The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
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Title
The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-05-20
DOI
10.3389/fcell.2020.00354
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Note: Only part of the references are listed.- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
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- (2019) Arianna Calcinotto et al. PHYSIOLOGICAL REVIEWS
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- (2018) Ming Xu et al. NATURE MEDICINE
- Effects of senolytic drugs on human mesenchymal stromal cells
- (2018) Clara Grezella et al. Stem Cell Research & Therapy
- Gene expression profiling of osteoblasts subjected to dexamethasone-induced apoptosis with/without GSK3β-shRNA
- (2018) Zhigang Nie et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway
- (2018) Shuang Deng et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2017) Meghan E. McGee-Lawrence et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Relationship between osteoporosis and expression of Bcl-2 and CXCL12
- (2017) Tongtao Pang et al. Experimental and Therapeutic Medicine
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
- (2016) Yi Zhu et al. AGING CELL
- Identification of Senescent Cells in the Bone Microenvironment
- (2016) Joshua N Farr et al. JOURNAL OF BONE AND MINERAL RESEARCH
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
- (2016) Aharon Helman et al. NATURE MEDICINE
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells
- (2015) Meghan E McGee-Lawrence et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Dexamethasone Enhances Osteogenic Differentiation of Bone Marrow- and Muscle-Derived Stromal Cells and Augments Ectopic Bone Formation Induced by Bone Morphogenetic Protein-2
- (2015) Masato Yuasa et al. PLoS One
- Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia
- (2014) Aksana Kaefer et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- Bcl2 Deficiency Activates FoxO through Akt Inactivation and Accelerates Osteoblast Differentiation
- (2014) Takeshi Moriishi et al. PLoS One
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- Effects of dexamethasone, ascorbic acid and ?-glycerophosphate on the osteogenic differentiation of stem cells in vitro
- (2013) Fabian Langenbach et al. Stem Cell Research & Therapy
- Histone deacetylase 3 is required for maintenance of bone mass during aging
- (2012) Meghan E. McGee-Lawrence et al. BONE
- Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
- (2012) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
- (2012) David W Dempster et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis
- (2011) Takeshi Moriishi et al. PLoS One
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
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