JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Autophagy Inhibition Promotes 5-Fluorouraci-Induced Apoptosis by Stimulating ROS Formation in Human Non-Small Cell Lung Cancer A549 Cells

(2013) Xiaohong Pan et al.   PLoS One

c-Jun N-terminal kinase is required for thermotherapy-induced apoptosis in human gastric cancer cells

(2013) Feng Xiao   WORLD JOURNAL OF GASTROENTEROLOGY

Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation

(2013) A Notte et al.   Cell Death & Disease

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration

(2012) Jung-Hye Choi et al.   APMIS

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

(2012) Salome Paillas et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl tetrasulfide-induced mitotic arrest to apoptosis

(2012) Mareike Kelkel et al.   CARCINOGENESIS

Cross-talk of alpha tocopherol-associated protein and JNK controls the oxidative stress-induced apoptosis in prostate cancer cells

(2012) Baoyi Zhu et al.   INTERNATIONAL JOURNAL OF CANCER

Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers

(2012) Xiaotong Hu et al.   JOURNAL OF PATHOLOGY

The Role of Bcl-xL in Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia on Human Colon Cancer

(2012) X. Song et al.   MOLECULAR CANCER RESEARCH

Gene Silencing of FANCF Potentiates the Sensitivity to Mitoxantrone through Activation of JNK and p38 Signal Pathways in Breast Cancer Cells

(2012) Yanlin Li et al.   PLoS One

JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

(2012) A H Chaanine et al.   Cell Death & Disease

Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics

(2011) Tracey R. O’Donovan et al.   Autophagy

p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment

(2011) Xinbing Sui et al.   Autophagy

HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cells

(2011) Mingyi Zhao et al.   BMB Reports

The combination of 5-Fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells

(2011) Catherine Huang et al.   CANCER BIOLOGY & THERAPY

The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival

(2011) Matthias Fuest et al.   HEPATOLOGY

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

(2011) Ting Sun et al.   Journal of Translational Medicine

Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines

(2011) Andrea Sau et al.   Molecular BioSystems

P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance

(2011) M A de la Cruz-Morcillo et al.   ONCOGENE

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

(2010) Jie Li et al.   EUROPEAN JOURNAL OF CANCER

Aberrant epigenetic patterns in the etiology of gastrointestinal cancers

(2010) Paweł Karpiński et al.   JOURNAL OF APPLIED GENETICS

Autophagy: Not good OR bad, but good AND bad

(2009) Brian J. Altman et al.   Autophagy

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Autophagy in tumour suppression and promotion

(2009) Andreas Brech et al.   Molecular Oncology

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE