An Upper Limit on the Functional Fraction of the Human Genome

New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens

(2017) Jean-Jacques Hublin et al.   NATURE

Negative selection in humans and fruit flies involves synergistic epistasis

(2017) Mashaal Sohail et al.   SCIENCE

The mutation rate in human evolution and demographic inference

(2016) Aylwyn Scally   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome

(2016) Heming Wang et al.   GENETIC EPIDEMIOLOGY

Mutation Rate Variation is a Primary Determinant of the Distribution of Allele Frequencies in Humans

(2016) Arbel Harpak et al.   PLoS Genetics

An Evolutionary Classification of Genomic Function

(2015) Dan Graur et al.   Genome Biology and Evolution

Are Synonymous Sites in Primates and Rodents Functionally Constrained?

(2015) Nicholas Price et al.   JOURNAL OF MOLECULAR EVOLUTION

Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes

(2015) Mark Lipson et al.   PLoS Genetics

Determinants of Mutation Rate Variation in the Human Germline

(2014) Laure Ségurel et al.   Annual Review of Genomics and Human Genetics

Population-Genetic Influences on Genomic Estimates of the Inbreeding Coefficient: A Global Perspective

(2014) Trevor J. Pemberton et al.   HUMAN HEREDITY

Getting "function" right

(2014) T. D. P. Brunet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage

(2014) Chris M. Rands et al.   PLoS Genetics

Human Evolution: Turning Back the Clock

(2013) Richard E. Green et al.   CURRENT BIOLOGY

On the Immortality of Television Sets: "Function" in the Human Genome According to the Evolution-Free Gospel of ENCODE

(2013) D. Graur et al.   Genome Biology and Evolution

Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation

(2012) Jacob J. Michaelson et al.   CELL

Rates and Fitness Consequences of New Mutations in Humans

(2012) Peter D. Keightley   GENETICS

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Estimating the human mutation rate using autozygosity in a founder population

(2012) Catarina D Campbell et al.   NATURE GENETICS

Nuclear genome size: Are we getting closer?

(2010) Jaroslav Doležel et al.   CYTOMETRY PART A

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing

(2010) J. C. Roach et al.   SCIENCE

Spontaneous Mutation Accumulation Studies in Evolutionary Genetics

(2009) Daniel L. Halligan et al.   Annual Review of Ecology Evolution and Systematics

Human Y Chromosome Base-Substitution Mutation Rate Measured by Direct Sequencing in a Deep-Rooting Pedigree

(2009) Yali Xue et al.   CURRENT BIOLOGY

Distributions of Selectively Constrained Sites and Deleterious Mutation Rates in the Hominid and Murid Genomes

(2009) L. Eory et al.   MOLECULAR BIOLOGY AND EVOLUTION

Estimating the Rate of Adaptive Molecular Evolution in the Presence of Slightly Deleterious Mutations and Population Size Change

(2009) A. Eyre-Walker et al.   MOLECULAR BIOLOGY AND EVOLUTION