Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health

Metabolic engineering approaches for production of biochemicals in food and medicinal plants

(2014) Sarah A. Wilson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Validated HILIC–MS/MS assay for determination of vindesine in human plasma: Application to a population pharmacokinetic study

(2014) Rong-Hua Zhu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus

(2014) Guitele Goldhaber-Pasillas et al.   MOLECULES

Synergistic and additive influence of cyclodextrins and methyl jasmonate on the expression of the terpenoid indole alkaloid pathway genes and metabolites in Catharanthus roseus cell cultures

(2014) Lorena Almagro et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Effect of Chromium on Antioxidant Potential ofCatharanthus roseusVarieties and Production of Their Anticancer Alkaloids: Vincristine and Vinblastine

(2014) Vartika Rai et al.   Biomed Research International

Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy

(2013) J. Bellmunt et al.   ANNALS OF ONCOLOGY

Interaction between abscisic acid and nitric oxide in PB90-induced catharanthine biosynthesis ofcatharanthus roseuscell suspension cultures

(2013) Qian Chen et al.   BIOTECHNOLOGY PROGRESS

The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway

(2013) Chun Li et al.   BMC PLANT BIOLOGY

Heteromeric and Homomeric Geranyl Diphosphate Synthases from Catharanthus roseus and Their Role in Monoterpene Indole Alkaloid Biosynthesis

(2013) Avanish Rai et al.   Molecular Plant

Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don

(2013) Soon Tiong et al.   MOLECULES

Deciphering the molecular mechanisms of anti-tubulin plant derived drugs

(2013) P. Barbier et al.   PHYTOCHEMISTRY REVIEWS

Vacuolar Transport of the Medicinal Alkaloids from Catharanthus roseus Is Mediated by a Proton-Driven Antiport

(2013) I. Carqueijeiro et al.   PLANT PHYSIOLOGY

ATP-binding cassette transporter controls leaf surface secretion of anticancer drug components in Catharanthus roseus

(2013) F. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The oxidative stress response of the opportunistic fungal pathogen Candida glabrata

(2013) Marcela Briones-Martin-Del-Campo et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

Tubulin-based Structure-affinity Relationships for Antimitotic Vinca Alkaloids

(2012) Claire Coderch et al.   Anti-Cancer Agents in Medicinal Chemistry

CrMPK3, a mitogen activated protein kinase from Catharanthus roseus and its possible role in stress induced biosynthesis of monoterpenoid indole alkaloids

(2012) Susheel Raina et al.   BMC PLANT BIOLOGY

Overexpression of ORCA3 and G10H in Catharanthus roseus Plants Regulated Alkaloid Biosynthesis and Metabolism Revealed by NMR-Metabolomics

(2012) Qifang Pan et al.   PLoS One

Catharoseumine, a new monoterpenoid indole alkaloid possessing a peroxy bridge from Catharanthus roseus

(2012) Lei Wang et al.   TETRAHEDRON LETTERS

Feasibility and influencing factors of laser cutting of tomato peduncles for robotic harvesting

(2011) Liu   AFRICAN JOURNAL OF BIOTECHNOLOGY

Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus

(2011) Monika Jaggi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Molecular docking and pharmacogenomics of Vinca alkaloids and their monomeric precursors, vindoline and catharanthine

(2011) Serkan Sertel et al.   BIOCHEMICAL PHARMACOLOGY

Effect of sodium nitroprusside on growth and terpenoid indole alkaloid production in Catharanthus roseus hairy root cultures

(2011) Mai Li et al.   BIOTECHNOLOGY PROGRESS

Oral vinorelbine in metastatic breast cancer: A review of current clinical trial results

(2011) Matti Aapro et al.   CANCER TREATMENT REVIEWS

Vinflunine: drug safety evaluation of this novel synthetic vinca alkaloid

(2011) Fabio AB Schutz et al.   Expert Opinion On Drug Safety

Thermodynamics of calmodulin and tubulin binding to the vinca-alkaloid vinorelbine

(2011) P. O. Tsvetkov et al.   MOLECULAR BIOLOGY

Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids

(2011) Berrin Özçelik et al.   PHARMACEUTICAL BIOLOGY

The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus

(2011) Hongtao Zhang et al.   PLANT JOURNAL

The Transcription Factor CrWRKY1 Positively Regulates the Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus

(2011) N. Suttipanta et al.   PLANT PHYSIOLOGY

Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots

(2011) K. X. Tang et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture

(2010) Mei-Liang Zhou et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New method to enhance ajmalicine production in Catharanthus roseus cell cultures based on the use of cyclodextrins

(2010) L. Almagro et al.   BIOTECHNOLOGY LETTERS

Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus

(2010) Grégory Guirimand et al.   JOURNAL OF PLANT PHYSIOLOGY

The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots

(2010) Christie A.M. Peebles et al.   METABOLIC ENGINEERING

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

(2010) Cui-Ting Wang et al.   PLANT CELL REPORTS

Methyl jasmonic acid induced expression pattern of terpenoid indole alkaloid pathway genes in Catharanthus roseus seedlings

(2010) Shu Wei   PLANT GROWTH REGULATION

Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle

(2010) J. Roepke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of cellular differentiation and elicitation on intermediate and late steps of terpenoid indole alkaloid biosynthesis in Catharanthus roseus

(2010) Ashutosh K. Shukla et al.   PROTOPLASMA

The effects of UV-B stress on the production of terpenoid indole alkaloids inCatharanthus roseushairy roots

(2009) Bernard Y. K. Binder et al.   BIOTECHNOLOGY PROGRESS

Vinflunine: A New Microtubule Inhibitor Agent

(2008) J. Bennouna et al.   CLINICAL CANCER RESEARCH

Differential Secretion and Accumulation of Terpene Indole Alkaloids in Hairy Roots of Catharanthus roseus Treated with Methyl Jasmonate

(2008) Eliel Ruiz-May et al.   MOLECULAR BIOTECHNOLOGY