Article
Anatomy & Morphology
Sarah K. Mierke, Kelsey L. Rapier, Anna M. Method, Brooke A. King, Paul S. Kingma
Summary: Surfactant protein D (SP-D) is a host defense protein that clears infectious pathogens from the lung. This study found that SP-D is also present in plasma and other non-pulmonary tissues. The researchers hypothesized that systemic SP-D may clear infectious pathogens and regulate host defense cells in extrapulmonary systems. Their results suggest that circulating SP-D decreases systemic inflammation and raises the possibility that its increased levels during infection serve to scavenge infectious pathogens and limit inflammation-induced tissue injury.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2023)
Article
Critical Care Medicine
John A. Kellum, Claudio Ronco
Summary: Septic shock, caused by bacterial toxins like endotoxin, is a severe disease that can lead to organ failure. It is important to note that endotoxin may play a role in all types of septic shock, including non-bacterial causes such as COVID-19. Diagnosis relies on measuring endotoxin activity in addition to clinical assessment. Treatment options are limited, with immune modulating therapies and extracorporeal blood purification still being investigated.
Article
Immunology
Shan Cao, Anne Schnelzer, Nicole Hannemann, Georg Schett, Didier Soulat, Aline Bozec
Summary: The study suggests that the AP-1 transcription factor FRA-1 may play a role in myeloid cell tolerance responses during sepsis by regulating NGAL expression, thus contributing to the resolution of inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Debra M. Foster, John A. Kellum
Summary: Endotoxin, also known as lipopolysaccharide (LPS), induces inflammatory response and can lead to sepsis and septic shock. Quantifying endotoxin and removing it using extracorporeal methods may be beneficial for patients with endotoxic septic shock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lena Larsson, Carlos Garaicoa-Pazmino, Farah Asa'ad, Rogerio Moraes Castilho
Summary: This review presents the current understanding of endotoxin tolerance (ET) in chronic inflammatory diseases and explores its potential connection with periodontitis. Mechanisms and pathways such as Toll-like receptors, nuclear factor κB, immune cell apoptosis, epigenetics, and microRNAs regulate ET and contribute to chronic inflammatory diseases including periodontitis. While the direct relationship between ET and periodontal destruction is not fully understood, evidence suggests potential tolerization of periodontal ligament cells and gingival tissues with reduced levels of Toll-like receptors. Further research is needed to investigate the crucial role of ET in the pathogenesis of periodontal diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Hajime Takashima, Hiroyuki Sugiyama
Summary: TP0586532 effectively inhibits LPS release from Klebsiella pneumoniae, thereby reducing lung inflammation and IL-6 production.
JOURNAL OF ANTIBIOTICS
(2022)
Review
Critical Care Medicine
Claudio Ronco, Lakhmir Chawla, Faeq Husain-Syed, John A. Kellum
Summary: Sepsis and septic shock are still major causes of morbidity and mortality in critically ill patients. The clinical manifestation of these syndromes involves several steps, including microbial invasion, infection establishment, immune response, inflammation, tissue damage, organ dysfunction, and organ crosstalk. Different extracorporeal therapies can be used at different stages to target specific molecules or provide organ support. However, the success of these therapies may need to be evaluated using endpoints other than mortality.
Article
Pharmacology & Pharmacy
Joseph J. Bivona, Madeleine M. Mank, Renee D. Stapleton, D. Clark Files, Michael J. Toth, Matthew E. Poynter
Summary: Skeletal muscle is an important contributor to local and systemic cytokine abundance during inflammatory events. The study reveals the critical involvement of muscle fibers in the early systemic inflammatory cytokine response to endotoxin, showing the direct contribution of myofibers to systemic cytokine production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Multidisciplinary
Ziyue Ling, Chunji Jiang, Xianda Liu, Yupei Li, Weifeng Zhao, Changsheng Zhao
Summary: Researchers have developed a new type of hemoperfusion adsorbent, polyacrylonitrile/polyimidazolium bromide composite microspheres, which exhibit excellent antibacterial properties and endotoxin removal capability, making them suitable for the treatment of sepsis patients.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Xin Shi, Shaopin Zhu, Huiyi Jin, Junwei Fang, Xindan Xing, Yihan Wang, Hanying Wang, Chingyi Wang, Tian Niu, Kun Liu
Summary: The study revealed that KS23 had therapeutic effects on endotoxin-induced uveitis in rats, reduced infiltration of inflammatory cells, and levels of inflammatory cytokines. It also showed inhibitory effects on LPS-stimulated RAW 264.7 cells, suggesting KS23 as a promising therapeutic candidate for ocular inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Johannes Pohlhammer, Matthias Wolfgang Heinzl, Carmen Klammer, Roland Feldbauer, Klemens Rosenberger, Michael Resl, Thomas Wagner, Florian Obendorf, Margot Egger-Salmhofer, Benjamin Dieplinger, Martin Clodi
Summary: This study found that there was a significant difference in how glucose and lipopolysaccharide (LPS) regulate fibroblast growth factor 21 (FGF21) in humans. Glucose administration increased FGF21 expression significantly, while LPS administration lowered FGF21 levels.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Critical Care Medicine
Sergei Rey, Vladimir M. Kulabukhov, Alexander Popov, Olga Nikitina, Gennady Berdnikov, Marat Magomedov, Timur Kim, Sergei Masolitin, Olga Ignatenko, Nikolai Krotenko, Anastasia Marysheva, Nikolai Chaus, Leonid Ohinko, Makarii Mendibaev, Anastasia Chumachenko, Vladimir Pisarev
Summary: Extracorporeal hemoperfusion (EHP) with Efferon LPS cartridges effectively improved the course and outcomes of patients with septic shock. EHP led to increased MAP and arterial oxygenation, decreased norepinephrine doses, and improved organ function. However, there were no significant improvements in survival rates at 14 and 28 days. Laboratory tests showed rapid reductions in inflammatory biomarkers only in the Efferon LPS group.
Review
Biotechnology & Applied Microbiology
Qinbo Yang, Yupei Li, Pazilaiti Tuohuti, Zheng Qin, Zhuyun Zhang, Weifeng Zhao, Baihai Su
Summary: Sepsis, a life-threatening disease caused by endotoxin, lacks specific treatment. Although attempts have been made to use endotoxin adsorbents for blood purification in septic patients, the mortality rate remains high. Future development of endotoxin adsorbents should focus on critical parameters such as dissociation constant and maximum adsorption capacity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Medicinal
Tamara Fedorovna Solov'eva, Svetlana Ivanovna Bakholdina, Gennadii Alexandrovich Naberezhnykh
Summary: This article summarizes the potential of LPS-binding proteins from marine invertebrates as drugs for sepsis treatment. The structure, properties, and activity of these proteins, as well as the potential problems in clinical trials are discussed in detail.
Article
Immunology
Lulu Xu, Weiping Hu, Jing Zhang, Jieming Qu
Summary: This study explored the effects of V1 on acute lung inflammation and found that increased expression of V1 may have a protective role in acute inflammation, while interventions targeting V1 might cause a cytokine storm induced by infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hiroshi Hosoda, Hiroshi Tamura, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Article
Immunology
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
INTERNATIONAL IMMUNOLOGY
(2016)
Article
Immunology
Kaori Suzuki, Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Taisuke Murakami, Zhongshuang Hu, Hiroshi Tamura, Isao Nagaoka
MOLECULAR MEDICINE REPORTS
(2016)
Article
Medicine, Research & Experimental
Zhongshuang Hu, Taisuke Murakami, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara-Arai, Toshiaki Iba, Yoko Tabe, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2017)
Article
Biochemical Research Methods
Johannes Reich, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
Article
Immunology
Kaori Suzuki, Taisuke Murakami, Kyoko Kuwahara-Arai, Hiroshi Tamura, Keiichi Hiramatsu, Isao Nagaoka
INTERNATIONAL IMMUNOLOGY
(2011)
Article
Medicine, Research & Experimental
Kentaro Shibusawa, Taisuke Murakami, Shin Yomogida, Hiroshi Tamura, Isao Nagaoka
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2009)
Article
Medicine, Research & Experimental
Isao Nagaoka, Kaori Suzuki, Taisuke Murakami, Francois Niyonsaba, Hiroshi Tamura, Mchimasa Hirata
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2010)
Article
Multidisciplinary Sciences
Zhongshuang Hu, Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Kyoko Kuwahara-Arai, Toshiaki Iba, Isao Nagaoka
Article
Medicine, Research & Experimental
Taisuke Murakami, Kaori Suzuki, Hiroshi Tamura, Isao Nagaoka
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2011)
Article
Biochemistry & Molecular Biology
Johannes Reich, Felix Alexander Weyer, Hiroshi Tamura, Isao Nagaoka, Hubert Motschmann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Isao Nagaoka, Hiroshi Tamura, Johannes Reich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Hiroshi Tamura, Johannes Reich, Isao Nagaoka
Summary: The blue blood of the horseshoe crab, containing Limulus amebocyte lysate (LAL), is a valuable resource in the biomedical industry for its role in sensitive bacterial and fungal detection. LAL tests have replaced rabbit pyrogen tests in pharmaceutical quality control and show promise as biomarkers for bacterial sepsis and fungal infections. Further advancements in LAL-based endotoxin and beta-glucan assay techniques may enhance the detection of endotoxin in human blood for improved diagnosis and management of related conditions.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.