Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

Adipogenic RNAs are transferred in osteoblasts via bone marrow adipocytes-derived extracellular vesicles (EVs)

(2015) Perrine J Martin et al.   BMC CELL BIOLOGY

Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast

(2015) Julie L. Frey et al.   MOLECULAR AND CELLULAR BIOLOGY

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction

(2015) Meghan E. McGee-Lawrence et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Marrow fat composition in anorexia nervosa

(2014) Miriam A. Bredella et al.   BONE

Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise

(2014) Maya Styner et al.   BONE

A novel PPARγ2 modulator sLZIP controls the balance between adipogenesis and osteogenesis during mesenchymal stem cell differentiation

(2014) J Kim et al.   CELL DEATH AND DIFFERENTIATION

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Histone Deacetylase 7 (Hdac7) Suppresses Chondrocyte Proliferation and β-Catenin Activity during Endochondral Ossification

(2014) Elizabeth W. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones

(2014) Noriaki Ono et al.   NATURE CELL BIOLOGY

Osx-Cre Targets Multiple Cell Types besides Osteoblast Lineage in Postnatal Mice

(2014) Jianquan Chen et al.   PLoS One

TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells

(2013) Shoichiro Kokabu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of age on bone mRNA levels of sclerostin and other genes relevant to bone metabolism in humans

(2013) Matthew M. Roforth et al.   BONE

Adipocytes and the Regulation of Bone Remodeling: A Balancing Act

(2013) Mark E. Nuttall et al.   CALCIFIED TISSUE INTERNATIONAL

Histone Deacetylase 3 Suppression Increases PH Domain and Leucine-rich Repeat Phosphatase (Phlpp)1 Expression in Chondrocytes to Suppress Akt Signaling and Matrix Secretion

(2013) Elizabeth W. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the Relationship Between Bone Marrow Adipose Tissue and Volumetric Bone Mineral Density in Children and Adults

(2013) Wei Shen et al.   JOURNAL OF CLINICAL DENSITOMETRY

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic Polymorphisms in 11β-Hydroxysteroid Dehydrogenase Type 1 Correlate With the Postdexamethasone Cortisol Levels and Bone Mineral Density in Patients Evaluated for Osteoporosis

(2013) Heide Siggelkow et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Osterix-Cre Labeled Progenitor Cells Contribute to the Formation and Maintenance of the Bone Marrow Stroma

(2013) Yaling Liu et al.   PLoS One

Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation

(2013) J Li et al.   Cell Death & Disease

Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality

(2012) Natasha Case et al.   BONE

Histone deacetylase 3 is required for maintenance of bone mass during aging

(2012) Meghan E. McGee-Lawrence et al.   BONE

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Hdac-Mediated Control of Endochondral and Intramembranous Ossification

(2012) Jennifer J. Westendorf et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Pioglitazone increases bone marrow fat in type 2 diabetes: results from a randomized controlled trial

(2012) Andrew Grey et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

(2012) Lige Song et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Monodansylpentane as a Blue-Fluorescent Lipid-Droplet Marker for Multi-Color Live-Cell Imaging

(2012) Huei-Jiun Yang et al.   PLoS One

The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic women

(2012) Karolina Feldman et al.   STEROIDS

Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts

(2011) Meghan E. McGee-Lawrence et al.   BONE

Short-term physical activity intervention decreases femoral bone marrow adipose tissue in young children: A pilot study

(2011) K. Casazza et al.   BONE

Marrow fat metabolism is linked to the systemic energy metabolism

(2011) Beata Lecka-Czernik   BONE

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Diet-induced Lethality Due to Deletion of theHdac3Gene in Heart and Skeletal Muscle

(2011) Zheng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid-Induced Bone Disease

(2011) Robert S. Weinstein   NEW ENGLAND JOURNAL OF MEDICINE

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes

(2010) Aline Clabaut et al.   DIFFERENTIATION

Altered Metabolism and Lipodystrophy in the Early B-Cell Factor 1-Deficient Mouse

(2010) Jackie A. Fretz et al.   ENDOCRINOLOGY

Redundant Control of Adipogenesis by Histone Deacetylases 1 and 2

(2010) Michael Haberland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Finger Protein 467 Is a Novel Regulator of Osteoblast and Adipocyte Commitment

(2010) Julie M. Quach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage

(2010) Chikara Ushiku et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The 83,557insA variant of the gene coding 11β-hydroxysteroid dehydrogenase type 1 enzyme associates with serum osteocalcin in patients with endogenous Cushing's syndrome

(2010) Ágnes Szappanos et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Histone Deacetylase 3 Depletion in Osteo/Chondroprogenitor Cells Decreases Bone Density and Increases Marrow Fat

(2010) David F. Razidlo et al.   PLoS One

The 11 -hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone

(2010) K. Raza et al.   RHEUMATOLOGY

Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice

(2009) Robert S. Weinstein et al.   AGING CELL

HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia

(2009) Joo-Yeon Hwang et al.   BONE

Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro

(2009) Alexandre Elbaz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Aging Mice Show a Decreasing Correlation of Gene Expression within Genetic Modules

(2009) Lucinda K. Southworth et al.   PLoS Genetics

Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells

(2008) Carl-Magnus Bäckesjö et al.   CELLS TISSUES ORGANS

Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

(2008) Sarah K Knutson et al.   EMBO JOURNAL

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

(2008) Theresa Alenghat et al.   NATURE

Activation of Hedgehog Signaling Inhibits Osteoblast Differentiation of Human Mesenchymal Stem Cells

(2008) Magali Plaisant et al.   STEM CELLS

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR