New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing

Cinnamaldehyde in Flavored E-Cigarette Liquids Temporarily Suppresses Bronchial Epithelial Cell Ciliary Motility by Dysregulation of Mitochondrial Function

(2019) Phillip W. Clapp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Importance of in vitro conditions for modeling the in vivo dose in humans by in vitro–in vivo extrapolation (IVIVE)

(2019) Engi Abdel Hady Algharably et al.   ARCHIVES OF TOXICOLOGY

Investigation of Spatial and Temporal Variation of Particulate Matter in vitro Genotoxicity and Cytotoxicity in Relation to the Elemental Composition

(2019) Gonca Çakmak et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A New Portable In Vitro Exposure Cassette for Aerosol Sampling

(2019) Lynn E. Secondo et al.   Jove-Journal of Visualized Experiments

Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds

(2019) Elisabeth Øya et al.   International Journal of Environmental Research and Public Health

Assessing Exposure to Outdoor Air Pollution for Epidemiological Studies: Model-based and Personal Sampling Strategies

(2019) Cole Brokamp et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effects of cooking oil fumes-derived PM2.5 on blood vessel formation through ROS-mediated NLRP3 inflammasome pathway in human umbilical vein endothelial cells

(2019) Chaowei Shen et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Baseline Toxicity and Volatility Cutoff in Reporter Gene Assays Used for High-Throughput Screening

(2019) Beate I. Escher et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium

(2019) Adam M. Speen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

(2019) John F Wambaugh et al.   TOXICOLOGICAL SCIENCES

Comparative mechanisms of PAH toxicity by benzo[a]pyrene and dibenzo[def,p]chrysene in primary human bronchial epithelial cells cultured at air-liquid interface

(2019) Yvonne Chang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment

(2019) Rebecca C. Fry et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of multidrug resistance-associated protein 3 expression by diesel exhaust particle extract in human bronchial epithelial BEAS-2B cells

(2019) Marc Le Vée et al.   TOXICOLOGY IN VITRO

Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

(2019) Zhongyu Liu et al.   Biomedical Optics Express

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

(2019) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Biological Effects of Complete Gasoline Engine Emissions Exposure in a 3D Human Airway Model (MucilAirTM) and in Human Bronchial Epithelial Cells (BEAS-2B)

(2019) Pavel Rossner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In Vitro Aerosol Exposure to Nanomaterials: From Laboratory to Environmental Field Toxicity Testing

(2019) Trevor B. Tilly et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: Amelioration by fisetin

(2019) Hina Agraval et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Donora Smog Revisited: 70 Years After the Event That Inspired the Clean Air Act

(2018) Elizabeth T. Jacobs et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Accelerating the Pace of Chemical Risk Assessment

(2018) Robert J. Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators

(2018) Ingrid Elisia et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Age-associated Changes in the Respiratory Epithelial Response to Influenza Infection

(2018) Kelly D Chason et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics

(2018) John F Wambaugh et al.   TOXICOLOGICAL SCIENCES

Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity

(2018) Swapna Upadhyay et al.   TOXICOLOGICAL SCIENCES

Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity

(2018) Amy J. Clippinger et al.   TOXICOLOGY IN VITRO

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

(2018) Pieter S. Hiemstra et al.   TOXICOLOGY IN VITRO

In vitro to in vivo extrapolation for high throughput prioritization and decision making

(2018) Shannon M. Bell et al.   TOXICOLOGY IN VITRO

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

(2018) Travis B. Nielsen et al.   Jove-Journal of Visualized Experiments

In vitro cellular toxicity induced by extractable organic fractions of particles exhausted from urban combustion sources - Role of PAHs

(2018) Ekaterini Velali et al.   ENVIRONMENTAL POLLUTION

A new cell culture exposure system for studying the toxicity of volatile chemicals at the air–liquid interface

(2018) Jose Zavala et al.   INHALATION TOXICOLOGY

A review of inflammatory mechanism in airway diseases

(2018) Parya Aghasafari et al.   INFLAMMATION RESEARCH

Particulate Matter Air Pollution: Effects on the Cardiovascular System

(2018) Robert B. Hamanaka et al.   Frontiers in Endocrinology

Air pollution, cardiovascular endpoints and susceptibility by stress and material resources: a systematic review of the evidence

