Mechanisms of intrahepatic triglyceride accumulation

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Hepatic lipid droplet biology: Getting to the root of fatty liver

(2015) Douglas G. Mashek et al.   HEPATOLOGY

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Perilipin 5: From fatty liver to hepatic lipodystrophy?

(2015) Julia Szendroedi et al.   HEPATOLOGY

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

Hepatitis C viral proteins perturb metabolic liver zonation

(2015) Marie Moreau et al.   JOURNAL OF HEPATOLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

(2015) Wei Zhong et al.   JOURNAL OF HEPATOLOGY

Dietary models of insulin resistance

(2015) James Deer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatitis C virus and lipid droplets: finding a niche

(2015) Ana Filipe et al.   TRENDS IN MOLECULAR MEDICINE

Advances in understanding and treating liver diseases during pregnancy: A review

(2015) Kenya Kamimura   WORLD JOURNAL OF GASTROENTEROLOGY

Acute fatty liver of pregnancy: Over six months follow-up study of twenty-five patients

(2015) Hao-Feng Xiong   WORLD JOURNAL OF GASTROENTEROLOGY

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

(2015) Kristine Griffett et al.   Molecular Metabolism

Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated ReceptorαProtects Against Alcoholic Liver Disease

(2014) Heng-Hong Li et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis

(2014) Fen Xu et al.   DIABETES

Role of Mitochondria in Nonalcoholic Fatty Liver Disease

(2014) Fatiha Nassir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Potential Treatment of Nonalcoholic Fatty Liver Disease with SIRT1 Activators

(2014)   Journal of Gastrointestinal and Liver Diseases

Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion

(2014) Jolene S.Y. Tan et al.   Journal of Genetics and Genomics

Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis C

(2014) H. Leleu et al.   JOURNAL OF VIRAL HEPATITIS

Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1 /Liver-Specific PGC-1  Upregulation

(2014) W. Yao et al.   JOURNAL OF VIROLOGY

Forkhead Box Transcription Factor Regulation and Lipid Accumulation by Hepatitis C Virus

(2014) S. K. Bose et al.   JOURNAL OF VIROLOGY

Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice

(2014) Rotonya M. Carr et al.   PLoS One

Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

(2014) W. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-Induced Hepatic Steatosis

(2014) Naga Chalasani et al.   SEMINARS IN LIVER DISEASE

Alcoholic disease: Liver and beyond

(2014) Alba Rocco   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome

(2013) Fahed Parvaiz et al.   ARCHIVES OF VIROLOGY

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

(2013) Huquan Yin et al.   GASTROENTEROLOGY

Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism for hepatic steatosis

(2013) Ragunath Singaravelu et al.   HEPATOLOGY

1319 SIMTUZUMAB, AN ANTIFIBROTIC MONOCLONAL ANTIBODY AGAINST LYSYL OXIDASE-LIKE 2 (LOXL2) ENZYME, APPEARS SAFE AND WELL TOLERATED IN PATIENTS WITH LIVER DISEASE OF DIVERSE ETIOLOGY

(2013) A.H. Talal et al.   JOURNAL OF HEPATOLOGY

Drug-induced liver injury in obesity

(2013) Bernard Fromenty   JOURNAL OF HEPATOLOGY

Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction ofPGC1αand dephosphorylation of FoxO1

(2013) C. Bernsmeier et al.   JOURNAL OF VIRAL HEPATITIS

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly

(2013) Qisheng Li et al.   NATURE MEDICINE

Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice

(2012) Rotonya M. Carr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Apolipoprotein A5 internalized by human adipocytes modulates cellular triglyceride content

(2012) Xiao-Yan Zheng et al.   BIOLOGICAL CHEMISTRY

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly

(2012) C. Flannery et al.   DIABETES

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

(2012) Jihong Lian et al.   HEPATOLOGY

Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans

(2012) Jennifer E. Lambert et al.   HEPATOLOGY

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation

(2012) Xuanhe Li et al.   JOURNAL OF LIPID RESEARCH

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

(2012) K. F. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling

(2011) Rosalind A. Coleman et al.   CHEMICAL REVIEWS

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

(2011) C. Lipina et al.   DIABETOLOGIA

The role of apolipoprotein A5 in non-alcoholic fatty liver disease

(2011) C. Ress et al.   GUT

Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice

(2011) Ming Hu et al.   HEPATOLOGY

Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

(2011) Zhanguo Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances

(2011) Devanshi Seth et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis C

(2010) Elena Lima-Cabello et al.   CLINICAL SCIENCE

The impact of liver fat vs visceral fat in determining categories of prediabetes

(2010) K. Kantartzis et al.   DIABETOLOGIA

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease

(2010) S. Kaser et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Hepatitis C Virus Differentially Modulates Activation of Forkhead Transcription Factors and Insulin-Induced Metabolic Gene Expression

(2010) A. Banerjee et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN–Beta Induction

(2010) Hiroyuki Oshiumi et al.   PLoS One

SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells

(2009) Marcello Persico et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Liver injury in acute fatty liver of pregnancy: Possible link to placental mitochondrial dysfunction and oxidative stress

(2009) Sathish Kumar Natarajan et al.   HEPATOLOGY

Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up

(2009) Kathleen E. Corey et al.   HEPATOLOGY

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C

(2009) Pierre-Yves Bochud et al.   JOURNAL OF HEPATOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women

(2009) Bettina Mittendorfer et al.   Obesity

Lipoprotein Lipase Expression in Livers of Morbidly Obese Patients Could be Responsible for Liver Steatosis

(2009) Eva Pardina et al.   OBESITY SURGERY

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation

(2008) Suthat Liangpunsakul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A prospective national study of acute fatty liver of pregnancy in the UK

(2008) M Knight et al.   GUT

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease

(2008) Nobito Higuchi et al.   HEPATOLOGY RESEARCH

Silencing of Hepatic Fatty Acid Transporter Protein 5in VivoReverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

(2008) Holger Doege et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyceroneogenesis Is the Dominant Pathway for Triglyceride Glycerol Synthesisin Vivoin the Rat

(2008) Colleen K. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARα activation is essential for HCV core protein–induced hepatic steatosis and hepatocellular carcinoma in mice

(2008) Naoki Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-alcoholic fatty liver disease: The mist gradually clears

(2008) Nimantha Mark Wilfred de Alwis et al.   JOURNAL OF HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Insulin resistance, inflammation, and non-alcoholic fatty liver disease

(2008) Herbert Tilg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM