Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells

Mitochondrial Biogenesis and Mitochondrial Reactive Oxygen Species (ROS): A Complex Relationship Regulated by the cAMP/PKA Signaling Pathway

(2019) Cyrielle Bouchez et al.   Cells

The Expanding and Unexpected Functions of Mitochondria Contact Sites

(2019) Laura L. Lackner   TRENDS IN CELL BIOLOGY

The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies

(2019) Taylor Harding et al.   LEUKEMIA

Neuromuscular Plasticity in a Mouse Neurotoxic Model of Spinal Motoneuronal Loss

(2019) Rosario Gulino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Wild-Type IDH Enzymes as Actionable Targets for Cancer Therapy

(2019) Elisa Bergaggio et al.   Cancers

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

Compensatory changes in degenerating spinal motoneurons sustain functional sparing in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis

(2019) Elena Giusto et al.   JOURNAL OF COMPARATIVE NEUROLOGY

MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair

(2019) Penelope D. Ruiz et al.   MOLECULAR AND CELLULAR BIOLOGY

Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons

(2019) Ping Lu et al.   NEUROPHARMACOLOGY

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Evaluation of mitochondrial redox status and energy metabolism of X-irradiated HeLa cells by LC/UV, LC/MS/MS and ESR

(2018) Kumiko Yamamoto et al.   FREE RADICAL RESEARCH

O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance

(2018) Yubo Liu et al.   Cell Death & Disease

Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells

(2018) Min Jung Kong et al.   Cell Death & Disease

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis

(2018) Francesca Ricciardiello et al.   Cell Death & Disease

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Drug resistance in multiple myeloma

(2018) Pawel Robak et al.   CANCER TREATMENT REVIEWS

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

(2018) Kekoa Taparra et al.   JOURNAL OF CLINICAL INVESTIGATION

Hexosamine Biosynthetic Pathway Inhibition Leads to AML Cell Differentiation and Cell Death

(2018) Abhishek Asthana et al.   MOLECULAR CANCER THERAPEUTICS

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

(2018) In-geun Ryoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling

(2018) Gentry K. Cork et al.   Frontiers in Endocrinology

IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies

(2018) Elisa Bergaggio et al.   BLOOD

Current understanding of the potential of proteomics and metabolomics approaches in cancer chemoresistance: A focus on Multiple Myeloma

(2018) Venkatesh Chanukuppa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The power of proteasome inhibition in multiple myeloma

(2018) Thomas A. Guerrero-Garcia et al.   Expert Review of Proteomics

Contemporary patient-tailored treatment strategies against high risk and relapsed or refractory multiple myeloma

(2018) Fatih M. Uckun et al.   EBioMedicine

SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells

(2017) Pengyun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MitochondrialO-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells

(2017) Juliana L. Sacoman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for dolichylphosphate mannose biosynthesis

(2017) Rosaria Gandini et al.   Nature Communications

Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells

(2017) Ravyn M. Thompson et al.   Oncotarget

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Proteasome subunit expression analysis and chemosensitivity in relapsed paediatric acute leukaemia patients receiving bortezomib-containing chemotherapy

(2016) Denise Niewerth et al.   Journal of Hematology & Oncology

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

(2016) G P Soriano et al.   LEUKEMIA

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

(2016) Daniele Tibullo et al.   Oncotarget

Nicotinamide Phosphoribosyltransferase and SirT3 Expression are increased in Well-Differentiated Thyroid Carcinomas

(2016) Rodney Shackelford et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma

(2015) P. Maiso et al.   CANCER RESEARCH

Increased expression of mitochondrial DNA-encoded genes in human renal mesangial cells in response to high glucose-induced reactive oxygen species

(2015) GHADA AL-KAFAJI et al.   Molecular Medicine Reports

The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation

(2014) David R. Jones et al.   FEBS Journal

N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response

(2014) Ping He et al.   GLYCOBIOLOGY

Glycosylation of the Nuclear Pore

(2014) Bin Li et al.   TRAFFIC

Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties

(2013) Ritsuko Seki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity

(2013) A. Cagnetta et al.   BLOOD

The Glycome of Normal and Malignant Plasma Cells

(2013) Thomas M. Moehler et al.   PLoS One

Mitochondrial Dysfunction and NAD+ Metabolism Alterations in the Pathophysiology of Acute Brain Injury

(2013) Katrina Owens et al.   Translational Stroke Research

Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells

(2011) N E Franke et al.   LEUKEMIA

The role of SirT1 in muscle mitochondrial turnover

(2011) Keir J. Menzies et al.   MITOCHONDRION

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period

(2010) I. Baranowska-Bosiacka et al.   TOXICOLOGY

Characterization of the ubiquitin–proteasome system in bortezomib-adapted cells

(2009) T Rückrich et al.   LEUKEMIA

Symbol nomenclature for glycan representation

(2009) Ajit Varki et al.   PROTEOMICS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

(2008) H. Gu et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY