Importance of in vitro conditions for modeling the in vivo dose in humans by in vitro–in vivo extrapolation (IVIVE)

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms

(2018) Chris S. Pridgeon et al.   ARCHIVES OF TOXICOLOGY

Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP)

(2018) Gheorghe-Andrei Dan et al.   EUROPACE

The importance of protein binding for the in vitro–in vivo extrapolation (IVIVE)—example of ibuprofen, a highly protein-bound substance

(2016) H. Mielke et al.   ARCHIVES OF TOXICOLOGY

Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data

(2016) Jochem Louisse et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Food for thought … on alternative methods for chemical safety testing

(2016) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

A Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data

(2015) Jing-Tao Lu et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

In vitro kinetics of amiodarone and its major metabolite in two human liver cell models after acute and repeated treatments

(2015) Giuliana Pomponio et al.   TOXICOLOGY IN VITRO

Quantitative in vitro to in vivo extrapolation of tissues toxicity

(2015) Jérémy Hamon et al.   TOXICOLOGY IN VITRO

Biokinetics in repeated-dosing in vitro drug toxicity studies

(2015) Nynke I. Kramer et al.   TOXICOLOGY IN VITRO

Consensus report on the future of animal-free systemic toxicity testing

(2014) Marcel Leist   ALTEX-Alternatives to Animal Experimentation

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment

(2013) Jos G. Bessems et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

(2012) Sandra Coecke et al.   TOXICOLOGY IN VITRO

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

(2011) Sarah Adler et al.   ARCHIVES OF TOXICOLOGY