Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

RPA and RAD51: fork reversal, fork protection, and genome stability

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RPA and RAD51: fork reversal, fork protection, and genome stability

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The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

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Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

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SMARCAL1 Resolves Replication Stress at ALT Telomeres

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Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

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Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

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Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

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SMARCAL1 maintains telomere integrity during DNA replication

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Molecular mechanisms of activity and derepression of alternative lengthening of telomeres

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Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

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Holliday junction processing enzymes as guardians of genome stability

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Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

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5′ C-rich telomeric overhangs are an outcome of rapid telomere truncation events

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ATR phosphorylates SMARCAL1 to prevent replication fork collapse

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Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

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Rescuing Stalled or Damaged Replication Forks

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Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST

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Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening

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Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

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(2012) Jeremy Schwartzentruber et al.   NATURE

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Cancer and Telomeres--An ALTernative to Telomerase

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Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

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Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

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Mammalian 5′ C-Rich Telomeric Overhangs Are a Mark of Recombination-Dependent Telomere Maintenance

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Altered Telomeres in Tumors with ATRX and DAXX Mutations

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TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

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A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast

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Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

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Alternative lengthening of telomeres: models, mechanisms and implications

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Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

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Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

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DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY

Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

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Unusual Telomeric DNAs in Human Telomerase-Negative Immortalized Cells

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