Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
出版年份 2020 全文链接
标题
Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
作者
关键词
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出版物
Scientific Reports
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-05-08
DOI
10.1038/s41598-020-64902-8
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hepatic Monoacylglycerol Acyltransferase 1 is Induced by Prolonged Food Deprivation to Modulate the Hepatic Fasting Response
- (2019) Andrew J. Lutkewitte et al. JOURNAL OF LIPID RESEARCH
- Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease
- (2019) Adel Hammoutene et al. JOURNAL OF HEPATOLOGY
- The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential
- (2019) Jean-Charles Fruchart et al. Cardiovascular Diabetology
- Chemokine ligand 20 (CCL20) expression increases with NAFLD stage and hepatic stellate cell activation and is regulated by miR-590-5p
- (2019) Amanda Hanson et al. CYTOKINE
- Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate
- (2019) Yusuke Sasaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Adaptive immunity: an emerging player in the progression of NAFLD
- (2019) Salvatore Sutti et al. Nature Reviews Gastroenterology & Hepatology
- CIDE family proteins control lipid homeostasis and the development of metabolic diseases
- (2019) Feng‐Jung Chen et al. TRAFFIC
- Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in MacrophagesHighlights
- (2018) Tadayoshi Karasawa et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
- (2018) David Højland Ipsen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis
- (2018) Kia M. Peters et al. CURRENT OPINION IN LIPIDOLOGY
- Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial
- (2018) Shun Ishibashi et al. Journal of Clinical Lipidology
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
- (2018) Byeong-Moo Kim et al. Scientific Reports
- The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
- (2018) Konstantin Kazankov et al. Nature Reviews Gastroenterology & Hepatology
- Dynamics and functions of lipid droplets
- (2018) James A. Olzmann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance
- (2017) Geoffrey A. Preidis et al. JOURNAL OF CLINICAL INVESTIGATION
- Liver sinusoidal endothelial cells: Physiology and role in liver diseases
- (2017) Johanne Poisson et al. JOURNAL OF HEPATOLOGY
- Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol
- (2017) Janin Henkel et al. MOLECULAR MEDICINE
- Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
- (2017) Zobair Younossi et al. Nature Reviews Gastroenterology & Hepatology
- Lipid droplets and liver disease: from basic biology to clinical implications
- (2017) Nina L. Gluchowski et al. Nature Reviews Gastroenterology & Hepatology
- Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance
- (2017) Yasutaka Miyachi et al. Cell Reports
- Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis
- (2017) Yasushi Honda et al. Scientific Reports
- GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells
- (2017) Quan Li et al. Scientific Reports
- The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis
- (2016) Nathalie Hennuyer et al. ATHEROSCLEROSIS
- Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition
- (2016) Weihua Liu et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
- (2016) Alexandra Montagner et al. GUT
- Molecular Pathogenesis of NASH
- (2016) Alessandra Caligiuri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
- (2016) Elena Buzzetti et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Mechanisms of intrahepatic triglyceride accumulation
- (2016) Claudia Ress WORLD JOURNAL OF GASTROENTEROLOGY
- Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease
- (2016) Hirotaka Shoji et al. Scientific Reports
- Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
- (2015) Samar H. Ibrahim et al. HEPATOLOGY
- Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver
- (2015) Sana Raza-Iqbal et al. Journal of Atherosclerosis and Thrombosis
- PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis
- (2015) Sven Francque et al. JOURNAL OF HEPATOLOGY
- Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression
- (2015) Dan Zhou et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression
- (2015) Masashi Miyao et al. LABORATORY INVESTIGATION
- The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
- (2015) Chiara Saponaro et al. Nutrients
- Lipid droplet biogenesis
- (2014) Florian Wilfling et al. CURRENT OPINION IN CELL BIOLOGY
- PPARβ/δ activation of CD300a controls intestinal immunity
- (2014) Toshiya Tanaka et al. Scientific Reports
- Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
- (2013) Jennifer E. Lambert et al. GASTROENTEROLOGY
- Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)
- (2013) Akinobu Takaki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
- (2013) Masato Fujii et al. Medical Molecular Morphology
- Murine Diacylglycerol Acyltransferase-2 (DGAT2) Can Catalyze Triacylglycerol Synthesis and Promote Lipid Droplet Formation Independent of Its Localization to the Endoplasmic Reticulum
- (2011) Pamela J. McFie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes
- (2008) Hideaki Miyoshi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans
- (2008) Satish C. Kalhan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
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