Article
Medicine, Research & Experimental
Mohsen Keshavarz, Forough Shamsizadeh, Ahmad Tavakoli, Neda Baghban, Arezoo Khoradmehr, Ali Kameli, Poorya Rasekh, Adel Daneshi, Iraj Nabipour, Katayoun Vahdat, Maryam Farrokhnia, Amin Tamadon
Summary: The ethanolic extract of Holothuria parva demonstrates significant antiviral activities against HSV-1 by reducing virus titers and interfering with virus attachment to cell receptors. Octadecanoic acid 2-hydroxy-1-(hydroxymethyl) ethyl ester and 2',6'-acetoxylidide are major constituents in the extract. Computational docking analysis suggests that the extract compounds may inhibit virus attachment by covering both virus and host cell binding domains.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Kai Jiang, Jing Feng, Xia Qi, Lili Ran, Lixin Xie
Summary: This study validated the inhibitory effect of oridonin on herpes simplex virus type 1 and demonstrated its potential in alleviating herpes simplex keratitis infection in mice.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Plant Sciences
Guadalupe Cantero-Gonzalez, Nelson Alvarenga, Marcos M. Florentin-Pavia, Pamela Gonzalez-Maldonado, Pablo H. Sotelo
Summary: This study analyzed the chemical composition and antiviral activity of Acanthospermum australe and Acanthospermum hispidum, and found that they have inhibitory effects against herpes simplex virus 1 (HSV-1). Certain components of these plants can interfere with different steps of viral propagation, demonstrating good antiviral activity against HSV-1.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Mehdi Gholami Barzoki, Somayeh Shatizadeh Malekshahi, Mohammad Shayestehpour
Summary: This study investigated the potential antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against HSV-1 for the first time. The results showed that S. clausii and its supernatant had the greatest inhibitory activity toward HSV-1 in the pre-treatment assay, indicating their potential as a novel inhibitor for HSV-1 infection.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Lorena da Graca Pedrosa de Macena, Leonardo dos Santos Correa Amorim, Kaue Francisco Correa de Souza e Souza, Luiza Dantas Pereira, Claudio Cesar Cirne dos Santos, Caroline de Souza Barros, Carlos Jose Brito Ramos, Marcos Vinicius Santana, Helena Carla Castro, Valeria Laneuville Teixeira, Ana Maria Viana Pinto, Helena de Souza Pereira, Izabel Christina Nunes de Palmer Paixao
Summary: Herpes simplex virus type 2 (HSV-2) is a common sexually transmitted infection, but currently there is no available vaccine. The commonly used drug acyclovir has reduced efficacy due to the emergence of resistant strains. This study evaluated the anti-HSV-2 activity of two compounds isolated from marine seaweed and found that one of them could be a potential alternative therapy for HSV-2.
NATURAL PRODUCT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hiroki Kondo, Tetsuo Koshizuka, Ryuichi Majima, Keita Takahashi, Ken Ishioka, Tatsuo Suzutani, Naoki Inoue
Summary: The compound 147B3 has shown efficacy in inhibiting HCMV and HSV-1 infection, potentially by targeting viral transactivators through their interaction with factors required for the viral gene expression system.
ANTIVIRAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Alexia Damour, Magali Garcia, Hye-Sun Cho, Andy Lariviere, Nicolas Leveque, Chankyu Park, Charles Bodet
Summary: Hg-CATH and Pb-CATH4, derived from Heterocephalus glaber and Python bivittatus, were found to exhibit potent antiviral activity against herpes simplex virus, making them potential candidates for new therapies targeting HSV-1.
Article
Virology
Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
Summary: CDK inhibitors, such as BMS-265246, have shown potential as effective antiviral agents against HSV-1 infection by inhibiting viral replication at multiple stages.
Article
Medicine, Research & Experimental
Catielen Paula Pavi, Isabella Dai Pra, Rafael Dorighello Cadamuro, Isamu Kanzaki, Jhuly Wellen Ferreira Lacerda, Louis Pergaud Sandjo, Roberto Messias Bezerra, Jorge Federico Orellana Segovia, Gislaine Fongaro, Izabella Thais Silva
Summary: This study evaluated the activity of seventeen extracts derived from eight Amazonian medicinal plants against herpes simplex virus and chikungunya virus. Four extracts exhibited significant activity against both viruses, including the drug-resistant strains. Virucidal tests showed a higher level of virucidal activity compared to antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ji Xiao, Miaomiao Cai, Yifei Wang, Ping Ding
Summary: The iridoid compounds in traditional Chinese medicine have significant antiviral effects. This study identified seven new iridoid compounds from the aerial parts of Morinda officinalis, with officinaloside C showing significant anti-HSV-1 activity.
Article
Biochemistry & Molecular Biology
Mabroka H. Saad, Nagwa M. Sidkey, Rizwan Hasan Khan, Esmail M. El-Fakharany
Summary: In this study, two types of lectins were purified from Nostoc muscorum and characterized for their physical properties and antiviral activity. Nostoc muscorum showed potential as a unique source for antiviral drug discovery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Anna Luganini, Giulia Sibille, Barbara Mognetti, Stefano Sainas, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Marco L. Lolli, Giorgio Gribaudo
Summary: The new generation inhibitor MEDS433 shows strong antiviral activity against HSV-1 and HSV-2 in vitro by preventing the accumulation of viral genomes and reducing late gene expression, indicating its mechanism of action as inhibition of DHODH activity.
ANTIVIRAL RESEARCH
(2021)
Article
Clinical Neurology
Pingting Zhong, Siwen Zang, Honghua Yu, Xiaohong Yang
Summary: This case highlights the importance of initiating antiviral therapy in suspected viral encephalitis patients, regardless of early virologic results, to prevent missed diagnosis and complications, especially when systemic steroid treatment is being considered.
Article
Tropical Medicine
Wen-Da Wang, Gang Chen
Summary: The compound mangiferin, isolated from the rhizome of Anemarrhena asphodeloides, exhibited significant antiviral activity against HSV-1 both in vitro and in vivo. It inhibited the replication of HSV-1, attenuated mitochondrial damage, and reduced the expression of inflammatory factors. It has the potential to be a promising antiviral agent against HSV-1.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Review
Chemistry, Medicinal
Ashraf A. Abbas, Magda H. Abdellattif, Kamal M. Dawood
Summary: This review discusses the biological and pharmacological potentials of bipyrazole derivatives from 2010 to 2021 including anticancer, antioxidant, anti-inflammatory, antimicrobial, antitubercular, antimalarial, insecticidal activities, and enzymatic inhibitions. Bipyrazoles show promising activities against various diseases, making them valuable for medicinal researchers. Metallated bipyrazoles, such as gold(III) and iridium(II) complexes, exhibit better biological activities than bipyrazole ligands, while copper(I) and silver(I) complexes show excellent antibacterial activities. Several bipyrazoles are reported to be better antimalarial inhibitors than chloroquine, a potential drug for COVID-19.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2022)
Article
Chemistry, Physical
Reda M. Abdelhameed, Mohamed Taha, Hassan Abdel-Gawad, Hossam E. Emam
Summary: In this study, iron-based metal organic frameworks (Fe-MOF) were successfully used for removing diazinon insecticide from soybean oil. Fe-MOF-2 showed a higher Langmuir removal capacity and better recycling results. The adsorption mechanism involved a combination of physical deposition and electrostatic reactions as explored by Monte Carlo simulation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Oncology
Kamal M. Dawood, Mohamed A. Raslan, Ashraf A. Abbas, Belal E. Mohamed, Mohamed S. Nafie
Summary: This study synthesized novel bis-amide-based bis-thiazoles and thiadiazoles and evaluated their anti-cancer activities. Compound 7f showed significant cytotoxicity against colorectal cancer cells and induced cell apoptosis by regulating the expression of relevant genes. In vivo studies demonstrated that compound 7f inhibited tumor growth and improved hematological and biochemical parameters. Therefore, compound 7f is considered as a promising candidate for further development as a chemotherapeutic anti-cancer agent.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Eman M. Elattar, Mona Shaban, Hassan-Elrady A. Saad, Farid A. Badria, Amal A. Galala
Summary: In this study, vanillin was used as a starting material to synthesize five new triazole derivatives and one known derivative through click chemistry. The newly synthesized compounds showed enhanced antimicrobial and antifungal activities, while compounds 1 and 2 exhibited high antiquorum-sensing activity. Compounds 4-7 demonstrated selective cytotoxicity against cancer cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Rowida M. Omar, Farid A. Badria, Amal A. Galala
Summary: In current drug discovery, there is a growing focus on designing drug molecules that interact with multiple targets simultaneously (exhibiting compound promiscuity). Previous screening research on 54 medicinal plants found that the methanol extract of Phylanthus emblica L. leaves showed promising inhibitory activity against alpha amylase, tyrosinase, and hyaluronidase enzymes. Further fractionation of the extract led to the isolation of two flavone glycosides, with one of them, luteolin-7-O-a-L-rhamnoside, exhibiting strong inhibitory activity against the enzymes. This study suggests that luteolin-7-O-a-L-rhamnoside could be used as a potential promiscuous enzyme inhibitor for the management and treatment of certain chronic diseases.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Reda M. Abdelhameed, Mahmoud El-Shahat, Hassan Abdel-Gawad, Bahira Hegazi
Summary: The current paper describes the application of newly formulated beads from copper-benzenetricarboxylate (Cu-BTC), polyacrylonitrile (PAN), and chitosan (C), Cu-BTC@C-PAN, C-PAN, and PAN, for the removal of phenolic chemicals from water. The adsorption optimization of 4-chlorophenol (4-CP) and 4-nitrophenol (4-NP) using beads was studied, including the effects of various experimental factors. The Langmuir model and pseudo-second-order kinetic equation were found to be suitable for explaining the adsorption isotherms and kinetics of the system. Cu-BTC@C-PAN beads showed higher adsorption capacities compared to PAN for both 4-CP and 4-NP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Reem A. ElGamal, Amal A. Galala, Maged S. Abdel-Kader, Farid A. Badria, Amal F. Soliman
Summary: The biotransformation of vulgarin, a sesquiterpene lactone obtained from Artemisia judaica, was performed by Aspergillus niger to produce three more polar metabolites. The structures of these metabolites were determined using NMR spectroscopy and HRESIMS. The anti-inflammatory activity of vulgarin and its metabolites was evaluated, and vulgarin showed preferential inhibitory activity against COX-2, while its metabolite (3a) exhibited selective inhibition against COX-1.
Article
Chemistry, Multidisciplinary
Mostafa E. Salem, Esraa M. Mahrous, Eman A. Ragab, Mohamed S. Nafie, Kamal M. Dawood
Summary: A new compound, 3-bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole, was synthesized and used as a key building block for constructing molecular hybrids. The resulting hybrids showed potent cytotoxicity against liver cancer and promising EGFR/HER2 inhibition activity.
Article
Chemistry, Organic
Ahmad M. Farag, Nabila A. Kheder, Asmaa M. Fahim, Kamal M. Dawood
Summary: The title compounds were synthesized in good yields starting from 3-oxo-N-(3-pyridyl)butanamide as the key intermediate. Various reactions were carried out, leading to the formation of pyrazole-carboxamides, bis-pyridine, hydrazone, and pyrazolo[5,1-c]-1,2,4-triazine derivative. The synthesized compounds were characterized using IR, NMR spectroscopy, and mass spectrometry.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mostafa E. Salem, Esraa M. Mahrous, Eman A. Ragab, Mohamed S. Nafie, Kamal M. Dawood
Summary: The target compounds were synthesized and their structures were determined through spectroscopic and analytical data. Compounds 4b, 4c, and 6a showed strong cytotoxicity against MCF-7 cells and were safe for MCF10A cells. These compounds also showed promising dual EGFR and CDK-2 inhibition activities, with 6a being the most effective.
Article
Chemistry, Multidisciplinary
Abdulrahman M. Alazemi, Kamal M. Dawood, Hamad M. Al-Matar, Wael M. Tohamy
Summary: 3-oxo-2-arylhydrazonopropanals and acetoacetanilide reacted under DBU/1,4-dioxane/microwave irradiation conditions, resulting in selective formation of 4-arylazo-5-hydroxy-benzamide derivatives. The structures of the obtained compounds were characterized using various spectroscopic techniques, and X-ray single crystals were obtained for three examples. The photophysical properties of the new products were evaluated, particularly their absorption and emission spectra, providing valuable information on their optical properties. The new compounds exhibited green fluorescence at 513-549 nm under UV irradiation in acetone solution.
Review
Chemistry, Multidisciplinary
Ashraf A. Abbas, Kamal M. Dawood
Summary: The benzofuran moiety is a key component in numerous biologically active natural and synthetic heterocycles. These heterocycles exhibit unique therapeutic potential and are implicated in various clinical drugs. Recent studies have confirmed the exceptional inhibitory potency of benzofurans against human cancer cell lines compared to reference anticancer drugs. Several publications have focused on the anticancer properties of benzofuran-based heterocycles. This review comprehensively covers the latest developments in the anticancer activities of natural and synthetic benzofuran scaffolds from 2019 to 2022, highlighting their potential as promising candidates for anticancer agents.
Article
Biotechnology & Applied Microbiology
Wael Mahmoud Aboulthana, Noha El-Sayed Ibrahim, Amgad Kamal Hassan, Wagdy Khalil Bassaly, Hassan Abdel-Gawad, Hamdy Ahmed Taha, Kawkab A. Ahmed
Summary: Our study showed that the nano-extract effectively reduced the toxicity induced by CPF in rats at hematological, biochemical, histopathological, physiological, and molecular levels, in the group pre-treated with the nano-extract.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Fatma M. Thabet, Kamal M. Dawood, Eman A. Ragab, Mohamed S. Nafie, Ashraf A. Abbas
Summary: A series of new compounds were synthesized and evaluated for their cytotoxicity and apoptosis-inducing ability. Among them, compound 8i showed promising anti-breast cancer activity and potential for drug development.
Article
Chemistry, Multidisciplinary
Reda M. Abdelhameed, Hassan Abdel-Gawad
Summary: Nanoporous metal-organic frameworks (MOFs) are highly porous and crystalline materials with tunable physiochemical properties. 2-Amino-1,4-benzenedicarboxylic acid plays a crucial role in the synthesis and post-synthetic modification of MOFs, reacting with various metals to produce MOFs with different structures. These functionalized MOFs can also react with organic reagents to generate new applications.
EGYPTIAN JOURNAL OF CHEMISTRY
(2022)
