BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development

Impaired SMAD1/5 Mechanotransduction and Cx37 (Connexin37) Expression Enable Pathological Vessel Enlargement and Shunting

(2020) Hanna M. Peacock et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Venous identity requires BMP signalling through ALK3

(2019) Alice Neal et al.   Nature Communications

Vascular deficiency of Smad4 causes arteriovenous malformations: a mouse model of Hereditary Hemorrhagic Telangiectasia

(2018) Angela M. Crist et al.   ANGIOGENESIS

SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2

(2018) Roxana Ola et al.   CIRCULATION

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression

(2018) Anne-Clémence Vion et al.   JOURNAL OF CELL BIOLOGY

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2

(2018) Jérémy H. Thalgott et al.   CIRCULATION

SMAD4 Deficiency Leads to Development of Arteriovenous Malformations in Neonatal and Adult Mice

(2018) Yong Hwan Kim et al.   Journal of the American Heart Association

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence

(2017) Andreas Benn et al.   FASEB JOURNAL

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

(2017) Yi Jin et al.   NATURE CELL BIOLOGY

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

(2017) A. V. Shah et al.   Nature Communications

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

(2016) Nicolas Baeyens et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of Vessel Pruning and Regression

(2015) Claudia Korn et al.   DEVELOPMENTAL CELL

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression

(2015) Claudio A. Franco et al.   PLOS BIOLOGY

Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

(2015) Simon Tual-Chalot et al.   Frontiers in Genetics

Intussusceptive angiogenesis: expansion and remodeling of microvascular networks

(2014) Steven J. Mentzer et al.   ANGIOGENESIS

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

(2013) Alisha Holtzhausen et al.   FASEB JOURNAL

BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow

(2013) J. Zhou et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

(2012) F. Itoh et al.   BLOOD

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

(2012) Ward De Spiegelaere et al.   JOURNAL OF VASCULAR RESEARCH

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina

(2010) Alyssa C. Taylor et al.   MICROVASCULAR RESEARCH

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD