Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas

(2016) G. G. Malouf et al.   CLINICAL CANCER RESEARCH

DNA Methylation of ADME Genes

(2016) P Fisel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Epigenetic Modulators and the New Immunotherapies

(2016) Anthony E. Dear   NEW ENGLAND JOURNAL OF MEDICINE

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts

(2015) J. W. Cassidy et al.   CANCER RESEARCH

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

(2015) A. G. Schuller et al.   CLINICAL CANCER RESEARCH

CYP3A5 and ABCB1 Polymorphisms as Predictors for Sunitinib Outcome in Metastatic Renal Cell Carcinoma

(2015) Meta H.M. Diekstra et al.   EUROPEAN UROLOGY

Survival Prediction of Clear Cell Renal Cell Carcinoma Based on Gene Expression Similarity to the Proximal Tubule of the Nephron

(2015) Florian Büttner et al.   EUROPEAN UROLOGY

Understanding Pathologic Variants of Renal Cell Carcinoma: Distilling Therapeutic Opportunities from Biologic Complexity

(2015) Brian Shuch et al.   EUROPEAN UROLOGY

A 16-gene assay to predict recurrence after surgery in localised renal cell carcinoma: development and validation studies

(2015) Brian Rini et al.   LANCET ONCOLOGY

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

(2015) Jin-Huan Wei et al.   Nature Communications

Epigenetic synergy between decitabine and platinum derivatives

(2015) Taichun Qin et al.   Clinical Epigenetics

Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

(2015) Wataru Habano et al.   Clinical Epigenetics

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib

(2014) Benoit Beuselinck et al.   ACTA ONCOLOGICA

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

A Comprehensive DNA Methylation Profile of Epithelial-to-Mesenchymal Transition

(2014) F. J. Carmona et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research

(2014) Pascale Fisel et al.   Expert Opinion on Drug Metabolism & Toxicology

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Cancer: Staying together on the road to metastasis

(2014) Alessia Bottos et al.   NATURE

Epigenomic Alterations in Breast Carcinoma from Primary Tumor to Locoregional Recurrences

(2014) Matahi Moarii et al.   PLoS One

Discrepant NOXA (PMAIP1) transcript and NOXA protein levels: a potential Achilles’ heel in mantle cell lymphoma

(2014) M A Dengler et al.   Cell Death & Disease

DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome

(2013) P. Fisel et al.   CLINICAL CANCER RESEARCH

Transporters in Drug Development and Clinical Pharmacology

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

International Transporter Consortium Commentary on Clinically Important Transporter Polymorphisms

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis

(2013) Diego M. Marzese et al.   HUMAN MOLECULAR GENETICS

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases

(2013) M. J. Aryee et al.   Science Translational Medicine

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

(2013) Christopher J Ricketts et al.   Clinical Epigenetics

Renal Transporters in Drug Development

(2012) Kari M. Morrissey et al.   Annual Review of Pharmacology and Toxicology

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer

(2012) Sakari Vanharanta et al.   NATURE MEDICINE

A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

(2012) S. Sivanand et al.   Science Translational Medicine

Basic Research in Kidney Cancer

(2011) Egbert Oosterwijk et al.   EUROPEAN UROLOGY

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Pharmacogenetic Pathway Analysis for Determination of Sunitinib-Induced Toxicity

(2009) Nielka P. van Erp et al.   JOURNAL OF CLINICAL ONCOLOGY

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols