Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation

Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms

(2016) Carl Julien et al.   HUMAN MOLECULAR GENETICS

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin

(2016) James W. Connell et al.   PLoS One

Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia

(2016) Gautam Wali et al.   Scientific Reports

Hereditary spastic paraplegia SPG4: what is known and not known about the disease

(2015) Joanna M. Solowska et al.   BRAIN

Regulation of Axonal Transport by Protein Kinases

(2015) Katherine L. Gibbs et al.   TRENDS IN BIOCHEMICAL SCIENCES

Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

(2015) Lanfranco Leo et al.   Cell Reports

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

(2015) Dick Jaarsma et al.   Frontiers in Neuroscience

The Alu-Rich Genomic Architecture of SPAST Predisposes to Diverse and Functionally Distinct Disease-Associated CNV Alleles

(2014) Philip M. Boone et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

(2014) S. Havlicek et al.   HUMAN MOLECULAR GENETICS

Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

(2014) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms

(2013) John K. Fink   ACTA NEUROPATHOLOGICA

Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase

(2013) Gerardo A. Morfini et al.   PLoS One

Loss of Spastin Function Results in Disease-Specific Axonal Defects in Human Pluripotent Stem Cell-Based Models of Hereditary Spastic Paraplegia

(2013) Kyle R. Denton et al.   STEM CELLS

A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations

(2012) G. Abrahamsen et al.   Disease Models & Mechanisms

Mitotic Motors Coregulate Microtubule Patterns in Axons and Dendrites

(2012) S. Lin et al.   JOURNAL OF NEUROSCIENCE

Early and Selective Impairments in Axonal Transport Kinetics of Synaptic Cargoes Induced by Soluble Amyloid β-Protein Oligomers

(2012) Yong Tang et al.   TRAFFIC

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

(2012) Michelle C. Stone et al.   Cell Reports

Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation

(2011) Eduarda Dráberová et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

(2011) N. M. Kanaan et al.   JOURNAL OF NEUROSCIENCE

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Distinct intracellular vesicle transport mechanisms are selectively modified by spastin and spastin mutations

(2010) Julia C. Fuerst et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

(2010) Seong H. Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts

(2010) H. Sudo et al.   JOURNAL OF NEUROSCIENCE

Hereditary spastic paraplegias: membrane traffic and the motor pathway

(2010) Craig Blackstone et al.   NATURE REVIEWS NEUROSCIENCE

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Basic Fibroblast Growth Factor Elicits Formation of Interstitial Axonal Branches via Enhanced Severing of Microtubules

(2009) Liang Qiang et al.   MOLECULAR BIOLOGY OF THE CELL

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinesin I family member KIF5C is a novel substrate for protein kinase CK2

(2008) Barbara Schäfer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conventional Kinesin Holoenzymes Are Composed of Heavy and Light Chain Homodimers†

(2008) Scott R. DeBoer et al.   BIOCHEMISTRY

Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia

(2008) Moneef Shoukier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Na+channels get anchored…with a little help: Figure 1.

(2008) Matthew N. Rasband   JOURNAL OF CELL BIOLOGY

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

The emerging CK2 interactome: insights into the regulation and functions of CK2

(2008) Laszlo Gyenis et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion

(2008) James W. Connell et al.   TRAFFIC