Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
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Title
Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
Authors
Keywords
TNBC, MDA-MB 231, SUM159, GPER, G-15, FAK, VS-4718, STAT3, STA21
Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 38, Issue 1, Pages -
Publisher
Springer Nature
Online
2019-02-06
DOI
10.1186/s13046-019-1056-8
References
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Note: Only part of the references are listed.- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
- (2018) Ruixia Huang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer
- (2018) Huiling Lai et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
- (2018) Yuan-Yuan Qiang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma
- (2018) Dongliang Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion
- (2018) Caiyun Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling
- (2018) Jing Luo et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs)
- (2018) Rosamaria Lappano et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Recent Advances in the Treatment of Breast Cancer
- (2018) Christy W. S. Tong et al. Frontiers in Oncology
- Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer
- (2018) Jie Shen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Classification of triple-negative breast cancers based on Immunogenomic profiling
- (2018) Yin He et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer
- (2017) Francesca Cirillo et al. Oncotarget
- Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3
- (2016) Nishant P. Visavadiya et al. Cell Communication and Signaling
- GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response
- (2016) Paola De Marco et al. Scientific Reports
- Targeting FAK scaffold functions inhibits human renal cell carcinoma growth
- (2015) Claire Béraud et al. INTERNATIONAL JOURNAL OF CANCER
- FAK signaling in human cancer as a target for therapeutics
- (2015) Brian Y. Lee et al. PHARMACOLOGY & THERAPEUTICS
- GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells
- (2015) Damiano Cosimo Rigiracciolo et al. Oncotarget
- FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells
- (2015) LaTonia Taliaferro-Smith et al. Oncotarget
- Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration
- (2015) Jui-Chung Wu et al. Scientific Reports
- Estrogens Induce Rapid Cytoskeleton Re-Organization in Human Dermal Fibroblasts via the Non-Classical Receptor GPR30
- (2015) Julie Carnesecchi et al. PLoS One
- High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype
- (2014) Vita M Golubovskaya et al. BMC CANCER
- Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
- (2014) Christine Jean et al. JOURNAL OF CELL BIOLOGY
- Understanding the Roles of FAK in Cancer
- (2014) Hyunho Yoon et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- STAT3 Target Genes Relevant to Human Cancers
- (2014) Richard Carpenter et al. Cancers
- GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)
- (2013) Marco Pupo et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- GPER Mediates Cardiotropic Effects in Spontaneously Hypertensive Rat Hearts
- (2013) Ernestina Marianna De Francesco et al. PLoS One
- Estradiol and Tamoxifen Induce Cell Migration through GPR30 and Activation of Focal Adhesion Kinase (FAK) in Endometrial Cancers with Low or without Nuclear Estrogen Receptor α (ERα)
- (2013) Chia-Lung Tsai et al. PLoS One
- Two Novel GPER Agonists Induce Gene Expression Changes and Growth Effects in Cancer Cells
- (2012) R. Lappano et al. CURRENT CANCER DRUG TARGETS
- Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activitiesin Vivo
- (2012) Huaping Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Focal Adhesion Kinase as a Cancer Therapy Target
- (2011) Vita M. Golubovskaya Anti-Cancer Agents in Medicinal Chemistry
- GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells
- (2011) Adele Vivacqua et al. BREAST CANCER RESEARCH AND TREATMENT
- Heterogeneity in breast cancer
- (2011) Kornelia Polyak JOURNAL OF CLINICAL INVESTIGATION
- The G-protein-coupled estrogen receptor GPER in health and disease
- (2011) Eric R. Prossnitz et al. Nature Reviews Endocrinology
- Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein
- (2011) Olav A Gressner WORLD JOURNAL OF GASTROENTEROLOGY
- Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
- (2010) Xiaofeng Zhao et al. ADVANCED DRUG DELIVERY REVIEWS
- Clinical significance of high focal adhesion kinase gene copy number and overexpression in invasive breast cancer
- (2010) Cha Kyong Yom et al. BREAST CANCER RESEARCH AND TREATMENT
- Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models
- (2010) Colin Walsh et al. CANCER BIOLOGY & THERAPY
- Nuclear Alternate Estrogen Receptor GPR30 Mediates 17 -Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts
- (2010) A. Madeo et al. CANCER RESEARCH
- Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten
- (2010) I. Barbieri et al. CANCER RESEARCH
- Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation
- (2010) Ssang-Taek Lim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
- (2010) Chen Huang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Estrogen receptor- promotes endothelial cell motility through focal adhesion kinase
- (2010) A. M. Sanchez et al. MOLECULAR HUMAN REPRODUCTION
- G protein-coupled receptors: novel targets for drug discovery in cancer
- (2010) Rosamaria Lappano et al. NATURE REVIEWS DRUG DISCOVERY
- Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis
- (2009) Ming Luo et al. CANCER LETTERS
- Cell migration to the chemokine CXCL8: Paxillin is activated and regulates adhesion and cell motility
- (2009) E. Cohen-Hillel et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF
- (2009) Deo Prakash Pandey et al. EMBO JOURNAL
- The unfolding stories of GPR30, a new membrane-bound estrogen receptor
- (2009) Marcello Maggiolini et al. JOURNAL OF ENDOCRINOLOGY
- Focal adhesion mediated intracellular signaling, Stat3 translocation and osteoblast differentiation: regulation by substratum topography
- (2009) D. W. Hamilton et al. MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK
- Mechanisms of estrogen signaling and gene expression via GPR30
- (2009) Eric R. Prossnitz et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer
- (2008) Paolo P. Provenzano et al. AMERICAN JOURNAL OF PATHOLOGY
- Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
- (2008) Eric R. Prossnitz et al. Annual Review of Physiology
- Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells
- (2008) Napoleon Navarro-Tito et al. EXPERIMENTAL CELL RESEARCH
- A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling
- (2008) Rajinder S. Sawhney et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation
- (2008) Ssang-Taek Lim et al. MOLECULAR CELL
- Extra-Nuclear Signalling of Estrogen Receptor to Breast Cancer Cytoskeletal Remodelling, Migration and Invasion
- (2008) Maria Silvia Giretti et al. PLoS One
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