Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

Potentiation of cannabinoid signaling in microglia by adenosine A 2A receptor antagonists

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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

(2019) Kevin Carvalho et al.   BRAIN

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

(2019) Francisco Q. Gonçalves et al.   NEUROBIOLOGY OF DISEASE

N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease

(2018) Erin J. Kodis et al.   Alzheimers & Dementia

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB 1 and CB 2 receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

(2018) Gemma Navarro et al.   BRAIN BEHAVIOR AND IMMUNITY

Propofol attenuates BV2 microglia inflammation via NMDA receptor inhibition

(2018) Qichao Wu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors

(2018) Mariana Temido-Ferreira et al.   MOLECULAR PSYCHIATRY

Blockade of adenosine A 2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

(2018) António C. Silva et al.   NEUROBIOLOGY OF DISEASE

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2018) Emilie Faivre et al.   Frontiers in Molecular Neuroscience

Adenosine A2A Receptors Facilitate Synaptic NMDA Currents in CA1 Pyramidal Neurons

(2018) Francisco Mouro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease

(2018) Cristina Gussago et al.   JOURNAL OF ALZHEIMERS DISEASE

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

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Caffeine as a Protective Factor in Dementia and Alzheimer's Disease

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia

(2016) S. Wendt et al.   JOURNAL OF NEUROSCIENCE

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors

(2016) Silvia Viana da Silva et al.   Nature Communications

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

(2016) Rafael Franco et al.   Frontiers in Pharmacology

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain

(2015) Leandra C. Constantino et al.   BEHAVIOURAL BRAIN RESEARCH

Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum

(2015) E. Martínez-Pinilla et al.   BIOCHEMICAL PHARMACOLOGY

2′,3′-cAMP, 3′-AMP, 2′-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors

(2015) Elizabeth A. Newell et al.   BRAIN RESEARCH

A Long-Term Study of Istradefylline Safety and Efficacy in Patients With Parkinson Disease

(2015) Tomoyoshi Kondo et al.   CLINICAL NEUROPHARMACOLOGY

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

(2014) Ana R. Santiago et al.   MEDIATORS OF INFLAMMATION

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

(2014) C Laurent et al.   MOLECULAR PSYCHIATRY

Adenosine A2Areceptor antagonist istradefylline reduces daily OFF time in Parkinson's disease

(2013) Yoshikuni Mizuno et al.   MOVEMENT DISORDERS

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

In vitro pharmacological profile of the A2A receptor antagonist istradefylline

(2013) Mayumi Saki et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Adenosine and Related Drugs in Brain Diseases: Present and Future in Clinical Trials

(2011) Luisa V. Lopes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

Adenosine A2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice

(2009) Li Gui et al.   BRAIN RESEARCH

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology