Clostridioides difficileinfection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors

(2019) Diana López-Ureña et al.   Toxins

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB

(2019) Ziyu Zhu et al.   Stem Cells International

Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B

(2018) Peng Chen et al.   SCIENCE

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B

(2018) Dennis Schöttelndreier et al.   Frontiers in Microbiology

GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells

(2018) Bahar Degirmenci et al.   NATURE

Functional defects inClostridium difficileTcdB toxin uptake identify CSPG4 receptor-binding determinants

(2017) Pulkit Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenicity Locus, Core Genome, and Accessory Gene Contributions to Clostridium difficile Virulence

(2017) Brittany B. Lewis et al.   mBio

Clinical Characteristics and Treatment Outcomes of Clostridium difficile Infections by PCR Ribotype 017 and 018 Strains

(2017) Jieun Kim et al.   PLoS One

On the acquisition and analysis of microscale thermophoresis data

(2016) Thomas H. Scheuermann et al.   ANALYTICAL BIOCHEMISTRY

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

(2016) Liang Tao et al.   NATURE

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells

(2016) Christian M. Nefzger et al.   Stem Cell Reports

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

(2016) Carrie A. Cowardin et al.   Nature Microbiology

Crystal structure of Clostridium difficile toxin A

(2016) Nicole M. Chumbler et al.   Nature Microbiology

Predominance of Clostridium difficile Ribotypes 017 and 078 among Toxigenic Clinical Isolates in Southern Taiwan

(2016) Yuan-Pin Hung et al.   PLoS One

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

(2015) K. Horvay et al.   EMBO JOURNAL

Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States

(2015) Anne F. Peery et al.   GASTROENTEROLOGY

Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England

(2015) M. D. Cairns et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Cloning and variation of ground state intestinal stem cells

(2015) Xia Wang et al.   NATURE

Identification of an epithelial cell receptor responsible forClostridium difficileTcdB-induced cytotoxicity

(2015) Michelle E. LaFrance et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

(2015) Glen P. Carter et al.   mBio

Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells

(2015) Dustin J. Flanagan et al.   Stem Cell Reports

Clostridium difficile ribotype 126 in southern Taiwan: A cluster of three symptomatic cases

(2014) Yuan-Pin Hung et al.   ANAEROBE

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

(2014) Pengfei Yuan et al.   CELL RESEARCH

Emergence of a Ribotype 244 Strain of Clostridium difficile Associated With Severe Disease and Related to the Epidemic Ribotype 027 Strain

(2014) S. K. Lim et al.   CLINICAL INFECTIOUS DISEASES

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Clostridium difficile Toxin A Attenuates Wnt/β-Catenin Signaling in Intestinal Epithelial Cells

(2014) Bruno Bezerra Lima et al.   INFECTION AND IMMUNITY

Oncogenic miRNAs and the Perils of Losing Control of a Stem Cell’s Epigenetic Identity

(2013) Piero Dalerba et al.   Cell Stem Cell

Relationship Between Bacterial Strain Type, Host Biomarkers, and Mortality in Clostridium difficile Infection

(2013) A. Sarah Walker et al.   CLINICAL INFECTIOUS DISEASES

Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

(2013) Sarah A. Kuehne et al.   JOURNAL OF INFECTIOUS DISEASES

Compartmentalized and systemic control of tissue immunity by commensals

(2013) Yasmine Belkaid et al.   NATURE IMMUNOLOGY

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Organisation in the Colonic Crypt: A Theoretical Comparison of the Pedigree and Niche Concepts

(2013) Richard C. van der Wath et al.   PLoS One

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

(2013) Weng Chuan Peng et al.   Cell Reports

Can we identify patients at high risk of recurrent Clostridium difficile infection?

(2012) C.P. Kelly   CLINICAL MICROBIOLOGY AND INFECTION

Adherens junctions as targets of microorganisms: A focus onHelicobacter pylori

(2012) Angela Margarida Costa et al.   FEBS LETTERS

Critical Roles of Notch and Wnt/β-Catenin Pathways in the Regulation of Hyperplasia and/or Colitis in Response to Bacterial Infection

(2012) Ishfaq Ahmed et al.   INFECTION AND IMMUNITY

In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system

(2012) T Jardé et al.   ONCOGENE

Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations

(2012) Richard A. Stabler et al.   PLoS One

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Toxic megacolon

(2011) Daniel M. Autenrieth et al.   INFLAMMATORY BOWEL DISEASES

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonellaregulation of intestinal stem cells through the Wnt/β-catenin pathway

(2010) Xingyin Liu et al.   FEBS LETTERS

Human Hypervirulent Clostridium difficile Strains Exhibit Increased Sporulation as Well as Robust Toxin Production

(2010) M. Merrigan et al.   JOURNAL OF BACTERIOLOGY

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Organizing the cell cortex: the role of ERM proteins

(2010) Richard G. Fehon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile

(2010) Jordi M. Lanis et al.   PLoS Pathogens

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

(2009) Carsten Schwan et al.   PLoS Pathogens

Tight junctions as targets of infectious agents

(2008) Julian A. Guttman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The intestinal stem cell

(2008) N. Barker et al.   GENES & DEVELOPMENT

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Emerging toxin A−B+ variant strain of Clostridium difficile responsible for pseudomembranous colitis at a tertiary care hospital in Korea

(2007) Bo-Moon Shin et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE