: A Historical Perspective

(2016) Harold L. Moses et al.   Cold Spring Harbor Perspectives in Biology

Structure and activation of pro-activin A

(2016) Xuelu Wang et al.   Nature Communications

Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes

(2015) Kangmin He et al.   CELL RESEARCH

A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain

(2015) Antonius L. van Boxtel et al.   DEVELOPMENTAL CELL

Structure of bone morphogenetic protein 9 procomplex

(2015) Li-Zhi Mi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

BMP signalling: agony and antagony in the family

(2015) Derek P. Brazil et al.   TRENDS IN CELL BIOLOGY

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

BioModels: ten-year anniversary

(2014) Vijayalakshmi Chelliah et al.   NUCLEIC ACIDS RESEARCH

The activins and their binding protein, follistatin—Diagnostic and therapeutic targets in inflammatory disease and fibrosis

(2013) M.P. Hedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands

(2013) Marie-Christine Ramel et al.   DEVELOPMENTAL BIOLOGY

Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-  Pathway

(2013) P. Vizan et al.   Science Signaling

Activin signaling as an emerging target for therapeutic interventions

(2012) Kunihiro Tsuchida et al.   Cell Communication and Signaling

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily

(2012) Andrew P. Hinck   FEBS LETTERS

Transforming Growth Factor   Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes

(2012) E. Gronroos et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Robustness in angiogenesis: Notch and BMP shaping waves

(2012) Karen Beets et al.   TRENDS IN GENETICS

Maternal and Zygotic Control of Zebrafish Dorsoventral Axial Patterning

(2011) Yvette G. Langdon et al.   Annual Review of Genetics

Temporal dynamics of patterning by morphogen gradients

(2009) Eva Kutejova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An Anti-Transforming Growth Factor   Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

(2008) J.-S. Nam et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding

(2008) Jay Groppe et al.   MOLECULAR CELL

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

(2008) B. Schmierer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding the quantitative nature of TGF-β/Smad signaling

(2008) David C. Clarke et al.   TRENDS IN CELL BIOLOGY