Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

FiloQuant reveals increased filopodia density during breast cancer progression

(2017) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ph − myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

(2016) Nuria Socoro-Yuste et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines

(2016) Lara Toffali et al.   JOURNAL OF IMMUNOLOGY

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

(2016) Nagaraj S. Nagathihalli et al.   Oncotarget

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics

(2015) Takashi Watanabe et al.   CELL STRUCTURE AND FUNCTION

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

IQGAPs choreograph cellular signaling from the membrane to the nucleus

(2015) Jessica M. Smith et al.   TRENDS IN CELL BIOLOGY

Inhibition of Endoglin-GIPC Interaction Inhibits Pancreatic Cancer Cell Growth

(2014) K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

IL-6 and related cytokines as the critical lynchpins between inflammation and cancer

(2014) Koji Taniguchi et al.   SEMINARS IN IMMUNOLOGY

Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

(2013) Y. Zhang et al.   CANCER RESEARCH

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Signal Transducer and Activator of Transcription 3 (STAT3) Regulates Collagen-Induced Platelet Aggregation Independently of Its Transcription Factor Activity

(2012) Zhou Zhou et al.   CIRCULATION

Local axonal function of STAT3 rescues axon degeneration in thepmnmodel of motoneuron disease

(2012) Bhuvaneish Thangaraj Selvaraj et al.   JOURNAL OF CELL BIOLOGY

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression

(2011) Akihisa Fukuda et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis

(2011) R. B. Corcoran et al.   CANCER RESEARCH

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro

(2011) C. HUANG et al.   NEOPLASMA

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation

(2009) Jeong-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator  PIX

(2009) T. S. Teng et al.   JOURNAL OF CELL SCIENCE