Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Pathogenic Mechanisms Associated With Different Clinical Courses of Multiple Sclerosis

(2019) Hans Lassmann   Frontiers in Immunology

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis

(2018) Sabina Luchetti et al.   ACTA NEUROPATHOLOGICA

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells

(2018) Joana Machado-Santos et al.   BRAIN

Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis

(2018) T. Zeis et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation

(2018) Eman M. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Unique TGFB1-Driven Genomic Program Links Astrocytosis, Low-Grade Inflammation and Partial Demyelination in Spinal Cord Periplaques from Progressive Multiple Sclerosis Patients

(2017) Serge Nataf et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

(2017) Franc Llorens et al.   Molecular Neurodegeneration

Defining active progressive multiple sclerosis

(2017) Finn Sellebjerg et al.   Multiple Sclerosis Journal

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Dipeptidyl Peptidase‐4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation

(2017) Taichi Ikedo et al.   Journal of the American Heart Association

Defining active progressive multiple sclerosis

(2017) Finn Sellebjerg et al.   Multiple Sclerosis Journal

In Silico Prediction Analysis of Idiotope-Driven T–B Cell Collaboration in Multiple Sclerosis

(2017) Rune A. Høglund et al.   Frontiers in Immunology

The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain

(2016) Lukas Haider et al.   BRAIN

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease

(2016) Rina Zilkha-Falb et al.   Journal of Neuroinflammation

Vascular comorbidities in multiple sclerosis: a nationwide study from Denmark

(2016) Anja Thormann et al.   JOURNAL OF NEUROLOGY

Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma

(2016) Xing-gang Mao et al.   Oncotarget

Disease Type- and Status-Specific Alteration of CSF Metabolome Coordinated with Clinical Parameters in Inflammatory Demyelinating Diseases of CNS

(2016) Soo Jin Park et al.   PLoS One

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

Intrathecal BCR transcriptome in multiple sclerosis versus other neuroinflammation: Equally diverse and compartmentalized, but more mutated, biased and overlapping with the proteome

(2015) Jorunn N. Johansen et al.   CLINICAL IMMUNOLOGY

DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model

(2015) N. Kurabayashi et al.   EMBO REPORTS

Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

(2015) Diana Aguirre-Rueda et al.   International Journal of Medical Sciences

RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression

(2015) Reetika Bhardwaj et al.   JOURNAL OF IMMUNOLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

(2015) G Hinsinger et al.   Multiple Sclerosis Journal

Integrated interactions database: tissue-specific view of the human and model organism interactomes

(2015) Max Kotlyar et al.   NUCLEIC ACIDS RESEARCH

Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis

(2015) G Hinsinger et al.   Multiple Sclerosis Journal

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

KeyPathwayMiner 4.0: condition-specific pathway analysis by combining multiple omics studies and networks with Cytoscape

(2014) Nicolas Alcaraz et al.   BMC Systems Biology

Relapsing and progressive forms of multiple sclerosis

(2014) Ranjan Dutta et al.   CURRENT OPINION IN NEUROLOGY

Role for mammalian chitinase 3-like protein 1 in traumatic brain injury

(2014) Clayton A. Wiley et al.   NEUROPATHOLOGY

Pharmacologic stabilization of hypoxia-inducible transcription factors protects developing mouse brain from hypoxia-induced apoptotic cell death

(2014) R. Trollmann et al.   NEUROSCIENCE

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

(2014) J. N. H. Stern et al.   Science Translational Medicine

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

Multiple sclerosis: Lessons from molecular neuropathology

(2013) Hans Lassmann   EXPERIMENTAL NEUROLOGY

Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains

(2013) Jimmy L Huynh et al.   NATURE NEUROSCIENCE

Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury

(2013) K. Kanemaru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The Neuroprotective Functions of Transforming Growth Factor Beta Proteins

(2012) Arpád Dobolyi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice

(2012) May H. Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The emerging role of the mitochondrial-derived peptide humanin in stress resistance

(2012) Kelvin Yen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

NGS QC Toolkit: A Toolkit for Quality Control of Next Generation Sequencing Data

(2012) Ravi K. Patel et al.   PLoS One

The neuropathological basis of clinical progression in multiple sclerosis

(2011) Richard Reynolds et al.   ACTA NEUROPATHOLOGICA

Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis

(2011) Laura Lovato et al.   BRAIN

Astrocyte and Macrophage Regulation of YKL-40 Expression and Cellular Response in Neuroinflammation

(2011) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis

(2010) Roberta Magliozzi et al.   ANNALS OF NEUROLOGY

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death

(2010) S. Veto et al.   BRAIN

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Immunoglobulins and complement in postmortem multiple sclerosis tissue

(2009) Michael H. Barnett et al.   ANNALS OF NEUROLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress

(2009) Adil Anwar et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

(2009) Bruce D Trapp et al.   LANCET NEUROLOGY

Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach

(2008) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Mitochondrial defects in acute multiple sclerosis lesions

(2008) Don Mahad et al.   BRAIN

MHC class II exacerbates demyelination in vivo independently of T cells

(2008) Meenaxi M. Hiremath et al.   JOURNAL OF NEUROIMMUNOLOGY

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis

(2008) Birgit Obermeier et al.   NATURE MEDICINE

Review: Mitochondria and disease progression in multiple sclerosis

(2008) D. Mahad et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY