Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
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Title
Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
Authors
Keywords
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Journal
Genome Medicine
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-03-30
DOI
10.1186/s13073-020-00731-8
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Note: Only part of the references are listed.- Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial
- (2019) Brian I Rini et al. LANCET
- Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
- (2019) Markus W. Löffler et al. Genome Medicine
- Adjuvant therapy in renal cell carcinoma
- (2019) Anita Gul et al. CANCER
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment
- (2019) Alice Newey et al. Journal for ImmunoTherapy of Cancer
- Identification of a selective inhibitor of human monocarboxylate transporter 4
- (2018) Yuya Futagi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Clinical utility of the S3-score for molecular prediction of outcome in non-metastatic and metastatic clear cell renal cell carcinoma
- (2018) Florian Büttner et al. BMC Medicine
- Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
- (2018) Samra Turajlic et al. CELL
- Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
- (2018) Thomas J. Mitchell et al. CELL
- Mapping the tumour human leukocyte antigen (HLA) ligandome by mass spectrometry
- (2018) Lena Katharina Freudenmann et al. IMMUNOLOGY
- Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)
- (2018) Nicolas Babault et al. JOURNAL OF MEDICINAL CHEMISTRY
- A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
- (2018) Aimo Kannt et al. Scientific Reports
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
- (2018) Matthew D. Young et al. SCIENCE
- Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
- (2018) Daniel Ackerman et al. Cell Reports
- Trial watch: peptide-based vaccines in anticancer therapy
- (2018) Lucillia Bezu et al. OncoImmunology
- The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy
- (2018) Tatjana Bilich et al. BLOOD
- Evolving Systemic Treatment Landscape for Patients With Advanced Renal Cell Carcinoma
- (2018) Rana R. McKay et al. JOURNAL OF CLINICAL ONCOLOGY
- Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions
- (2018) W. Kimryn Rathmell et al. JOURNAL OF CLINICAL ONCOLOGY
- Actively personalized vaccination trial for newly diagnosed glioblastoma
- (2018) Norbert Hilf et al. NATURE
- Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
- (2018) Derin B. Keskin et al. NATURE
- PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools
- (2018) Huaiyu Mi et al. NUCLEIC ACIDS RESEARCH
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- Comprehensive Metabolomic and Lipidomic Profiling of Human Kidney Tissue: A Platform Comparison
- (2017) Patrick Leuthold et al. JOURNAL OF PROTEOME RESEARCH
- An immunogenic personal neoantigen vaccine for patients with melanoma
- (2017) Patrick A. Ott et al. NATURE
- Neoantigen prediction and the need for validation
- (2017) Antonella Vitiello et al. NATURE BIOTECHNOLOGY
- DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats
- (2017) David Brocks et al. NATURE GENETICS
- Systemic Therapy for Metastatic Renal-Cell Carcinoma
- (2017) Toni K. Choueiri et al. NEW ENGLAND JOURNAL OF MEDICINE
- The immunopeptidomic landscape of ovarian carcinomas
- (2017) Heiko Schuster et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein
- (2017) Yong Lei et al. Nature Communications
- Cell-Type-Specific Gene Programs of the Normal Human Nephron Define Kidney Cancer Subtypes
- (2017) David Lindgren et al. Cell Reports
- An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
- (2016) A. Ari Hakimi et al. CANCER CELL
- Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma
- (2016) D. J. Kwiatkowski et al. CLINICAL CANCER RESEARCH
- Mass spectrometry-based antigen discovery for cancer immunotherapy
- (2016) Michal Bassani-Sternberg et al. CURRENT OPINION IN IMMUNOLOGY
- Chemical Proteomic Profiling of Human Methyltransferases
- (2016) Benjamin D. Horning et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial
- (2016) Brian I Rini et al. LANCET ONCOLOGY
- Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy
- (2016) Bracha Shraibman et al. MOLECULAR & CELLULAR PROTEOMICS
- PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
- (2016) Natalie J. German et al. MOLECULAR CELL
- Potential regulation of glioma through the induction of apoptosis signaling via Egl-9 family hypoxia-inducible factor 3
- (2016) Ke Mao et al. Oncology Letters
- Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach
- (2016) Michelangelo Fiorentino et al. Oncotarget
- Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma
- (2016) Fengju Chen et al. Cell Reports
- Carcinogenesis of renal cell carcinoma reflected in HLA ligands: A novel approach for synergistic peptide vaccination design
- (2016) Martin G. Klatt et al. OncoImmunology
- Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes
- (2016) Stefan Winter et al. Scientific Reports
- The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell-based immunotherapy
- (2015) S. Walz et al. BLOOD
- Validation and genomic interrogation of theMETvariant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma
- (2015) A. Ari Hakimi et al. CANCER
- A combined approach of human leukocyte antigen ligandomics and immunogenicity analysis to improve peptide-based cancer immunotherapy
- (2015) Janet Kerstin Peper et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer
- (2015) N. A. Giraldo et al. CLINICAL CANCER RESEARCH
- Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron
- (2015) Florian Büttner et al. EUROPEAN UROLOGY
- Antigen-specific T cell therapies for cancer: Figure 1.
- (2015) Teresa Manzo et al. HUMAN MOLECULAR GENETICS
- Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
- (2015) Heidi Högel et al. Molecular Cancer
- Spatial reconstruction of single-cell gene expression data
- (2015) Rahul Satija et al. NATURE BIOTECHNOLOGY
- Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Toni K. Choueiri et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- MetaboAnalyst 3.0—making metabolomics more meaningful
- (2015) Jianguo Xia et al. NUCLEIC ACIDS RESEARCH
- Immunoinformatics and epitope prediction in the age of genomic medicine
- (2015) Linus Backert et al. Genome Medicine
- Immune signature of tumor infiltrating immune cells in renal cancer
- (2015) Katharina Geissler et al. OncoImmunology
- Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma
- (2014) Robert J. Motzer et al. JOURNAL OF CLINICAL ONCOLOGY
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- (2014) Marco Gerlinger et al. NATURE GENETICS
- Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma
- (2014) Francesco Gatto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL)
- (2014) Daniel J. Kowalewski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GSVA: gene set variation analysis for microarray and RNA-Seq data
- (2013) Sonja Hänzelmann et al. BMC BIOINFORMATICS
- DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome
- (2013) P. Fisel et al. CLINICAL CANCER RESEARCH
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines
- (2013) N. Hacohen et al. Cancer Immunology Research
- Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia
- (2012) J. Greiner et al. BLOOD
- Next-generation peptide vaccines for advanced cancer
- (2012) Akira Yamada et al. CANCER SCIENCE
- Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients
- (2012) A. Cai et al. CLINICAL CANCER RESEARCH
- Epigenetic reprogramming of cancer cells via targeted DNA methylation
- (2012) Ashley G. Rivenbark et al. Epigenetics
- PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response
- (2012) Liang Xie et al. JOURNAL OF CLINICAL INVESTIGATION
- Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival
- (2012) Steffen Walter et al. NATURE MEDICINE
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase
- (2011) Nan Chen et al. CELL RESEARCH
- Prolyl Hydroxylase PHD3 Enhances the Hypoxic Survival and G1 to S Transition of Carcinoma Cells
- (2011) Heidi Högel et al. PLoS One
- Therapeutic cancer vaccines: are we there yet?
- (2010) Christopher A. Klebanoff et al. IMMUNOLOGICAL REVIEWS
- Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma
- (2010) John H. Sampson et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival
- (2010) Bernard Escudier et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase III Trial of Bevacizumab Plus Interferon Alfa Versus Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: Final Results of CALGB 90206
- (2010) Brian I. Rini et al. JOURNAL OF CLINICAL ONCOLOGY
- HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression
- (2010) Daniel A. Tennant et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The DNA demethylating agent 5-aza-2′-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
- (2010) Maika Almstedt et al. LEUKEMIA RESEARCH
- Epigenetics of renal cell carcinoma: the path towards new diagnostics and therapeutics
- (2010) Mark R Morris et al. Genome Medicine
- HLA ligand profiles of primary renal cell carcinoma maintained in metastases
- (2009) Juliane Sarah Stickel et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Resistance to targeted therapy in renal-cell carcinoma
- (2009) Brian I Rini et al. LANCET ONCOLOGY
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Epigenetic Enhancement of Antigen Processing and Presentation Promotes Immune Recognition of Tumors
- (2008) A. F. Setiadi et al. CANCER RESEARCH
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
- (2008) Da Wei Huang et al. NUCLEIC ACIDS RESEARCH
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