Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

(2016) Michelle Glass et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum

(2015) E. Martínez-Pinilla et al.   BIOCHEMICAL PHARMACOLOGY

Negative cooperativity across β1-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation

(2015) Karolina Gherbi et al.   FASEB JOURNAL

Analysis of Human Dopamine D3Receptor Quaternary Structure

(2015) Sara Marsango et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine

(2015) G. Navarro et al.   JOURNAL OF NEUROSCIENCE

Evidence against dopamine D1/D2 receptor heteromers

(2015) A L Frederick et al.   MOLECULAR PSYCHIATRY

Allosteric interactions between agonists and antagonists within the adenosine A2Areceptor-dopamine D2receptor heterotetramer

(2015) Jordi Bonaventura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

(2015) Arnau Cordomí et al.   TRENDS IN BIOCHEMICAL SCIENCES

Heteromerization of GPR55 and cannabinoid CB2receptors modulates signalling

(2014) N A Balenga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

(2014) Branden A. Smeester et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum

(2014) E. Martínez-Pinilla et al.   EXPERIMENTAL NEUROLOGY

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

(2014) Ross Corriden et al.   FASEB JOURNAL

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation

(2014) Paul Grzesik et al.   FEBS Journal

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

(2014) Dasiel Borroto-Escuela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of GPCR ligands for probing signal transduction pathways

(2014) Simone Brogi et al.   Frontiers in Pharmacology

Diversity and Bias through Receptor–Receptor Interactions in GPCR Heteroreceptor Complexes. Focus on Examples from Dopamine D2 Receptor Heteromerization

(2014) Kjell Fuxe et al.   Frontiers in Endocrinology

Class A G-Protein-Coupled Receptor (GPCR) Dimers and Bivalent Ligands

(2013) Christine Hiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

(2013) E. Akgun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

(2013) Sofia Cristóvão-Ferreira et al.   Purinergic Signalling

Structural Rearrangements of Rhodopsin Subunits in a Dimer Complex: a Molecular Dynamics Simulation Study

(2012) Arnau Cordomí et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

(2012) K. Kawahara et al.   NEUROSCIENCE

Fibroblast Growth Factor Receptor 1– 5-Hydroxytryptamine 1A Heteroreceptor Complexes and Their Enhancement of Hippocampal Plasticity

(2011) Dasiel O. Borroto-Escuela et al.   BIOLOGICAL PSYCHIATRY

Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics

(2011) Lauren T. May et al.   FASEB JOURNAL

Development of a Bivalent Dopamine D2Receptor Agonist

(2011) Julia Kühhorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent Dopamine D2Receptor Ligands: Synthesis and Binding Properties

(2011) Julia Kühhorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

(2010) Melissa L. Perreault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine D1-histamine H3Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway

(2010) Estefanía Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation

(2010) Vaneeta Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

(2010) Laura Albizu et al.   Nature Chemical Biology

Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation

(2010) A. Rivero-Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

GPCR Dimers Fall Apart

(2010) N. A. Lambert   Science Signaling

Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration

(2010) A. Gupta et al.   Science Signaling

Class A GPCR heterodimers: evidence from binding studies

(2010) Nigel J.M. Birdsall   TRENDS IN PHARMACOLOGICAL SCIENCES

Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala2-MePhe4-Glyol5]Enkephalin as Selective μ−δ Agonists

(2009) Ajay S. Yekkirala et al.   ACS Chemical Neuroscience

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist–antagonist binding modulation

(2009) Vicent Casadó et al.   BIOCHEMICAL PHARMACOLOGY

G-protein-coupled receptor heteromers or how neurons can display differently flavoured patterns in response to the same neurotransmitter

(2009) Rafael Franco   BRITISH JOURNAL OF PHARMACOLOGY

Opioid-receptor-heteromer-specific trafficking and pharmacology

(2009) Richard M van Rijn et al.   CURRENT OPINION IN PHARMACOLOGY

Adenosine A2AReceptor-Antagonist/Dopamine D2Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2Receptor Heteromers

(2009) Aroa Soriano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

GPCR homomers and heteromers: A better choice as targets for drug development than GPCR monomers?

(2009) Vicent Casadó et al.   PHARMACOLOGY & THERAPEUTICS

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS