- Home
- Publications
- Publication Search
- Publication Details
Title
Wild-Type IDH Enzymes as Actionable Targets for Cancer Therapy
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 4, Pages 563
Publisher
MDPI AG
Online
2019-04-22
DOI
10.3390/cancers11040563
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biological Role and Therapeutic Potential of IDH Mutations in Cancer
- (2018) Matthew S. Waitkus et al. CANCER CELL
- Wild-Type Isocitrate Dehydrogenase 1 Over-Expression is Related to Cancer Stem Cells Survival in Lung Adenocarcinoma
- (2018) Hiba Saeed A. Bagader Al-Amodi et al. CANCER INVESTIGATION
- Wild-type and mutated IDH1/2 enzymes and therapy responses
- (2018) Remco J. Molenaar et al. ONCOGENE
- Ivosidenib in IDH1-Mutated Acute Myeloid Leukemia
- (2018) NEW ENGLAND JOURNAL OF MEDICINE
- Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer
- (2018) Jiangjiang Li et al. Theranostics
- IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
- (2018) Elisa Bergaggio et al. BLOOD
- Drug development in the era of precision medicine
- (2017) Sarah A. Dugger et al. NATURE REVIEWS DRUG DISCOVERY
- Whole-Exome Sequencing Identifies Biallelic IDH3A Variants as a Cause of Retinitis Pigmentosa Accompanied by Pseudocoloboma
- (2017) Laurence H.M. Pierrache et al. OPHTHALMOLOGY
- Idh2 Deficiency Exacerbates Acrolein-Induced Lung Injury through Mitochondrial Redox Environment Deterioration
- (2017) Jung Hyun Park et al. Oxidative Medicine and Cellular Longevity
- IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced
- (2017) Huixia Zhu et al. PLoS One
- Metabolomic and proteomic investigations of impacts of titanium dioxide nanoparticles on Escherichia coli
- (2017) Mariane Planchon et al. PLoS One
- Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling
- (2017) Laurence M. Gagné et al. TRENDS IN CELL BIOLOGY
- Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
- (2017) Hamoud Al-Khallaf Cell and Bioscience
- Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
- (2017) Andrea E. Calvert et al. Cell Reports
- Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
- (2017) Demian van Straten et al. Cancers
- The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
- (2017) Tengfei Ma et al. Scientific Reports
- Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis
- (2016) Daniel R. Wahl et al. CANCER RESEARCH
- Pheochromocytoma: The First Metabolic Endocrine Cancer
- (2016) I. Jochmanova et al. CLINICAL CANCER RESEARCH
- SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production
- (2016) Margalida Torrens-Mas et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas
- (2016) Jun-Rui Chen et al. MEDICINE
- Isocitrate Dehydrogenase 2 Suppresses the Invasion of Hepatocellular Carcinoma Cells via Matrix Metalloproteinase 9
- (2015) Guo-Yan Tian et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- HighIDH1expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia
- (2015) Qiu-Ling Ma et al. INTERNATIONAL JOURNAL OF CANCER
- Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer
- (2015) JUN KOSEKI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
- (2015) Suzana Markolovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies
- (2015) Wei Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms
- (2015) R J Molenaar et al. LEUKEMIA
- IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
- (2015) C D DiNardo et al. LEUKEMIA
- Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes
- (2015) Yonghui Jin et al. PLoS One
- MutantIDHis sufficient to initiate enchondromatosis in mice
- (2015) Makoto Hirata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isocitrate dehydrogenase 2 inhibits gastric cancer cell invasion via matrix metalloproteinase 7
- (2015) Dandan Wu TUMOR BIOLOGY
- IDH1 Overexpression Induced Chemotherapy Resistance and IDH1 Mutation Enhanced Chemotherapy Sensitivity in Glioma Cells in Vitro and in Vivo
- (2014) Ju-Bo Wang et al. Asian Pacific Journal of Cancer Prevention
- D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice
- (2014) E. A. Akbay et al. GENES & DEVELOPMENT
- High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma
- (2014) Wei-Ren Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis
- (2014) L Zeng et al. ONCOGENE
- NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells
- (2014) Shigeru Yamada et al. Scientific Reports
- Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death
- (2013) Isabelle Vanessa Mohrenz et al. APOPTOSIS
- Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances glioma radiosensitivity
- (2013) Sung Youl Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Suppression of tumorigenesis in mitochondrial NADP+-dependent isocitrate dehydrogenase knock-out mice
- (2013) Seontae Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Intracellular NAD+ depletion enhances bortezomib-induced anti-myeloma activity
- (2013) A. Cagnetta et al. BLOOD
- Isocitrate Dehydrogenase 1 Is a Novel Plasma Biomarker for the Diagnosis of Non-Small Cell Lung Cancer
- (2013) N. Sun et al. CLINICAL CANCER RESEARCH
- Novel cases of D-2-hydroxyglutaric aciduria withIDH1orIDH2mosaic mutations identified by amplicon deep sequencing
- (2013) Benjamin Nota et al. JOURNAL OF MEDICAL GENETICS
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
- (2013) Sarah-Maria Fendt et al. Nature Communications
- Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1
- (2013) Xing Liu et al. Cancer Medicine
- Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
- (2012) Marcel Deponte BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase
- (2012) Delira Robbins et al. CANCER SCIENCE
- Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
- (2012) Christine Guo Lian et al. CELL
- IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
- (2012) H. Yang et al. CLINICAL CANCER RESEARCH
- SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status
- (2012) Wei Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantitative proteome analysis of ovarian cancer tissues using a iTRAQ approach
- (2012) Li-Na Wang et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells
- (2012) Hirotomo Tanaka et al. JOURNAL OF NEURO-ONCOLOGY
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation
- (2012) Sichen Li et al. NEURO-ONCOLOGY
- Altered expression levels of IDH2 are involved in the development of colon cancer
- (2012) QIANG LV et al. Experimental and Therapeutic Medicine
- Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA)
- (2011) Lisenka E.L.M. Vissers et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Mutant IDH1 Confers an in Vivo Growth in a Melanoma Cell Line with BRAF Mutation
- (2011) Tatsuhiro Shibata et al. AMERICAN JOURNAL OF PATHOLOGY
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Comparative Metabolic Flux Profiling of Melanoma Cell Lines
- (2011) David A. Scott et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
- (2011) M Fernanda Amary et al. JOURNAL OF PATHOLOGY
- Identification of Isocitrate Dehydrogenase 1 as a Potential Diagnostic and Prognostic Biomarker for Non-small Cell Lung Cancer by Proteomic Analysis
- (2011) Fengwei Tan et al. MOLECULAR & CELLULAR PROTEOMICS
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
- (2011) Andrew R. Mullen et al. NATURE
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2
- (2011) M Fernanda Amary et al. NATURE GENETICS
- Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
- (2011) Twinkal C Pansuriya et al. NATURE GENETICS
- IDH mutation status in prostate cancer
- (2011) A F Ghiam et al. ONCOGENE
- Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping
- (2011) D. R. Borger et al. ONCOLOGIST
- Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of -ketoglutarate to citrate to support cell growth and viability
- (2011) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
- (2010) Avaniyapuram Kannan Murugan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Thioredoxin and thioredoxin reductase: Current research with special reference to human disease
- (2010) Arne Holmgren et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
- (2010) Peter Paschka et al. JOURNAL OF CLINICAL ONCOLOGY
- IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
- (2010) A Tefferi et al. LEUKEMIA
- IDH1 and IDH2 mutation analysis in chronic- and blast-phase myeloproliferative neoplasms
- (2010) A Pardanani et al. LEUKEMIA
- IDH2 Mutations in Patients with D-2-Hydroxyglutaric Aciduria
- (2010) M. Kranendijk et al. SCIENCE
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria
- (2009) Martijn Kranendijk et al. HUMAN MUTATION
- Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
- (2009) Mi Ran Kang et al. INTERNATIONAL JOURNAL OF CANCER
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
- Use of gene expression profiles to stage concurrent endometrioid tumors of the endometrium and ovary
- (2008) Alfred Guirguis et al. GYNECOLOGIC ONCOLOGY
- Expanding chemical biology of 2-oxoglutarate oxygenases
- (2008) Christoph Loenarz et al. Nature Chemical Biology
- Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
- (2008) Dyonne T Hartong et al. NATURE GENETICS
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
- NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
- (2007) Weihai Ying ANTIOXIDANTS & REDOX SIGNALING
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started