Emerging Roles of Focal Adhesion Kinase in Cancer

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment

(2015) Po-Chun Chen et al.   Oncotarget

MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells

(2014) Vita Golubovskaya et al.   Anti-Cancer Agents in Medicinal Chemistry

Plasminogen activator inhibitor-1 regulates infiltration of macrophages into melanoma via phosphorylation of FAK-Tyr925

(2014) Bikash Thapa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation

(2014) M H A M van Miltenburg et al.   BRITISH JOURNAL OF CANCER

Focal adhesion kinase (FAK) siRNA inhibits human hypertrophic scar by suppressing integrin α, TGF-β and α-SMA

(2014) Rui Chen et al.   CELL BIOLOGY INTERNATIONAL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Interactions of the Protein-tyrosine Phosphatase-α with the Focal Adhesion Targeting Domain of Focal Adhesion Kinase Are Involved in Interleukin-1 Signaling in Fibroblasts

(2014) Qin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway

(2014) Rong-kun Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression

(2014) Janna K Mouw et al.   NATURE MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

(2014) Y. H. Bae et al.   Science Signaling

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

A Small-molecule Inhibitor, 5'-O-Tritylthymidine, Targets FAK and Mdm-2 Interaction, and Blocks Breast and Colon Tumorigenesis in vivo

(2013) Vita M. Golubovskaya et al.   Anti-Cancer Agents in Medicinal Chemistry

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

(2013) Vita M Golubovskaya et al.   BMC CANCER

RNA interference targeting human FAK and EGFR suppresses human non-small-cell lung cancer xenograft growth in nude mice

(2013) C Li et al.   CANCER GENE THERAPY

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

(2013) M. Luo et al.   CANCER RESEARCH

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Off-targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies usingFak-deficient mice

(2013) M. E. Roh et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

(2013) H. E. Barker et al.   MOLECULAR CANCER RESEARCH

Dual role of immunomodulation by anticancer chemotherapy

(2013) Michael R Shurin   NATURE MEDICINE

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

(2012) Deniz A. Ucar et al.   CELL CYCLE

Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activitiesin Vivo

(2012) Huaping Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

(2012) Iris Eke et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

(2012) Jeffrey R. Infante et al.   JOURNAL OF CLINICAL ONCOLOGY

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma

(2012) Naito Kurio et al.   ORAL ONCOLOGY

MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression

(2012) Xiangjun Kong et al.   PLoS One

Evolving Therapies and FAK Inhibitors for the Treatment of Cancer

(2011) Kelli Bullard Dunn et al.   Anti-Cancer Agents in Medicinal Chemistry

Interaction of tumor cells with the microenvironment

(2011) Hendrik Ungefroren et al.   Cell Communication and Signaling

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

(2011) Steven N. Hochwald et al.   CELL CYCLE

Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo

(2011) Naito Kurio et al.   EXPERIMENTAL CELL RESEARCH

Compensatory Function of Pyk2 Protein in the Promotion of Focal Adhesion Kinase (FAK)-null Mammary Cancer Stem Cell Tumorigenicity and Metastatic Activity

(2011) Huaping Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

(2011) J. B. Stokes et al.   MOLECULAR CANCER THERAPEUTICS

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-  and integrin/focal adhesion kinase (FAK) signaling

(2011) M. Schober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement

(2011) Alan Serrels et al.   Cell Adhesion & Migration

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

(2010) Isabelle Tanjoni et al.   CANCER BIOLOGY & THERAPY

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

(2010) Colin Walsh et al.   CANCER BIOLOGY & THERAPY

Endothelial FAK is required for tumour angiogenesis

(2010) Bernardo Tavora et al.   EMBO Molecular Medicine

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer

(2010) Hongbing Jiang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Macrophage motility requires distinct α5β1/FAK and α4β1/paxillin signaling events

(2010) Michelle Y. Abshire et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA

(2010) Jie Ding et al.   NATURE CELL BIOLOGY

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

Signal transduction by focal adhesion kinase in cancer

(2009) Jihe Zhao et al.   CANCER AND METASTASIS REVIEWS

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

(2009) M. Luo et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

FAK overexpression and p53 mutations are highly correlated in human breast cancer

(2009) Vita M. Golubovskaya et al.   INTERNATIONAL JOURNAL OF CANCER

Tyrosine Phosphorylation of Growth Factor Receptor-bound Protein-7 by Focal Adhesion Kinase in the Regulation of Cell Migration, Proliferation, and Tumorigenesis

(2009) Pei-Yu Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia - differential roles for paxillin and p130Cas

(2009) N. K. Zouq et al.   JOURNAL OF CELL SCIENCE

Small Molecule Chloropyramine Hydrochloride (C4) Targets the Binding Site of Focal Adhesion Kinase and Vascular Endothelial Growth Factor Receptor 3 and Suppresses Breast Cancer Growth in Vivo

(2009) Elena V. Kurenova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrin  1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

(2009) T. Shibue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells

(2008) Jie Zhu et al.   EXPERIMENTAL EYE RESEARCH

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

(2007) Carla Cicchini et al.   EXPERIMENTAL CELL RESEARCH

TAE226-Induced apoptosis in breast cancer cells with overexpressed Src or EGFR

(2007) Vita M. Golubovskaya et al.   MOLECULAR CARCINOGENESIS

p53 regulates FAK expression in human tumor cells

(2007) Vita M. Golubovskaya et al.   MOLECULAR CARCINOGENESIS