Review
Pharmacology & Pharmacy
Xing Wang, Guobing Yin, Wei Zhang, Kunlin Song, Longbin Zhang, Zufeng Guo
Summary: PTGR1, a rate-limiting enzyme in the arachidonic acid metabolism pathway, is crucial in regulating the deactivation of eicosanoids like prostaglandins and leukotriene B4, making it a promising target for cancer therapy. Current research has focused on understanding PTGR1's role in cancer, potential inhibitors, and strategies for future research and therapeutics development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuhui Lin, Mengcheng Yao, Haiyin Wu, Feng Wu, Shiying Cao, Huanyu Ni, Jian Dong, Di Yang, Yanyu Sun, Xiaolin Kou, Jun Li, Hui Xiao, Lei Chang, Jin Wu, Yan Liu, Chunxia Luo, Dongya Zhu
Summary: The study revealed that environmental enrichment promotes stroke recovery by regulating GAT-1 to enhance network excitability. GAT-1 plays a crucial role in the network plasticity and functional recovery from stroke induced by environmental enrichment.
Article
Immunology
Yanhong Shou, Ronghui Zhu, Zhenwei Tang, Xiao-Yong Man
Summary: This study identified a glycolysis-related subpopulation of keratinocytes in psoriasis patients and developed a glycolysis signature that can be used to predict treatment effectiveness.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Xiao-ren Zhu, Shi-qing Peng, Le Wang, Xiao-yu Chen, Chun-xia Feng, Yuan-yuan Liu, Min-bin Chen
Summary: PCK1 is significantly elevated in human pancreatic cancer tissues and cells, and its silencing inhibits cell proliferation and induces apoptosis. Conversely, overexpression of PCK1 in pancreatic cancer cells accelerates cell proliferation and migration. In vivo, PCK1 silencing suppresses tumor growth and Akt-mTOR activation in xenograft tissues.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Chaimae Boulhen, Saadia Ait Ssi, Hamza Benthami, Ibtissam Razzouki, Abdelhakim Lakhdar, Mehdi Karkouri, Abdallah Badou
Summary: TMIGD2, an immuno-stimulatory receptor, is closely associated with the overall survival of glioma patients and has the potential to be a promising target for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Michelle L. Aries, Tiffany Hensley-McBain
Summary: Alzheimer's disease (AD) is the leading cause of dementia in the United States, and inflammation and neutrophils have been shown to worsen AD-associated dementia. Current research has found that neutrophils migrate towards amyloid beta plaques in the brains of AD mouse models, and transcriptomic studies have revealed upregulation of neutrophil-related genes in AD patients. Neutrophil-derived inflammation and regulation present a potential therapeutic target for AD, and further investigation into neutrophil functionality and other factors like the microbiome and APOE4 allele is needed.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuechun Zhao, Yuheng Zhang, Jiaqi Li, Ningxin Zhang, Qiubai Jin, Yuxia Qi, Ping Song
Summary: Sphingosine-1-phosphate (S1P) is a sphingolipid mediator that plays a role in various biological functions and has been found to be higher in patients with psoriasis compared to healthy individuals. The S1P-S1PR signaling system is involved in inhibiting keratinocyte proliferation, regulating lymphocyte migration, and promoting angiogenesis, which contributes to the development of psoriasis. S1P may serve as a potential target for future psoriasis treatment.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Immunology
Silvere D. Zaongo, Yanqiu Liu, Vijay Harypursat, Fangzhou Song, Huan Xia, Ping Ma, Yaokai Chen
Summary: Antiretroviral therapy (ART) is the only currently effective method to treat HIV-1 infection, but may be toxic to vital organs. Therefore, considering HIV-1 restriction factors from the innate immune system to explore novel therapeutic approaches is seen as a promising strategy by researchers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hanshu Yuan, Justin Pratte, Charles Giardina
Summary: Ferroptosis is a recently defined form of programmed cell death that is distinct due to its iron dependency and accumulation of lipid hydroperoxides. It can be regulated by various cellular variables and is potentially linked to degenerative diseases and acute injury scenarios. Additionally, ferroptosis may have significance in tumor-suppression and cancer therapy as a proposed target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yan Wang, Jianliang Wei, Peng Zhang, Xin Zhang, Yifei Wang, Wenjing Chen, Yanan Zhao, Xiangning Cui
Summary: This article provides a summary of the role and mechanisms of NRG1 in cardiovascular diseases, discusses therapeutic approaches for cardiovascular diseases, and highlights future research directions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Yihui Yang, Liwen Ren, Wan Li, Yizhi Zhang, Sen Zhang, Binbin Ge, Hong Yang, Guanhua Du, Bo Tang, Hongquan Wang, Jinhua Wang
Summary: GABA is a common inhibitory neurotransmitter in the central nervous system of vertebrates, and recent studies have shown its involvement in tumor development and immune regulation. This review summarizes the role of GABAergic signaling in tumor proliferation, metastasis, progression, stemness, and the tumor microenvironment, as well as the underlying molecular mechanisms. The therapeutic advances in targeting GABA receptors for cancer treatment, particularly immunotherapy, are also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Young Ha Ahn, Se-Chan Oh, Shengtao Zhou, Tae-Don Kim
Summary: Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme in translation and has potential pharmacological implications in diseases. Despite being primarily viewed as a Trp-producing enzyme, studies are emerging on WRS as a potential therapeutic target for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Shougang Liu, Xiuqing Yuan, Hang Su, Fanghua Liu, Zhe Zhuang, Yongfeng Chen
Summary: This study explores the potential molecular mechanisms connecting psoriasis and AD through gene expression profiling analysis. Specific transcription factors play a crucial role in inflammation and metabolic disorders. The identified transcription factor, ZNF384, is a potential therapeutic target for psoriasis and AD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medical Laboratory Technology
Kai Hou, Shuai Li, Meng Zhang, Xuping Qin
Summary: Caveolin-1 is a significant pathophysiological factor in atherosclerosis, potentially influencing autophagy activation. Understanding the exact mechanisms and roles of caveolin-1 in autophagic flux can lead to novel therapeutic approaches for atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Review
Biochemistry & Molecular Biology
Jicheng Zhang, Hanlin Yin, Qiangda Chen, Guochao Zhao, Wenhui Lou, Wenchuan Wu, Ning Pu
Summary: Basophils, previously overlooked, have been found to potentially play a role in cancer development, with their function as tumor-protecting or tumor-promoting components still being debated and possibly dependent on tumor biology and the microenvironment.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryusuke Nakamoto, Lisa C. Zaba, Jarrett Rosenberg, Sunil Arani Reddy, Tomomi Watanabe Nobashi, Guido Davidzon, Carina Mari Aparici, Judy Nguyen, Farshad Moradi, Andrei Iagaru, Benjamin Lewis Franc
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Dermatology
Jeffrey M. Cloutier, Sara C. Shalin, Matthew Lindberg, Jerad M. Gardner, Sebastian Fernandez-Pol, Lisa Zaba, Roberto Novoa, Ryanne A. Brown
JOURNAL OF CUTANEOUS PATHOLOGY
(2020)
Letter
Dermatology
K. J. Ransohoff, S. B. Pugliese, L. C. Zaba, K. E. Rieger, B. Y. Kwong
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Nolan J. Maloney, Kevin A. Nguyen, Daniel Q. Bach, Lisa C. Zaba
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
John Frew, Lauren Penzi, Mayte Suarez-Farinas, Sandra Garcet, Patrick M. Brunner, Tali Czarnowicki, Jaehwan Kim, Claire Bottomley, Robert Finney, Inna Cueto, Judilyn Fuentes-Duculan, Hanako Ohmatsu, Tim Lentini, Valerie Yanofsky, James G. Krueger, Emma Guttman-Yassky, Daniel Gareau
Summary: The study developed and validated a computer-assisted image-processing algorithm (EQscore) to reliably quantify erythema across different skin types in the dermatology clinical setting. The algorithm demonstrated high agreement with clinical scoring and superior reliability compared with clinical scoring. The EQscore is easily accessible, user-friendly, and may allow dermatologists to more readily and accurately rate the severity of dermatological conditions.
EXPERIMENTAL DERMATOLOGY
(2021)
Letter
Dermatology
M. C. G. Winge, D. J. Iberri, R. A. Novoa, B. Y. Kwong, L. C. Zaba
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Allergy
Mayte Suarez-Farinas, Maria Suprun, Paul Kearney, Robert Getts, Galina Grishina, Clive Hayward, David Luta, Alex Porter, Marc Witmer, George du Toit, Gideon Lack, Rebecca Sharon Chinthrajah, Stephen J. Galli, Kari Nadeau, Hugh A. Sampson
Summary: A novel blood test using the peanut BBEA method was developed for accurate diagnosis of peanut allergy. The validation results showed that the test had a high accuracy rate of 93% and demonstrated excellent sensitivity and specificity for peanut allergy.
Letter
Hematology
Sara Choi, Maggie Zhou, Eman Bahrani, Beth A. Martin, Kristen N. Ganjoo, Lisa C. Zaba
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Suyan Tian, Chi Wang, Mayte Suarez-Farinas
Summary: The evolution of high-throughput technology has made longitudinal gene expression experiments more affordable and common in biomedical fields. The GEE-TGDR method provides a new feature selection algorithm for longitudinal data analysis, which is expected to be widely applied in omics research.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Ruixue Hou, Lewis E. Tomalin, Mayte Suarez-Farinas
Summary: The cosinoRmixedeffects R package is developed for modeling longitudinal periodic data using mixed-effects cosinor models. The package allows for covariates and interactions with non-linear parameters MESOR, amplitude, and acrophase, and utilizes emmeans package syntax and functions for estimating marginal means and contrasts. Estimation and hypothesis testing involving non-linear circadian parameters are carried out using bootstrapping, and the package functionality is illustrated through modeling heart rate variability measurements over several months.
BMC BIOINFORMATICS
(2021)
Review
Oncology
Lucy Y. Liu, Joyce M. C. Teng, Sheri L. Spunt, Jenna L. Strelo, Bernice Y. Kwong, Lisa C. Zaba
Summary: Cutaneous adverse events (cAEs) caused by targeted anticancer treatments and immune checkpoint inhibitors are common in pediatric cancer patients. It is essential to diagnose and manage these events promptly to optimize cancer-directed therapy and enhance quality of life. This systematic review summarizes dermatologic toxicities associated with targeted anticancer treatments and immune checkpoint inhibitors.
PEDIATRIC BLOOD & CANCER
(2021)
Correction
Biochemical Research Methods
Ruixue Hou, Lewis E. Tomalin, Mayte Suarez-Farinas
BMC BIOINFORMATICS
(2022)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Oncology
Mollie F. Qian, Nicolas J. Betancourt, Alain Pineda, Nolan J. Maloney, Kevin A. Nguyen, Sunil A. Reddy, Evan T. Hall, Susan M. Swetter, Lisa C. Zaba
Summary: The implementation of immune checkpoint inhibitor therapies and targeted therapies has shown positive effects on reducing melanoma-related mortality but has also led to increased healthcare costs. This article analyzes medical claims data to examine the utilization and costs of different systemic treatments for metastatic melanoma from 2016 to 2020.
Article
Medicine, Research & Experimental
Kanika Kanchan, Stepan Grinek, Henry T. Bahnson, Ingo Ruczinski, Gautam Shankar, David Larson, George Du Toit, Kathleen C. Barnes, Hugh A. Sampson, Mayte Suarez-Farinas, Gideon Lack, Gerald T. Nepom, Karen Cerosaletti, Rasika A. Mathias
Summary: We investigated the interplay between genetics and oral peanut protein exposure in determining the immunological response to peanut. We found an association between peanut-specific IgG4 and HLA-DQA1*01:02, which was only observed in individuals with sustained oral peanut protein exposure. This association was driven by IgG4 specific for the Ara h 2 component. However, the association weakened once peanut consumption ceased.
JOURNAL OF CLINICAL INVESTIGATION
(2022)