IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells

Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer

(2020) Mei-Ren Pan et al.   Cancers

Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK–YAP signaling axis

(2020) Yusuke Goto et al.   ONCOGENE

Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

(2019) Minhong Shen et al.   CANCER CELL

Insights into Molecular Classifications of Triple-Negative Breast Cancer: Improving Patient Selection for Treatment

(2019) Ana C. Garrido-Castro et al.   Cancer Discovery

Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells

(2019) Damiano Cosimo Rigiracciolo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

GPCR-Hippo Signaling in Cancer

(2019) Luo et al.   Cells

Role of the Hippo Pathway in Fibrosis and Cancer

(2019) Kim et al.   Cells

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

(2019) Pirashaanthy Tharmapalan et al.   EMBO JOURNAL

Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways

(2019) Haim Werner et al.   Cells

Regulation of TEAD Transcription Factors in Cancer Biology

(2019) Hyunbin D. Huh et al.   Cells

Therapeutic Targeting of the IGF Axis

(2019) Eliot Osher et al.   Cells

Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge

(2019) Nedeljković et al.   Cells

Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

(2019) Jacopo Gavini et al.   Cell Death & Disease

Below the Surface: IGF-1R Therapeutic Targeting and Its Endocytic Journey

(2019) Caitrin Crudden et al.   Cells

Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells

(2019) Rive Sarfstein et al.   Cells

Multikinase Inhibitor CT-707 Targets Liver Cancer by Interrupting the Hypoxia-Activated IGF-1R–YAP Axis

(2018) Hong Zhu et al.   CANCER RESEARCH

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

IGF1 receptor signaling pathways

(2018) Fumihiko Hakuno et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways

(2018) Yulei Zhao et al.   MOLECULAR CANCER RESEARCH

Identification of potential core genes in triple negative breast cancer using bioinformatics analysis

(2018) Man-Xiu Li et al.   OncoTargets and Therapy

VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

(2018) Ning Ji et al.   Frontiers in Pharmacology

Targeting the Hippo Pathway for Breast Cancer Therapy

(2018) Liqing Wu et al.   Cancers

Prognostic value of vitamin D receptor and insulin-like growth factor receptor 1 expression in triple-negative breast cancer

(2017) Martina Soljic et al.   JOURNAL OF CLINICAL PATHOLOGY

Glucocorticoid receptor signalling activates YAP in breast cancer

(2017) Giovanni Sorrentino et al.   Nature Communications

YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways

(2017) Daniel Andrade et al.   Oncotarget

KEGG: new perspectives on genomes, pathways, diseases and drugs

(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Estrogen regulates Hippo signaling via GPER in breast cancer

(2015) Xin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

FAK signaling in human cancer as a target for therapeutics

(2015) Brian Y. Lee et al.   PHARMACOLOGY & THERAPEUTICS

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

(2015) LaTonia Taliaferro-Smith et al.   Oncotarget

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

Emerging Roles of Focal Adhesion Kinase in Cancer

(2015) Yu-Ling Tai et al.   Biomed Research International

Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation

(2015) Susan M. Farabaugh et al.   Frontiers in Endocrinology

Oncotargeting G proteins: The Hippo in the room

(2015) Xiaodong Feng et al.   Oncotarget

Insulin-like Growth Factor-Dependent Proliferation and Survival of Triple-Negative Breast Cancer Cells: Implications for Therapy

(2015) Zoë Davison et al.   NEOPLASIA

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance

(2014) Hui Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

(2013) R. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells

(2012) R. Lappano et al.   CURRENT CANCER DRUG TARGETS

Involvement of the Src-cortactin pathway in migration induced by IGF-1 and EGF in human breast cancer cells

(2012) SILVIA MEZI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting Insulin and Insulin-Like Growth Factor Signaling in Breast Cancer

(2012) Yuzhe Yang et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes

(2011) Rinat Yerushalmi et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining the pathway to insulin-like growth factor system targeting in cancer

(2010) Steven A. Rosenzweig et al.   BIOCHEMICAL PHARMACOLOGY

Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma

(2010) Hermien Hartog et al.   BREAST CANCER RESEARCH AND TREATMENT

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

(2010) B. C. Litzenburger et al.   CLINICAL CANCER RESEARCH

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

(2010)   LANCET ONCOLOGY

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

(2010) E. Buck et al.   MOLECULAR CANCER THERAPEUTICS

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

(2009) Sandra Andersson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

(2009) Deo Prakash Pandey et al.   EMBO JOURNAL

GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information

(2009) R. Nogales-Cadenas et al.   NUCLEIC ACIDS RESEARCH

Phosphorylated Insulin-Like Growth Factor-I/Insulin Receptor Is Present in All Breast Cancer Subtypes and Is Related to Poor Survival

(2008) J. H. Law et al.   CANCER RESEARCH

Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo

(2008) N. Watanabe et al.   CLINICAL CANCER RESEARCH

Insulin-Like Growth Factor-I Activates Gene Transcription Programs Strongly Associated With Poor Breast Cancer Prognosis

(2008) Chad J. Creighton et al.   JOURNAL OF CLINICAL ONCOLOGY