Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice

(2017) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

(2017) Gary W. Arendash et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

(2017) Rodrigo A. Cunha et al.   JOURNAL OF ALZHEIMERS DISEASE

Caffeine Exposure and the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studiess

(2017) João Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease

(2014) Stefka Gyoneva et al.   NEUROBIOLOGY OF DISEASE

A Case-Control Study of the Protective Effect of Alcohol, Coffee, and Cigarette Consumption on Parkinson Disease Risk: Time-Since-Cessation Modifies the Effect of Tobacco Smoking

(2014) Marianne van der Mark et al.   PLoS One

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons

(2013) Deepti Chugh et al.   EXPERIMENTAL NEUROLOGY

The A1 adenosine receptor as a new player in microglia physiology

(2013) L. Luongo et al.   GLIA

Potential role of A2A adenosine receptor in traumatic optic neuropathy

(2013) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

(2013) Catarina Gomes et al.   Journal of Neuroinflammation

ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy

(2013) Nehal M. Elsherbiny et al.   LIFE SCIENCES

Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease

(2013) Sandeep Vasant More et al.   MEDIATORS OF INFLAMMATION

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System

(2013) Joana Vindeirinho et al.   PLoS One

Microglia: An Active Player in the Regulation of Synaptic Activity

(2013) Kyungmin Ji et al.   NEURAL PLASTICITY

Caffeine Intake, Smoking, and Risk of Parkinson Disease in Men and Women

(2012) R. Liu et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The role of microglia in the neurogenesis of zebrafish retina

(2012) Tao Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Definition of glaucoma: clinical and experimental concepts

(2012) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Crude caffeine reduces memory impairment and amyloid β1–42 levels in an Alzheimer’s mouse model

(2012) Yi-Fang Chu et al.   FOOD CHEMISTRY

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo

(2012) Nina Swinnen et al.   GLIA

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway

(2012) Ana Patrícia Simões et al.   Journal of Neuroinflammation

Sialic Acid on the Neuronal Glycocalyx Prevents Complement C1 Binding and Complement Receptor-3-Mediated Removal by Microglia

(2012) B. Linnartz et al.   JOURNAL OF NEUROSCIENCE

Istradefylline, an adenosine A2A receptor antagonist, for patients with Parkinson's Disease: A meta-analysis

(2012) Wanqiang Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

(2012) G.N. Costa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

(2012) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Complement-Mediated Microglial Clearance of Developing Retinal Ganglion Cell Axons

(2012) Carolyn M. Tyler et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Clinical Evidence for Neuroprotection in Glaucoma

(2011) M. Francesca Cordeiro et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Microglia/Macrophages Migrate through Retinal Epithelium Barrier by a Transcellular Route in Diabetic Retinopathy

(2011) Samy Omri et al.   AMERICAN JOURNAL OF PATHOLOGY

Retinal Microglial Activation and Inflammation Induced by Amadori-Glycated Albumin in a Rat Model of Diabetes

(2011) A. S. Ibrahim et al.   DIABETES

Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson’s disease

(2011) R. A. Popat et al.   EUROPEAN JOURNAL OF NEUROLOGY

Involvement of the CD200 receptor complex in microglia activation in experimental glaucoma

(2011) Sarah Taylor et al.   EXPERIMENTAL EYE RESEARCH

Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks

(2011) C. Rigato et al.   GLIA

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction

(2011) Nelson Rebola et al.   JOURNAL OF NEUROCHEMISTRY

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity

(2011) J. T. Rogers et al.   JOURNAL OF NEUROSCIENCE

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

(2011) Andrew D. Kraft et al.   NEUROBIOLOGY OF AGING

Role of Secondary Mediators in Caffeine-Mediated Neuroprotection in Maneb- and Paraquat-Induced Parkinson’s Disease Phenotype in the Mouse

(2011) Sharawan Yadav et al.   NEUROCHEMICAL RESEARCH

HIV-1 Tat-Induced Microgliosis and Synaptic Damage via Interactions between Peripheral and Central Myeloid Cells

(2011) Shao-Ming Lu et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration

(2010) Catarina V. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

(2010) C. A. Aveleira et al.   DIABETES

Neuroprotection in glaucoma – Is there a future role?

(2010) Abeir Baltmr et al.   EXPERIMENTAL EYE RESEARCH

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Local Glutamate Level Dictates Adenosine A2A Receptor Regulation of Neuroinflammation and Traumatic Brain Injury

(2010) S. S. Dai et al.   JOURNAL OF NEUROSCIENCE

Adenosine A1 Receptor Activation as a Brake on the Microglial Response after Experimental Traumatic Brain Injury in Mice

(2010) M. Lee Haselkorn et al.   JOURNAL OF NEUROTRAUMA

Caffeine attenuates lipopolysaccharide-induced neuroinflammation

(2010) Holly M. Brothers et al.   NEUROSCIENCE LETTERS

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Adenosine A2A receptor mediates microglial process retraction

(2009) Anna G Orr et al.   NATURE NEUROSCIENCE

Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation

(2009) Ana Laura De Lella Ezcurra et al.   NEUROBIOLOGY OF DISEASE

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

Diabetes-Enhanced Tumor Necrosis Factor-α Production Promotes Apoptosis and the Loss of Retinal Microvascular Cells in Type 1 and Type 2 Models of Diabetic Retinopathy

(2008) Yugal Behl et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine A2Areceptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

(2008) Liqun Yu et al.   ANNALS OF NEUROLOGY

Microglial Activation in Human Diabetic Retinopathy

(2008) Hui-yang Zeng   ARCHIVES OF OPHTHALMOLOGY

RESEARCH ARTICLE: Up-regulation of Adenosine Receptors in the Frontal Cortex in Alzheimer's Disease

(2008) José L. Albasanz et al.   BRAIN PATHOLOGY

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease

(2008) Bruce A. Yankner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-α is an independent serum marker for proliferative retinopathy in type 1 diabetic patients

(2008) Carin Gustavsson et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection in Glaucoma: Drug-Based Approaches

(2008) WILLIAM CHEUNG et al.   OPTOMETRY AND VISION SCIENCE

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS