Characterization of a novel type III CRISPR-Cas effector provides new insights into the allosteric activation and suppression of the Cas10 DNase

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Genetic Dissection of the Type III-A CRISPR-Cas System Csm Complex Reveals Roles of Individual Subunits

(2019) Irmantas Mogila et al.   Cell Reports

Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry

(2019) Minghui Guo et al.   CELL RESEARCH

A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system

(2019) Saifu Pan et al.   RNA Biology

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity

(2019) Ning Jia et al.   MOLECULAR CELL

Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path

(2019) Ning Jia et al.   MOLECULAR CELL

Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system

(2019) Tong Guo et al.   RNA Biology

Three New Cs for CRISPR: Collateral, Communicate, Cooperate

(2019) Andrew Varble et al.   TRENDS IN GENETICS

Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

(2019) Rafael Molina et al.   Nature Communications

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

The ribonuclease activity of Csm6 is required for anti-plasmid immunity by Type III-A CRISPR-Cas systems

(2018) Kawanda Foster et al.   RNA Biology

Control of cyclic oligoadenylate synthesis in a type III CRISPR system

(2018) Christophe Rouillon et al.   eLife

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

(2018) Januka S. Athukoralage et al.   NATURE

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

(2018) Lilan You et al.   CELL

Cryo-EM structure of Type III-A CRISPR effector complex

(2018) Yangao Huo et al.   CELL RESEARCH

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity

(2018) Ning Jia et al.   MOLECULAR CELL

Dynamics of Cas10 Govern Discrimination between Self and Non-self in Type III CRISPR-Cas Immunity

(2018) Ling Wang et al.   MOLECULAR CELL

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA

(2017) Yingjun Li et al.   NUCLEIC ACIDS RESEARCH

Nonsense-mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology

(2017) Xin Han et al.   NUCLEIC ACIDS RESEARCH

Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail

(2017) Wenyuan Han et al.   NUCLEIC ACIDS RESEARCH

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Type III CRISPR-Cas Immunity: Major Differences Brushed Aside

(2017) Gintautas Tamulaitis et al.   TRENDS IN MICROBIOLOGY

RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System

(2017) Tina Y. Liu et al.   PLoS One

Programmable type III-A CRISPR-Cas DNA targeting modules

(2017) H. Travis Ichikawa et al.   PLoS One

Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity

(2016) Wenyan Jiang et al.   CELL

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex

(2016) Michael A. Estrella et al.   GENES & DEVELOPMENT

Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system

(2016) Joshua R. Elmore et al.   GENES & DEVELOPMENT

Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition

(2016) Migle Kazlauskiene et al.   MOLECULAR CELL

Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

(2016) Prarthana Mohanraju et al.   SCIENCE

Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

(2015) Poulami Samai et al.   CELL

Crystal Structure of the CRISPR-Cas RNA Silencing Cmr Complex Bound to a Target Analog

(2015) Takuo Osawa et al.   MOLECULAR CELL

CRISPR-Cas immunity in prokaryotes

(2015) Luciano A. Marraffini   NATURE

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

(2015) D. W. Taylor et al.   SCIENCE

Characterization of pMC11, a plasmid with dual origins of replication isolated from Lactobacillus casei MCJ and construction of shuttle vectors with each replicon

(2014) Zhengjun Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex

(2014) Caryn R. Hale et al.   GENES & DEVELOPMENT

RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

(2014) Raymond H.J. Staals et al.   MOLECULAR CELL

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

(2014) Gregory W. Goldberg et al.   NATURE

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus

(2014) Ziga Zebec et al.   NUCLEIC ACIDS RESEARCH

An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference

(2014) Wenfang Peng et al.   NUCLEIC ACIDS RESEARCH

Genetic Characterization of Antiplasmid Immunity through a Type III-A CRISPR-Cas System

(2013) A. Hatoum-Aslan et al.   JOURNAL OF BACTERIOLOGY

A Ruler Protein in a Complex for Antiviral Defense Determines the Length of Small Interfering CRISPR RNAs

(2013) Asma Hatoum-Aslan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus

(2013) Raymond H.J. Staals et al.   MOLECULAR CELL

Structure of the CRISPR Interference Complex CSM Reveals Key Similarities with Cascade

(2013) Christophe Rouillon et al.   MOLECULAR CELL

A novel interference mechanism by a type IIIB CRISPR-Cmr module inSulfolobus

(2013) Ling Deng et al.   MOLECULAR MICROBIOLOGY

Unexpectedly broad target recognition of the CRISPR-mediated virus defence system in the archaeon Sulfolobus solfataricus

(2013) Andrea Manica et al.   NUCLEIC ACIDS RESEARCH

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

(2012) Jing Zhang et al.   MOLECULAR CELL

Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs

(2012) Caryn R. Hale et al.   MOLECULAR CELL

Modulation of CRISPR locus transcription by the repeat-binding protein Cbp1 in Sulfolobus

(2011) Ling Deng et al.   NUCLEIC ACIDS RESEARCH

Self versus non-self discrimination during CRISPR RNA-directed immunity

(2010) Luciano A. Marraffini et al.   NATURE

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

(2009) Caryn R. Hale et al.   CELL

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

(2008) Luciano A. Marraffini et al.   SCIENCE