(2017) Christina H. Fuller et al.   Environmental Health

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

(2017) Nisha S. Sipes et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Temporal structure/function variation in cultured differentiated human nasal epithelium associated with acute single exposure to tobacco smoke or E-cigarette vapor

(2017) Johnny L. Carson et al.   INHALATION TOXICOLOGY

Framework for assessing causality of air pollution-related health effects for reviews of the National Ambient Air Quality Standards

(2017) Elizabeth Oesterling Owens et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Transcriptomic analyses of human bronchial epithelial cells BEAS-2B exposed to atmospheric fine particulate matter PM 2.5

(2017) Yang Li et al.   TOXICOLOGY IN VITRO

Regulating temperature and relative humidity in air–liquid interface in vitro systems eliminates cytotoxicity resulting from control air exposures

(2017) Jose Zavala et al.   Toxicology Research

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methodological considerations when conducting in vitro, air–liquid interface exposures to engineered nanoparticle aerosols

(2016) Lynn E. Secondo et al.   CRITICAL REVIEWS IN TOXICOLOGY

Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution

(2016) Jose Zavala et al.   INHALATION TOXICOLOGY

Analysis of the Effects of Cell Stress and Cytotoxicity onIn VitroAssay Activity Across a Diverse Chemical and Assay Space

(2016) Richard Judson et al.   TOXICOLOGICAL SCIENCES

In vitro assays as a tool for determination of VOCs toxic effect on respiratory system: A critical review

(2016) Grażyna Gałęzowska et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

(2015) Martyn T. Smith et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Ambient Air Pollution Exposure Estimation for the Global Burden of Disease 2013

(2015) Michael Brauer et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects on health of air pollution: a narrative review

(2015) Pier Mannuccio Mannucci et al.   Internal and Emergency Medicine

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Quantitative in vitro-to-in vivo extrapolation in a high-throughput environment

(2015) Barbara A. Wetmore   TOXICOLOGY

The Gillings Sampler – An electrostatic air sampler as an alternative method for aerosol in vitro exposure studies

(2014) Jose Zavala et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment

(2014) James M. Armitage et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The relevance and potential roles of microphysiological systems in biology and medicine

(2014) John P Wikswo   EXPERIMENTAL BIOLOGY AND MEDICINE

Nano Aerosol Chamber forIn-VitroToxicity (NACIVT) studies

(2014) Natalie Jeannet et al.   Nanotoxicology

Toxicity of Nanoparticles Embedded in Paints Compared with Pristine Nanoparticles in Mice

(2014) Stijn Smulders et al.   TOXICOLOGICAL SCIENCES

DNA methylation in nasal epithelial cells from smokers: identification of ULBP3-related effects

(2013) Julia E. Rager et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Formaldehyde and Epigenetic Alterations: MicroRNA Changes in the Nasal Epithelium of Nonhuman Primates

(2013) Julia E. Rager et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Basic concepts of epigenetics

(2013) Michal Inbar-Feigenberg et al.   FERTILITY AND STERILITY

Quantifying the health impacts of air pollution under a changing climate—a review of approaches and methodology

(2013) Sarunya Sujaritpong et al.   INTERNATIONAL JOURNAL OF BIOMETEOROLOGY

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate

(2013) John F. Wambaugh et al.   TOXICOLOGICAL SCIENCES

Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays

(2013) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds

(2013) Miyoung Yoon et al.   TOXICOLOGY IN VITRO

Culturing of Human Nasal Epithelial Cells at the Air Liquid Interface

(2013) Loretta Müller et al.   Jove-Journal of Visualized Experiments

Interference of engineered nanoparticles with in vitro toxicity assays

(2012) Alexandra Kroll et al.   ARCHIVES OF TOXICOLOGY

Particle-Induced Artifacts in the MTT and LDH Viability Assays

(2012) Amara L. Holder et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cellular Uptake and Toxic Effects of Fine and Ultrafine Metal-Sulfate Particles in Human A549 Lung Epithelial Cells

(2012) Mathias Könczöl et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantitativein vitrotoin vivoextrapolation of cell-based toxicity assay results

(2012) Miyoung Yoon et al.   CRITICAL REVIEWS IN TOXICOLOGY

In Vitro Exposures in Diesel Exhaust Atmospheres: Resuspension of PM from Filters versus Direct Deposition of PM from Air

(2012) Kim M. Lichtveld et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner

(2012) Jessica L. Bolton et al.   FASEB JOURNAL

Effects of nanoparticle-rich diesel exhaust particles on IL-17 productionin vitro

(2012) Ryosuke Nakamura et al.   Journal of Immunotoxicology

Toxicological properties of emission particles from heavy duty engines powered by conventional and bio-based diesel fuels and compressed natural gas

(2012) Pasi I Jalava et al.   Particle and Fibre Toxicology

Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation

(2012) Ting Wang et al.   Particle and Fibre Toxicology

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Controlled human exposures to diesel exhaust

(2012) A Ghio et al.   SWISS MEDICAL WEEKLY

Formaldehyde Carcinogenicity Research

(2012) James A. Swenberg et al.   TOXICOLOGIC PATHOLOGY

The effect of a novel tobacco process on the in vitro cytotoxicity and genotoxicity of cigarette smoke particulate matter

(2012) R. Combes et al.   TOXICOLOGY IN VITRO

Toxicological analysis of limonene reaction products using an in vitro exposure system

(2012) Stacey E. Anderson et al.   TOXICOLOGY IN VITRO

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

(2012) Sandra Coecke et al.   TOXICOLOGY IN VITRO

Analytical in vitro approach for studying cyto- and genotoxic effects of particulate airborne material

(2011) Michaela Aufderheide et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cytokine Expression Profile in Human Lungs Undergoing Normothermic Ex-Vivo Lung Perfusion

(2011) Miral R. Sadaria et al.   ANNALS OF THORACIC SURGERY

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

A Toxicogenomic Comparison of Primary and Photochemically Altered Air Pollutant Mixtures

(2011) Julia E. Rager et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung—A dialog between aerosol science and biology

(2011) Hanns-Rudolf Paur et al.   JOURNAL OF AEROSOL SCIENCE

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Do Airway Epithelium Air–Liquid Cultures Represent theIn VivoAirway Epithelium Transcriptome?

(2010) Anna Dvorak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epigenetic Changes Induced by Air Toxics: Formaldehyde Exposure Alters miRNA Expression Profiles in Human Lung Cells

(2010) Julia E. Rager et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Air Pollution Toxicology--A Brief Review of the Role of the Science in Shaping the Current Understanding of Air Pollution Health Risks

(2010) L. W. Stanek et al.   TOXICOLOGICAL SCIENCES

Human primary bronchial lung cell constructs: The new respiratory models

(2010) Kelly BéruBé et al.   TOXICOLOGY

Reduced Expression of IRF7 in Nasal Epithelial Cells from Smokers after Infection with Influenza

(2009) Ilona Jaspers et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Direct Particle-to-Cell Deposition of Coarse Ambient Particulate Matter Increases the Production of Inflammatory Mediators from Cultured Human Airway Epithelial Cells

(2009) John Volckens et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line

(2009) Pasi I. Jalava et al.   INHALATION TOXICOLOGY

A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles

(2009) Anke Lenz et al.   Particle and Fibre Toxicology

Air pollution and mortality: A history

(2008) H.R. Anderson   ATMOSPHERIC ENVIRONMENT

HOW TO DEAL WITH LIPOPHILIC AND VOLATILE ORGANIC SUBSTANCES IN MICROTITER PLATE ASSAYS

(2008) René Schreiber et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Alternative test methods in inhalation toxicology: Challenges and opportunities

(2008) Daniel L. Costa   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments

(2008) Josje H.E. Arts et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

In vitromodels of the human epithelial airway barrier to study the toxic potential of particulate matter

(2008) Barbara Rothen-Rutishauser et al.   Expert Opinion on Drug Metabolism & Toxicology

Design and Testing of Electrostatic AerosolIn VitroExposure System (EAVES): An Alternative Exposure System for Particles

(2008) K. de Bruijne et al.   INHALATION TOXICOLOGY

Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms

(2008) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Respiratory Toxicity of Diacetyl in C57Bl/6 Mice

(2008) Daniel L. Morgan et al.   TOXICOLOGICAL SCIENCES

Vulnerability to air pollution health effects

(2007) Anna Makri et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

An in vitro approach to assess the toxicity of inhaled tobacco smoke components: Nicotine, cadmium, formaldehyde and urethane

(2007) Dominique Balharry et al.   TOXICOLOGY

Differential binding of cytokines to environmentally relevant particles: A possible source for misinterpretation of in vitro results?

(2007) A. Kocbach et al.   TOXICOLOGY LETTERS