CIDE family proteins control lipid homeostasis and the development of metabolic diseases

CIDE Proteins in Human Health and Disease

(2019) Mark Slayton et al.   Cells

Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites

(2019) Lu Su et al.   EMBO JOURNAL

The biogenesis of lipid droplets: Lipids take center stage

(2019) Mingming Gao et al.   PROGRESS IN LIPID RESEARCH

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

LRRK2 mediated Rab8a phosphorylation promotes lipid storage

(2018) Miao Yu et al.   Lipids in Health and Disease

Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy

(2018) Xiaoshuai Huang et al.   NATURE BIOTECHNOLOGY

SREBP1c mediates the effect of acetaldehyde on Cidea expression in Alcoholic fatty liver Mice

(2018) Qi He et al.   Scientific Reports

Polybasic RKKR motif in the linker region of lipid droplet (LD)–associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids

(2018) Jia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes

(2017) Yuki Nishimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC6-mediated acetylation of lipid droplet–binding protein CIDEC regulates fat-induced lipid storage

(2017) Hui Qian et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CIDE domains form functionally important higher-order assemblies for DNA fragmentation

(2017) Jae Young Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage

(2017) Simon G. Pfisterer et al.   Nature Communications

Lipid droplets and associated proteins in sebocytes

(2016) Marlon R. Schneider   EXPERIMENTAL CELL RESEARCH

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

(2016) Wenyi Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The size matters: regulation of lipid storage by lipid droplet dynamics

(2016) Jinhai Yu et al.   Science China-Life Sciences

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

(2015) Ming-Jiang Xu et al.   GASTROENTEROLOGY

Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

(2015) Xu Xu et al.   HEPATOLOGY

CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis

(2015) Cédric Langhi et al.   HEPATOLOGY

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice

(2015) Linkang Zhou et al.   Nature Communications

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix

(2015) David Barneda et al.   eLife

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

(2014) Lizhen Wu et al.   DEVELOPMENTAL CELL

Cideb facilitates the lipidation of chylomicrons in the small intestine

(2014) Li-Jun Zhang et al.   JOURNAL OF LIPID RESEARCH

Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands

(2014) S. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells

(2013) Ragunath Singaravelu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes

(2013) Tan Hooi Min Grahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Open Questions in Lipid Droplet Biology

(2013) Yuki Ohsaki et al.   CHEMISTRY & BIOLOGY

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranes

(2013) S. Bouvet et al.   JOURNAL OF CELL SCIENCE

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamics and Molecular Determinants of Cytoplasmic Lipid Droplet Clustering and Dispersion

(2013) David J. Orlicky et al.   PLoS One

COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function

(2013) A. R. Thiam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes

(2013) Zhiqi Sun et al.   Nature Communications

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Cidea promotes hepatic steatosis by sensing dietary fatty acids

(2012) Linkang Zhou et al.   HEPATOLOGY

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation

(2012) Xuanhe Li et al.   JOURNAL OF LIPID RESEARCH

Postlipolytic insulin-dependent remodeling of micro lipid droplets in adipocytes

(2012) Nicholas Ariotti et al.   MOLECULAR BIOLOGY OF THE CELL

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids

(2012) Wenshan Wang et al.   NATURE MEDICINE

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential regulation of CIDEA and CIDEC expression by insulin via Akt1/2- and JNK2-dependent pathways in human adipocytes

(2011) Minoru Ito et al.   JOURNAL OF LIPID RESEARCH

Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis

(2011) Naoki Omae et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes

(2010) Rui Wang et al.   BIOCHEMICAL JOURNAL

Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb

(2010) John Zhong Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Human adenovirus 36 decreases fatty acid oxidation and increases de novo lipogenesis in primary cultured human skeletal muscle cells by promoting Cidec/FSP27 expression

(2010) Z Q Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Fat-specific Protein 27 Undergoes Ubiquitin-dependent Degradation Regulated by Triacylglycerol Synthesis and Lipid Droplet Formation

(2010) Zongqian Nian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes

(2010) Minoru Ito et al.   JOURNAL OF LIPID RESEARCH

CIDE-3 interacts with lipopolysaccharide-induced tumor necrosis factor, and overexpression increases apoptosis in hepatocellular carcinoma

(2010) Jie Min et al.   MEDICAL ONCOLOGY

Cide-a and Cide-c are induced in the progression of hepatic steatosis and inhibited by eicosapentaenoic acid

(2010) Yasutaka Jinno et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Functional analysis of FSP27 protein regions for lipid droplet localization, caspase-dependent apoptosis, and dimerization with CIDEA

(2009) Kun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

(2009) Junjie Hu et al.   CELL

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B

(2009) Jing Ye et al.   Cell Metabolism

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation inCIDEC

(2009) Oscar Rubio-Cabezas et al.   EMBO Molecular Medicine

Perilipin Controls Lipolysis by Regulating the Interactions of AB-hydrolase Containing 5 (Abhd5) and Adipose Triglyceride Lipase (Atgl)

(2009) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic and differential regulation of proteins that coat lipid droplets infatty liver dystrophicmice

(2009) Angela M. Hall et al.   JOURNAL OF LIPID RESEARCH

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets

(2009) Brittany D. M. Hodges et al.   JOURNAL OF LIPID RESEARCH

Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

(2009) Genny Orso et al.   NATURE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assessment of fat-specific protein 27 in the adipocyte lineage suggests a dual role for FSP27 in adipocyte metabolism and cell death

(2008) Ji Young Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic Steatosis in Leptin-Deficient Mice Is Promoted by the PPARγ Target Gene Fsp27

(2008) Kimihiko Matsusue et al.   Cell Metabolism

Characterization of the human CIDEA promoter in fat cells

(2008) A T Pettersson et al.   INTERNATIONAL JOURNAL OF OBESITY

Fat-specific Protein 27 Regulates Storage of Triacylglycerol

(2008) Pernille Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

A Functional Interaction between RIP140 and PGC-1  Regulates the Expression of the Lipid Droplet Protein CIDEA

(2008) M. Hallberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

Synaptic vesicle fusion

(2008) Josep Rizo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane fusion

(2008) William Wickner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice

(2008) Shen Yon Toh et al.   PLoS One

Cidea is associated with lipid droplets and insulin sensitivity in humans

(2008) V. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA