Review
Biochemistry & Molecular Biology
Gheorghita Isvoranu, Emilia Manole, Monica Neagu
Summary: The CatWalk system is an automated and reliable system for assessing gait abnormalities and motor coordination in animal models of spinal cord and peripheral nerve injuries. Recent studies using CatWalk have focused on injuries in the peripheral nerve, spinal cord, and brain, providing objective and quantifiable data through high-resolution videos. The system is able to evaluate footfall and gait changes, calculate various parameters, and suggest new therapies based on standardized methods for regeneration of peripheral nerve and spinal cord lesions.
Article
Neurosciences
Dana N. Broberg, Dickson Wong, Miranda Bellyou, Manuel Montero-Odasso, Olivier Beauchet, Cedric Annweiler, Robert Bartha
Summary: This study investigated the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on gait performance in APPswe/PS1dE9 mice. The results showed that vitamin D deprivation led to an increase in hind stride width, while treatment with memantine and vitamin D prevented this impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Analytical
Chang Soon Tony Hii, Kok Beng Gan, Nasharuddin Zainal, Norlinah Mohamed Ibrahim, Shahrul Azmin, Siti Hajar Mat Desa, Bart van de Warrenburg, Huay Woon You
Summary: Gait analysis is crucial for detecting biomechanical irregularities, designing personalized rehabilitation plans, and enhancing athletic performance. Current methods for gait assessment have limitations, and markerless gait analysis using 2D pose estimation techniques is challenging to use. This research proposes an automated method using MediaPipe Pose that shows reliable results in temporal gait analysis.
Article
Orthopedics
Ceyhun Caglar, Halil Kara, Okan Ates, Mahmut Ugurlu
Summary: The study demonstrated that intraarticular astaxanthin therapy showed better outcomes in treating osteoarthritis compared to corticosteroid and hyaluronic acid therapies. It can be considered as an effective alternative treatment for OA.
Article
Neurosciences
Johannes C. Heinzel, Viola Oberhauser, Claudia Keibl, Nicole Swiadek, Gregor Laengle, Helen Frick, Jonas Kolbenschlag, Cosima Prahm, Johannes Grillari, David Hercher
Summary: The study demonstrates that computerized gait analysis is a valid and feasible method for evaluating functional recovery following autograft repair of the rat median nerve. Parameters such as Print Area, Duty Cycle, and Stand Index were identified for assessing nerve regeneration. External paw rotation was also identified as a valid parameter for evaluating motor reinnervation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Dandan Jia, Yalan Sun, Guangsen Liu, Meng Xue, Zhihua Huang, Cheng Huang
Summary: Trifluoro-icaritin (ICTF) alleviates mechanical allodynia induced by spared nerve injury (SNI) in rats, enhances gait parameters, and improves motor coordination. After 21 days of ICTF treatment, gait parameters are positively correlated with rotating speed, suggesting ICTF as a potential candidate in managing neuropathic pain.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Zhi Yuan Zheng, Gang Lu, Zhi Qiang Xiong, Chi Kwan Leung, Xian Wei Su, Tu Li, Wai Sang Poon, Wai Yee Chan, George Kwok Chu Wong
Summary: This study investigated the correlation between gait variability and SAH-associated gene expression in a murine model, identifying a strong relationship between gait deficits and the regulation of these genes. Furthermore, the study suggests that p-SP1(453) expression could serve as a potential biomarker for monitoring SAH pathogenesis and a therapeutic target for the condition.
GENES BRAIN AND BEHAVIOR
(2021)
Article
Chemistry, Multidisciplinary
Guoli Zheng, Alexander Younsi, Moritz Scherer, Lennart Riemann, Johannes Walter, Thomas Skutella, Andreas Unterberg, Klaus Zweckberger
Summary: By studying the validity and relevance of CatWalk XT(R) gait analysis in a cervical SCI rat model, researchers found that severe spinal cord injury caused significant gait impairment, but most parameters showed significant spontaneous recovery in the following weeks, with a stronger correlation with the percentage of preserved tissue.
APPLIED SCIENCES-BASEL
(2021)
Article
Anatomy & Morphology
Tobias Fritz, Julia Schaefer, Claudia Scheuer, Janine Stutz, Tina Histing, Tim Pohlemann, Michael D. Menger, Matthias W. Laschke, Moritz Klein, Marcel Orth
Summary: The study found that the use of the pro-inflammatory mediator MALP-2 in injured tendons delayed the healing process, likely due to increased intracellular stress and suppressed cell proliferation. Therefore, the application of MALP-2 is not recommended for the treatment of tendon injuries.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2022)
Review
Clinical Neurology
Felix Javier Jimenez-Jimenez, Hortensia Alonso-Navarro, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The coexistence of peripheral neuropathy (PN) and restless legs syndrome (RLS) is relatively frequent, with RLS reported in 5.2%-53.7% of PN patients, and PN reported in 0%-87.5% of RLS patients, both significantly higher than controls. Variability across studies may be due to differences in diagnostic criteria. RLS is a common clinical complaint in patients with PN of different etiologies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniel Umansky, Kathleen M. Hagen, Tak Ho Chu, Rajesh K. Pathiyil, Saud Alzahrani, Shalina S. Ousman, Rajiv Midha
Summary: This study developed a standardized model of stretch-crush sciatic nerve injury in mice and compared the outcomes of crush and stretch-crush injuries using various gait analysis methods. The results showed that stretch-crush injuries were more severe than crush-only injuries. However, the behavioral outcomes were comparable between the two groups. The study also found potential applications for semi-automated and deep learning-based gait analysis methods in evaluating mouse hind-limb nerve injuries, but further validation is needed.
Article
Oncology
Martial Caillaud, Nipa H. Patel, Wisam Toma, Alyssa White, Danielle Thompson, Jared Mann, Tammy H. Tran, Jane L. Roberts, Justin L. Poklis, John W. Bigbee, Xianjun Fang, David A. Gewirtz, M. Imad Damaj
Summary: The study demonstrates the therapeutic potential of fenofibrate in preventing paclitaxel-induced peripheral neuropathy by reducing pain symptoms through modulation of PPAR-alpha expression and decreasing neuroinflammation. This suggests a possible repurposing of fenofibrate in the clinic for preventing paclitaxel-induced neuropathy.
Article
Dermatology
Mar Sempere-Bigorra, Lorenzo Brognara, Ivan Julian-Rochina, Antonio Mazzotti, Omar Cauli
Summary: This study explores the potential usefulness of gait analysis parameters using a single sensor unit to detect peripheral neuropathy in diabetic patients with diabetic foot. The study finds significant correlations between impaired deep sensory pathways and gait impairments in diabetic patients, as well as significant correlations between all gait parameters and the superficial sensory pathway. The findings suggest that inertial sensors could be a useful tool for diagnosing gait alterations and evaluating treatment effects in diabetic patients to improve gait and reduce the risk of falls.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cell Biology
Shanshan Zhong, Fangxi Liu, Rashid Giniatullin, Jukka Jolkkonen, Yong Li, Zhike Zhou, Xinyu Lin, Chang Liu, Xiuchun Zhang, Zhouyang Liu, Cheng Lv, Qianqian Guo, Chuansheng Zhao
Summary: This study analyzed the microbiome and metabolome of feces and serum from breast cancer patients receiving paclitaxel treatment. The results showed that increased levels of deoxycholic acid (DCA) due to the growth of Clostridium species were associated with severe neuropathy. DCA further induced overexpression of CCR5 in dorsal root ganglion (DRG) through the TGR5 receptor, leading to neuronal hyperexcitability. Inhibition of CCR5 suppressed the development of neuropathic nociception.
Article
Plant Sciences
Nari Kim, Geehoon Chung, So-Ri Son, Jae Hyun Park, Young Hyun Lee, Keon-Tae Park, Ik-Hyun Cho, Dae Sik Jang, Sun Kwang Kim
Summary: This study aimed to investigate the suppressive effects of magnolin, an ERK inhibitor substance derived from Magnolia denudata seeds, on the symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The results showed that magnolin administration exerted an analgesic effect on CIPN-induced cold allodynia and inhibited ERK phosphorylation in the dorsal root ganglion (DRG). These results suggest that magnolin could be developed as an alternative treatment to suppress paclitaxel-induced neuropathic pain symptoms.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Patrick Dupont, Soren Christensen, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Gotz Thomalla, Robin Lemmens
Summary: This study evaluated the ability of quantitative DWI and FLAIR to predict DWI-FLAIR mismatch in ischemic stroke. The results showed that the agreement between quantitative parameters and DWI-FLAIR mismatch was insufficient and there was a moderate correlation between the two quantitative parameters. The interquartile range rDWI SI was found to be associated with excellent functional outcome.
Article
Public, Environmental & Occupational Health
Mayowa O. Owolabi, Amanda G. Thrift, Ajay Mahal, Marie Ishida, Sheila Martins, Walter Johnson, Jeyaraj Pandian, Foad Abd-Allah, Joseph Yaria, Hoang T. Phan, Greg Roth, Seana L. Gall, Richard Beare, Thanh G. Phan, Robert Mikulik, Rufus O. Akinyemi, Bo Norrving, Michael Brainin, Valery L. Feigin
Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.
LANCET PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Petra Huehnchen, Christian Schinke, Nikola Bangemann, Adam D. Dordevic, Johannes Kern, Smilla K. Maierhof, Lois Hew, Luca Nolte, Peter Koertvelyessy, Jens C. Goepfert, Klemens Ruprecht, Christopher J. Somps, Jens-Uwe Blohmer, Jalid Sehouli, Matthias Endres, Wolfgang Boehmerle
Summary: This study identifies neurofilament light chain (NFL) as a potential biomarker for chemotherapy-induced polyneuropathy (CIPN). In an in vitro model, NFL was released from sensory neurons treated with paclitaxel and showed an inverse correlation with cell viability. In a clinical study, NFL concentrations significantly increased in paclitaxel-treated patients with CIPN but not in patients receiving chemotherapy without CIPN or controls. This suggests that NFL could serve as a biomarker for early diagnosis of CIPN.
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Clinical Neurology
Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig, Helena Stengl, Jan F. Scheitz, Thomas Elgeti, Sebastian N. Nagel, Matthias Endres, Karl Georg Haeusler, Christian H. Nolte
Summary: This study found that elevated cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT) and brain natriuretic peptide (BNP), in acute stroke patients are strongly associated with pathological findings on cardiac magnetic resonance imaging (CMR). The elevation of these biomarkers may help identify patients who require a more comprehensive cardiology work-up.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Thomas Ihl, Michael Ahmadi, Inga Laumeier, Maureen Steinicke, Caroline Ferse, Philipp Klyscz, Matthias Endres, Sidsel Hastrup, Holger Poppert, Frederick Palm, Farid Kandil, Joachim E. Weber, Paul Von Weitzel-Mudersbach, Martin L. J. Wimmer, Heinrich J. Audebert
Summary: The INSPiRE-TMS trial investigated the effects of a multicomponent support program in patients with nondisabling stroke or transient ischemic attack, showing that the intensified care group had slightly better results for physical fitness and modified Rankin Scale after 1 year, but none of the other patient-centered outcomes were significantly improved.
Article
Clinical Neurology
Ewgenia Barow, Fanny Quandt, Bastian Cheng, Mathias Gelderblom, Maerit Jensen, Alina Koenigsberg, Florent Boutitie, Norbert Nighoghossian, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Goetz Thomalla
Summary: Higher white blood cell count is associated with poor functional outcome in acute ischemic stroke, independent of treatment with alteplase. Elevated white blood cell count is also associated with increased risk of hemorrhagic transformation and larger stroke volume.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Petra Huehnchen, Nikola Bangemann, Sandra Lischewski, Stefanie Maerschenz, Friedemann Paul, Tanja Schmitz-Huebsch, Jens-Uwe Blohmer, Cornelia Eberhardt, Geraldine Rauch, Agnes Floeel, Sophie Adam, Philipp Schwenkenbecher, Ivo Meinhold-Heerlein, Oliver Hoffmann, Tjalf Ziemssen, Matthias Endres, Wolfgang Boehmerle
Summary: This study aims to investigate the efficacy of lithium carbonate in the treatment of paclitaxel-induced polyneuropathy and cognitive impairment. The research will be conducted as a randomized, double-blind trial comparing the lithium carbonate group with the placebo group. The primary endpoint is the reduction in neuropathy score two weeks after the last paclitaxel infusion.
FRONTIERS IN MEDICINE
(2022)
Editorial Material
Clinical Neurology
Leonie Mueller-Jensen, Helene Kriedemann, Kerstin Anvari, Petra Huehnchen, Volker Siffrin
Summary: A 46-year old man with controlled relapsing-remitting multiple sclerosis (MS) and long-term fingolimod treatment developed multiple painful skin lesions. Monkeypox virus infection was revealed by outpatient skin swab. The patient experienced prolonged cutaneous, oral and perianal manifestations, proctitis, gastrointestinal bleeding requiring blood transfusions, lower leg phlegmon, lymphadenopathy, hyperbilirubinemia, acute urinary retention, and hematuria.
Article
Immunology
Leonie Mueller-Jensen, Samuel Knauss, Lorena Ginesta Roque, Christian Schinke, Smilla K. Maierhof, Frederik Bartels, Carsten Finke, Kristin Rentzsch, Claas Ulrich, Raphael Mohr, Werner Stenzel, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen
Summary: In this study, the characteristics and clinical significance of neuronal autoantibodies in patients treated with immune checkpoint inhibitors (ICI) were investigated. It was found that the prevalence of neuromuscular autoantibodies was higher in patients with irAE-n compared to those without irAE-n. However, the pathogenic significance of brain-reactive autoantibodies in ICI-treated patients remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Leonie Mueller-Jensen, Axel R. Schulz, Henrik E. Mei, Raphael Mohr, Claas Ulrich, Philipp Knape, Nikolaj Frost, Stefan Frischbutter, Desiree Kunkel, Christian Schinke, Lorena Ginesta Roque, Smilla K. Maierhof, Florian T. Nickel, Lucie Heinzerling, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen, Samuel Knauss
Summary: This observational study found profound dysregulation of immune cells, particularly CD8+ T cells and B cells, in patients with irAE-n. Furthermore, the study identified a potential biomarker, CXCL10, for irAE-n.