An Extract of Transgenic Senna obtusifolia L. hairy roots with Overexpression of PgSS1 Gene in Combination with Chemotherapeutic Agent Induces Apoptosis in the Leukemia Cell Line

Betulinic acid restores imatinib sensitivity in BCR‐ABL1 kinase−independent, imatinib‐resistant chronic myeloid leukemia by increasing HDAC3 ubiquitination and degradation

(2020) Tingting Lu et al.   Annals of the New York Academy of Sciences

Enhanced flavonoid production in hairy root cultures of Scutellaria bornmuelleri by elicitor induced over-expression of MYB7 and FNSП2 genes

(2020) Zahra Gharari et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Transgenesis as a Tool for the Efficient Production of Selected Secondary Metabolites from Plant in Vitro Cultures

(2020) Tomasz Kowalczyk et al.   Plants-Basel

Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells

(2019) Tomasz Kowalczyk et al.   CYTOTECHNOLOGY

Enhancement of tanshinone production in Salvia miltiorrhiza hairy root cultures by metabolic engineering

(2019) Tao Wei et al.   Plant Methods

Cancer treatment and survivorship statistics, 2019

(2019) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures

(2019) Mihir Halder et al.   ENGINEERING IN LIFE SCIENCES

Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice

(2019) Sonja Schötterl et al.   Evidence-based Complementary and Alternative Medicine

Medicinal plants and bioactive natural compounds for cancer treatment: Important advances for drug discovery

(2019) Fernanda Majolo et al.   Phytochemistry Letters

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

(2019) Anna Hordyjewska et al.   PHYTOCHEMISTRY REVIEWS

Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family

(2019) Zahra Aminfar et al.   Scientific Reports

Heterologous expression of an acid phosphatase gene and phosphate limitation leads to substantial production of chicoric acid in Echinacea purpurea transgenic hairy roots

(2019) Meisam Salmanzadeh et al.   PLANTA

Sensitization of tumor cells to chemotherapy by natural products: A systematic review of preclinical data and molecular mechanisms

(2018) Raimundo Gonçalves de Oliveira Júnior et al.   FITOTERAPIA

In vitro plant tissue culture: means for production of biological active compounds

(2018) Claudia A. Espinosa-Leal et al.   PLANTA

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Asteriscus graveolens Extract in Combination with Cisplatin/Etoposide/Doxorubicin Suppresses Lymphoma Cell Growth through Induction of Caspase-3 Dependent Apoptosis

(2018) Zainab Tayeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An In Vitro Estimation of the Cytotoxicity and Genotoxicity of Root Extract from Leonurus sibiricus L. Overexpressing AtPAP1 against Different Cancer Cell Lines

(2018) Przemysław Sitarek et al.   MOLECULES

Plant-specific transcription factor LrTCP4 enhances secondary metabolite biosynthesis in Lycium ruthenicum hairy roots

(2018) Aysha Arif Chahel et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Over-Expression of AtPAP1 Transcriptional Factor Enhances Phenolic Acid Production in Transgenic Roots of Leonurus sibiricus L. and Their Biological Activities

(2017) Przemysław Sitarek et al.   MOLECULAR BIOTECHNOLOGY

Genetically engineered hairy root cultures of Hyoscyamus senecionis and H. muticus: ploidy as a promising parameter in the metabolic engineering of tropane alkaloids

(2017) Esmaeil Dehghan et al.   PLANT CELL REPORTS

Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield

(2017) Tasiu Isah et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Heterologous production of a ginsenoside saponin (compound K) and its precursors in transgenic tobacco impairs the vegetative and reproductive growth

(2017) Yu Shin Gwak et al.   PLANTA

Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering

(2016) Min Shi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Exploring the Metabolic Stability of Engineered Hairy Roots after 16 Years Maintenance

(2016) Suvi T. Häkkinen et al.   Frontiers in Plant Science

Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants

(2016) Lei Yang et al.   Science Bulletin

Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy

(2015) Mohamed Ali-Seyed et al.   Chemical Biology & Drug Design

Plants as Factories for Human Pharmaceuticals: Applications and Challenges

(2015) Jian Yao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anticancer potential of medicinal plants and their phytochemicals: a review

(2015) Shruti Shukla et al.   Brazilian Journal of Botany

Enhanced levels of S-linalool by metabolic engineering of the terpenoid pathway in spike lavender leaves

(2014) Isabel Mendoza-Poudereux et al.   METABOLIC ENGINEERING

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3

(2012) Eun-Jung Park et al.   PLoS One

NOXA as critical mediator for drug combinations in polychemotherapy

(2012) H Ehrhardt et al.   Cell Death & Disease

Overexpression of the Arabidopsis thaliana squalene synthase gene in Withania coagulans hairy root cultures

(2011) M. H. Mirjalili et al.   BIOLOGIA PLANTARUM

Optimization of extraction techniques and quantification of Betulinic Acid (BA) by RP-HPLC method from Ancistrocladus heyneanus Wall. Ex Grah.

(2011) Sandeep R. Pai et al.   INDUSTRIAL CROPS AND PRODUCTS

Physico-chemical comparison of betulinic acid, betulin and birch bark extract andin vitroinvestigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines

(2011) Codruta M. Şoica et al.   NATURAL PRODUCT RESEARCH

Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines

(2009) Marcin Drag et al.   MOLECULES

Transcription-independent p53 apoptosis: an alternative route to death

(2009) Daniel Speidel   TRENDS IN CELL BIOLOGY