Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence

A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

(2016) Antonio Jimeno et al.   CANCER

BMP signaling in vascular biology and dysfunction

(2016) Amaya García de Vinuesa et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

(2016) Kevin P. Mouillesseaux et al.   Nature Communications

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

(2015) Georgina Kerr et al.   ANGIOGENESIS

Does cellular sex matter? Dimorphic transcriptional differences between female and male endothelial cells

(2015) Mario Lorenz et al.   ATHEROSCLEROSIS

Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer

(2015) S. I. Cunha et al.   CANCER RESEARCH

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

(2015) L. J. A. C. Hawinkels et al.   CLINICAL CANCER RESEARCH

Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish

(2015) Yuki Wakayama et al.   DEVELOPMENTAL CELL

Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study 0229N

(2015) Vicky Makker et al.   GYNECOLOGIC ONCOLOGY

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling

(2015) Andreas Benn et al.   JOURNAL OF CELL SCIENCE

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia

(2015) Emmanuelle Tillet et al.   Frontiers in Genetics

BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex

(2014) Christian Hiepen et al.   BMC BIOLOGY

TGF-β& BMP Receptors Endoglin and ALK1: Overview of their Functional Role and Status as Antiangiogenic Targets

(2014) Leon Jonker   MICROCIRCULATION

Bevacizumab and micrometastases: Revisiting the preclinical and clinical rollercoaster

(2013) Giannis Mountzios et al.   PHARMACOLOGY & THERAPEUTICS

A New Class of Small Molecule Inhibitor of BMP Signaling

(2013) Caroline E. Sanvitale et al.   PLoS One

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

(2013) Jonathan Crowe et al.   PLoS One

Bone Morphogenetic Protein 7 Increased Vascular Endothelial Growth Factor (VEGF)-A Expression in Human Granulosa Cells and VEGF Receptor Expression in Endothelial Cells

(2013) Ikumi Akiyama et al.   Reproductive Sciences

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6

(2013) Su Myung Jung et al.   Nature Communications

The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward

(2013) M. W. Kieran et al.   Cold Spring Harbor Perspectives in Medicine

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

(2012) Laurens A. van Meeteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SMADversusNon-SMAD Signaling Is Determined by Lateral Mobility of Bone Morphogenetic Protein (BMP) Receptors

(2012) Asja Guzman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of bone morphogenetic protein 2 on human umbilical vein endothelial cells

(2012) G. Finkenzeller et al.   MICROVASCULAR RESEARCH

ALK1 as an emerging target for antiangiogenic therapy of cancer

(2011) S. I. Cunha et al.   BLOOD

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

TimeLapseAnalyzer: Multi-target analysis for live-cell imaging and time-lapse microscopy

(2011) Johannes Huth et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Efficient Computation, Sensitivity, and Error Analysis of Committor Probabilities for Complex Dynamical Processes

(2011) Jan-Hendrik Prinz et al.   MULTISCALE MODELING & SIMULATION

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein

(2011) David M. Wiley et al.   NATURE CELL BIOLOGY

Use of the mouse aortic ring assay to study angiogenesis

(2011) Marianne Baker et al.   Nature Protocols

The p38/MK2/Hsp25 Pathway Is Required for BMP-2-Induced Cell Migration

(2011) Cristina Gamell et al.   PLoS One

A Steering Model of Endothelial Sheet Migration Recapitulates Monolayer Integrity and Directed Collective Migration

(2010) P. Vitorino et al.   MOLECULAR AND CELLULAR BIOLOGY

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

Control of endothelial sprouting by a Tel–CtBP complex

(2010) M. Guy Roukens et al.   NATURE CELL BIOLOGY

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Mechanisms of Vessel Branching

(2009) Frederik De Smet et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intricacies of BMP receptor assembly

(2009) Joachim Nickel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Recent advances in BMP receptor signaling

(2009) Christina Sieber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

(2009) Vinicio A. de Jesus Perez et al.   JOURNAL OF CELL BIOLOGY

Transition Path Theory for Markov Jump Processes

(2009) Philipp Metzner et al.   MULTISCALE MODELING & SIMULATION

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE