Targeting Mononuclear Phagocyte Receptors in Cancer Immunotherapy: New Perspectives of the Triggering Receptor Expressed on Myeloid Cells (TREM-1)

Targeting hypoxia in tumor: a new promising therapeutic strategy

(2020) Maria Carla Bosco et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Toll-like Receptors from the Perspective of Cancer Treatment

(2020) Nasir Javaid et al.   Cancers

The role of the triggering receptor expressed on myeloid cells-1 (TREM-1) in non-bacterial infections

(2020) Amanda de Oliveira Matos et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Triggering receptor expressed on myeloid cells-1 (TREM-1) as a therapeutic target in infectious and noninfectious disease: a critical review

(2020) Pedro Henrique dos Santos Dantas et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

(2020) Maud Mayoux et al.   Science Translational Medicine

Macrophage polarization: reaching across the aisle?

(2019) Maria Carla Bosco   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

(2019) Branimir I. Sikic et al.   JOURNAL OF CLINICAL ONCOLOGY

Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer

(2019) Qinchuan Wu et al.   HEPATOLOGY

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation

(2019) Ana Beatriz DePaula-Silva et al.   Journal of Neuroinflammation

HIV and HCV augments inflammatory responses through increased TREM-1 expression and signaling in Kupffer and Myeloid cells

(2019) Jinhee Hyun et al.   PLoS Pathogens

Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity

(2019) Yong Sun Lee et al.   Frontiers in Immunology

Significance of TIM3 expression in cancer: From biology to the clinic

(2019) Cinzia Solinas et al.   SEMINARS IN ONCOLOGY

Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy

(2019) Qin Zeng et al.   CURRENT OPINION IN BIOTECHNOLOGY

A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition

(2018) Valerie Cuvier et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer

(2018) Linnéa La Fleur et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Macrophages as a Potential Therapeutic Intervention: Impact on Inflammatory Diseases and Cancer

(2018) Mirco Ponzoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity

(2018) Curtis J. Perry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

(2018) Sabine Hoves et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-3 Stimulation Skews M2 Macrophages to M1 Through IFN-αβ Signaling and Restricts Tumor Progression

(2018) Aurobind Vidyarthi et al.   Frontiers in Immunology

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Clinicopathological and molecular specificities of inflammatory bowel disease-related colorectal neoplastic lesions: the role of inflammation

(2018) Magali Svrcek et al.   Journal of Crohns & Colitis

Soluble Triggering Receptor Expressed on Myeloid Cells 1 in lung cancer

(2018) Andreas Kuemmel et al.   Scientific Reports

Activation of phagocytosis by immune checkpoint blockade

(2018) Chia-Wei Li et al.   Frontiers of Medicine

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

(2018) Monica Parodi et al.   Frontiers in Immunology

Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors

(2018) Raffaella Fontana et al.   OncoImmunology

Cancer immunotherapy targeting the CD47/SIRPα axis

(2017) Kipp Weiskopf   EUROPEAN JOURNAL OF CANCER

Macrophages as Key Drivers of Cancer Progression and Metastasis

(2017) Sebastian R. Nielsen et al.   MEDIATORS OF INFLAMMATION

Novel TREM-1 Inhibitors Attenuate Tumor Growth and Prolong Survival in Experimental Pancreatic Cancer

(2017) Zu T. Shen et al.   MOLECULAR PHARMACEUTICS

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

(2017) Nan Guo Ring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: a systematic review and meta-analysis

(2017) Jian Cao et al.   Oncotarget

Prognostic significance of tumor-associated macrophages in breast cancer: a meta-analysis of the literature

(2017) Xixi Zhao et al.   Oncotarget

Hypoxic Stress-Induced Tumor and Immune Plasticity, Suppression, and Impact on Tumor Heterogeneity

(2017) Stéphane Terry et al.   Frontiers in Immunology

Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

(2017) Federica Raggi et al.   Frontiers in Immunology

The Prognostic and Clinicopathological Significance of Tumor-Associated Macrophages in Patients with Gastric Cancer: A Meta-Analysis

(2017) Songcheng Yin et al.   PLoS One

Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma

(2016) Baoping Guo et al.   BMC Medicine

Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer

(2016) Maria Carla Bosco et al.   CURRENT PHARMACEUTICAL DESIGN

Hypoxia-inducible factors: a central link between inflammation and cancer

(2016) Daniel Triner et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

(2016) Sofie Wilgenhof et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of Langerhans cell functions in a hypoxic environment

(2016) Daniele Pierobon et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial

(2016) Timothy M Nywening et al.   LANCET ONCOLOGY

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment

(2016) Wei Bin Fang et al.   Oncotarget

TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer

(2016) Guangbo Zhang et al.   Oncotarget

Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR

(2016) Xiaofan Guo et al.   Oncotarget

Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis

(2016) Jiandong Mei et al.   Oncotarget

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chronic inflammation and cancer: emerging roles of triggering receptors expressed on myeloid cells

(2015) Austin Huy Nguyen et al.   Expert Review of Clinical Immunology

Evaluation of the lipopolysaccharide-induced transcription of the human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells

(2015) HIROSHI HOSODA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Immunity, inflammation, and cancer: an eternal fight between good and evil

(2015) Shabnam Shalapour et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Novel Splice Variant Isoform of TREM-1 in Human Neutrophil Granules

(2015) Sankar Baruah et al.   JOURNAL OF IMMUNOLOGY

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

(2015) Jo Marie Tran Janco et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

(2015) Christine B. Read et al.   JOURNAL OF IMMUNOLOGY

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

(2015) Marine M Leblond et al.   OncoImmunology

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

(2015) Chakrapani Tripathi et al.   Oncotarget

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling

(2015) Jun Zhang et al.   Oncotarget

TREM-1, an Inflammatory Modulator, is Expressed in Hepatocellular Carcinoma Cells and Significantly Promotes Tumor Progression

(2014) Meng Duan et al.   ANNALS OF SURGICAL ONCOLOGY

Triggering receptor expressed on myeloid cells receptor family modulators: a patent review

(2014) Christopher J Pelham et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

A novel ligand-independent peptide inhibitor of TREM-1 suppresses tumor growth in human lung cancer xenografts and prolongs survival of mice with lipopolysaccharide-induced septic shock

(2014) Alexander B. Sigalov   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of TREM-1 in response to Aspergillus fumigatus infection in corneal epithelial cells

(2014) Li-ting Hu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide

(2014) K. Dower et al.   JOURNAL OF IMMUNOLOGY

Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers

(2014) Francois Moisan et al.   Molecular Oncology

TREM-1 Is Induced in Tumor Associated Macrophages by Cyclo-Oxygenase Pathway in Human Non-Small Cell Lung Cancer

(2014) Zhihong Yuan et al.   PLoS One

TREM-1 Deficiency Can Attenuate Disease Severity without Affecting Pathogen Clearance

(2014) Benjamin Weber et al.   PLoS Pathogens

Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?

(2014) Kelsey Roe et al.   Frontiers in Microbiology

Attenuation of Responses to Endotoxin by the Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor LR12 in Nonhuman Primate

(2013) Marc Derive et al.   ANESTHESIOLOGY

A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors

(2013) Shahneen K. Sandhu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

(2013) Daniele Pierobon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes/macrophages

(2013) Tae-Hwan Kim et al.   IMMUNOLOGY LETTERS

CpG-oligodeoxynucleotide-induced TLR9 activation regulates macrophage TREM-1 expression and shedding

(2013) Yair Molad et al.   Innate Immunity

Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages

(2013) Federica Raggi et al.   Innate Immunity

TREM-1 inhibition attenuates inflammation and tumor within the colon

(2013) Jiangang Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prognostic Value and Therapeutic Potential of TREM-1 in Streptococcus pyogenes-Induced Sepsis

(2013) Sarah A. Horst et al.   Journal of Innate Immunity

TREM-1 as a Potential Therapeutic Target in Psoriasis

(2013) Luke A. Hyder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

(2013) Marc Derive et al.   SHOCK

Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection

(2013) M. J. Davis et al.   mBio

Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells

(2013) Gencheng Han et al.   Frontiers in Immunology

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

(2012) Giorgio Trinchieri   Annual Review of Immunology

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

Expression of TREM-1 in hepatic stellate cells and prognostic value in hepatitis B-related hepatocellular carcinoma

(2012) Rui Liao et al.   CANCER SCIENCE

Influence of low oxygen tensions on macrophage polarization

(2012) María M. Escribese et al.   IMMUNOBIOLOGY

Dendritic cell reprogramming by the hypoxic environment

(2012) Maria Carla Bosco et al.   IMMUNOBIOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis

(2012) M. Derive et al.   JOURNAL OF IMMUNOLOGY

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

(2012) R. J. W. Arts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation and gene expression profile of tumor-associated macrophages

(2012) Astrid Schmieder et al.   SEMINARS IN CANCER BIOLOGY

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis

(2011) Feng Wang et al.   CELLULAR IMMUNOLOGY

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

(2011) Asis Palazón et al.   CLINICAL CANCER RESEARCH

Triggering Receptor Expressed on Myeloid Cell 1

(2011) Damien Barraud et al.   CRITICAL CARE CLINICS

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) Modulates Immune Responses toAspergillus fumigatusDuring Fungal Asthma in Mice

(2011) Karen F. Buckland et al.   IMMUNOLOGICAL INVESTIGATIONS

TREM-1 Amplifies Corneal Inflammation after Pseudomonas aeruginosa Infection by Modulating Toll-Like Receptor Signaling and Th1/Th2-Type Immune Responses

(2011) Minhao Wu et al.   INFECTION AND IMMUNITY

Induction of triggering receptor expressed on myeloid cells (TREM-1) in airway epithelial cells by 1,25(OH)2 vitamin D3

(2011) Isaura Rigo et al.   Innate Immunity

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Tumor-Infiltrating Programmed Death Receptor-1+ Dendritic Cells Mediate Immune Suppression in Ovarian Cancer

(2011) J. Krempski et al.   JOURNAL OF IMMUNOLOGY

Hypoxia: a double-edged sword of immunity

(2011) Antonio Sica et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells

(2011) Hiroshi Hosoda et al.   LIFE SCIENCES

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages

(2010) Mansoor Ali Syed et al.   EXPERIMENTAL CELL RESEARCH

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Macrophage Plasticity in Experimental Atherosclerosis

(2010) Jamila Khallou-Laschet et al.   PLoS One

Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis

(2009) Yousuke Murakami et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer-Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells

(2009) U. K. Scarlett et al.   CANCER RESEARCH

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

TREM and TREM-like receptors in inflammation and disease

(2009) Jill W Ford et al.   CURRENT OPINION IN IMMUNOLOGY

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

(2009) G. Semenza   CURRENT PHARMACEUTICAL DESIGN

MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands

(2009) Heng Zheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes

(2009) Kai Zanzinger et al.   IMMUNOLOGY

Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin

(2009) Meixiang Yang et al.   IMMUNOLOGY

Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth

(2009) Albert Lin et al.   IMMUNOLOGY LETTERS

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TREM-1 Activation Alters the Dynamics of Pulmonary IRAK-M Expression In Vivo and Improves Host Defense during Pneumococcal Pneumonia

(2009) H. Lagler et al.   JOURNAL OF IMMUNOLOGY

Inhibitory receptors on myeloid cells: New targets for therapy?

(2009) Ariel Munitz   PHARMACOLOGY & THERAPEUTICS

Modulation of Angiogenic and Inflammatory Response in Glioblastoma by Hypoxia

(2009) Anastasia Murat et al.   PLoS One

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

(2009) J. Kuai et al.   RHEUMATOLOGY

The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions

(2009) Georgina J. Clark et al.   TRENDS IN IMMUNOLOGY

Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis

(2008) C E Collins et al.   ANNALS OF THE RHEUMATIC DISEASES

Dendritic cells dysfunction in tumour environment

(2008) Karim Bennaceur et al.   CANCER LETTERS

Depletion of Dendritic Cells Delays Ovarian Cancer Progression by Boosting Antitumor Immunity

(2008) E. Huarte et al.   CANCER RESEARCH

Central role of dendritic cells in the regulation and deregulation of immune responses

(2008) F. Granucci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Correlation of Serum-Soluble Triggering Receptor Expressed on Myeloid Cells-1 with Clinical Disease Activity in Inflammatory Bowel Disease

(2008) Jae Jun Park et al.   DIGESTIVE DISEASES AND SCIENCES

Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration

(2008) Maria Carla Bosco et al.   IMMUNOBIOLOGY

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

The TREM-1/DAP12 pathway

(2008) Anja S. Tessarz et al.   IMMUNOLOGY LETTERS

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

TREM-1 Expression in Tumor-associated Macrophages and Clinical Outcome in Lung Cancer

(2007) Chao-Chi Ho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark