Mouse models of hereditary hemorrhagic telangiectasia: recent advances and future challenges

VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2

(2014) Chul Han et al.   ANGIOGENESIS

Common and Distinctive Pathogenetic Features of Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia 1 and Hereditary Hemorrhagic Telangiectasia 2 Animal Models—Brief Report

(2014) Eva M. Garrido-Martin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

(2014) C. Mallet et al.   HUMAN MOLECULAR GENETICS

Novel Brain Arteriovenous Malformation Mouse Models for Type 1 Hereditary Hemorrhagic Telangiectasia

(2014) Eun-Jung Choi et al.   PLoS One

Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression

(2014) Simon Tual-Chalot et al.   PLoS One

Endoglin Deficiency Impairs Stroke Recovery

(2014) Fanxia Shen et al.   STROKE

De Novo Cerebrovascular Malformation in the Adult Mouse After Endothelial Alk1 Deletion and Angiogenic Stimulation

(2014) Wanqiu Chen et al.   STROKE

Bevacizumab in the treatment of hereditary hemorrhagic telangiectasia

(2013) Theoni Kanellopoulou et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Hereditary hemorrhagic telangiectasia in Japanese patients

(2013) Masaki Komiyama et al.   JOURNAL OF HUMAN GENETICS

Endoglin Deficiency in Bone Marrow is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse After Vascular Endothelial Growth Factor Stimulation

(2013) Eun-Jung Choi et al.   STROKE

Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1 -deficient Brain

(2012) Wanqiu Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Minimal Homozygous Endothelial Deletion of Eng with VEGF Stimulation Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse

(2012) Eun-Jung Choi et al.   CEREBROVASCULAR DISEASES

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Age-Dependent Lethality in Novel Transgenic Mouse Models of Central Nervous System Arteriovenous Malformations

(2012) Ian Milton et al.   STROKE

Bevacizumab Attenuates VEGF-Induced Angiogenesis and Vascular Malformations in the Adult Mouse Brain

(2012) Espen J. Walker et al.   STROKE

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

(2011) S. Goossens et al.   BLOOD

Interaction between alk1 and blood flow in the development of arteriovenous malformations

(2011) P. Corti et al.   DEVELOPMENT

Arteriovenous malformation in the adult mouse brain resembling the human disease

(2010) Espen J. Walker et al.   ANNALS OF NEUROLOGY

Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations

(2010) N. Ricard et al.   BLOOD

Hereditary haemorrhagic telangiectasia: Pathophysiology, diagnosis and treatment

(2010) Claire L. Shovlin   BLOOD REVIEWS

Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis

(2010) L. J. A. C. Hawinkels et al.   CANCER RESEARCH

Pathogenesis of Arteriovenous Malformations in the Absence of Endoglin

(2010) Marwa Mahmoud et al.   CIRCULATION RESEARCH

Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in endoglin heterozygous mice

(2010) Mirjana Jerkic et al.   INFLAMMATORY BOWEL DISEASES

Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia

(2010) Franck Lebrin et al.   NATURE MEDICINE

VEGF Induces More Severe Cerebrovascular Dysplasia in Eng+/− than in Alk1+/− Mice

(2010) Qi Hao et al.   Translational Stroke Research

Soluble endoglin modulates aberrant cerebral vascular remodeling

(2009) Yongmei Chen et al.   ANNALS OF NEUROLOGY

From germline towards somatic mutations in the pathophysiology of vascular anomalies

(2009) N. Limaye et al.   HUMAN MOLECULAR GENETICS

Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia

(2009) Sung Ok Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

(2008) Amy L. Akers et al.   HUMAN MOLECULAR GENETICS

Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations

(2008) Nisha Limaye et al.   NATURE GENETICS

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

(2007) S. O. Park et al.   BLOOD